Harald Gröger

Harald Gröger (2006)

Harald Gröger (born March 21, 1968 in Franconia ) is a German chemist and biotechnologist .

Life

Harald Gröger grew up in Franconia and studied chemistry from 1988 to 1994 at the Friedrich-Alexander University Erlangen-Nuremberg and at the Carl von Ossietzky University in Oldenburg . He completed his doctoral thesis in Jürgen Martens' group, and in 1997 he was awarded a Dr. rer. nat. PhD. He then worked as a postdoctoral fellow in Masakatsu Shibasaki's laboratory at Tokyo University . In 1998 he joined SKW Trostberg AG as a research chemist and, after its merger with Degussa AG, continued to work as an industrial chemist in the Hanau-Wolfgang research center until 2006. From 2006 to 2011 he was Professor of Organic Chemistry at the University of Erlangen-Nürnberg, in 2011 he accepted an appointment at the University of Bielefeld , where he has held a chair ever since.

Act

In his graduate thesis and dissertation, as a postdoctoral researcher and an industrial chemist at SKW Trostberg AG, the scientific work was mainly of organic chemical synthesis, organocatalysis of organometallic catalysis Act. From 2001 Gröger turned mainly to enzymatic and biocatalytic processes. Gröger is one of the pioneers of chemoenzymatic synthesis in the form of one-pot processes. His scientific work covers a wide field ranging from the biocatalytic synthesis of organic and medicinal products to technical biocatalytic processes. The interdisciplinary working method between microbiology , applied genetic engineering and organic synthesis is particularly striking .

Awards

As a doctoral student, Gröger was awarded a scholarship from the Heinz Neumüller Foundation in 1996. His postdoctoral work was supported by a grant from the Japan Science and Technology Agency (JST). He received the Degussa Research Award in both the “New Products” category (2003) and the “New or Improved Processes” category (2005). In 2007 he was awarded the Thieme Journal Prize. The Society of German Chemists (GDCh) awarded Gröger the Carl Duisberg Memorial Prize in 2008 . In 2014 he was awarded the Otto Roelen Medal by DECHEMA .

Patents

Gröger is the inventor or co-inventor of almost 30 internationally registered patents, selection:

• J. Martens, W. Maison , I. Schlemminger, O. Westerhoff, H. Gröger: Precursors for PNA monomers, WO 2000002864, 2000; AU 9890645, 2000.
• H. Gröger, F. Fleischer, B. Hammer, M. Hitzler: Process for the production of N -phosphonomethyliminodiacetic acid, DE 19909200, 2000; WO 2000052014, 2002.
• H. Gröger, F. Thalhammer, F. Fleischer, B. Hammer: Process for the production of N -phosphonomethyliminodiacetic acid, DE 19914375, 2000; WO 2000059915, 2000; EP 1165572, 2002.
• H. Gröger, K.-D. Vorlop, E. Capan, Method for Producing Optically Active Cyanohydrins , WO 2001038554, 2001; DE 10058342, 2001; EP 1232277, 2003; JP 2003514567, 2003.
• M. Shibasaki , M. Kanai, G. Manickam, H. Nogami, H. Gröger, Process for the production of optically active cyanohydrins, DE 10104342, 2002.
• H. Gröger, W. Hummel, Coupled enzymatic reaction system, WO 2004009807, 2004; AU 2003257438, 2004; EP 1523552, 2005; CN 1668738, 2005; JP 2005533497, 2005; US 2006172366, 2006.
• H. Gröger, W. Hummel: Coupled enzymatic reaction system using a formate dehydrogenase from Candida boidinii , WO 2004009825, 2004; AU 2003246390, 2004; EP 1523565, 2005; CN 1668753, 2005; JP 2005533496, 2005; US 2006068458, 2006.
• S. Naamniek, W. Hummel, H. Gröger, Use of malate dehydrogenase for NADH regeneration, DE 10240603, 2004; CA 2497499, 2004; WO 2004022764, 2004; AU 2003255368, 2004; EP 1534849, 2005; JP 2005537017, 2005.
• W. Hummel, H. Gröger: Enzymatic reaction system, DE 10353548, 2004; WO 2004048561, 2004; AU 2003279389, 2004.
• C. Rollmann, H. Gröger, AB Bommarius, W. Hummel: Coupled cofactor-dependent enzymatic reaction system, WO 2004085636, 2004; DE 10313972, 2004; EP 1606400, 2005; CN 1768134, 2006; JP 2006521102, 2006; US 2006177914, 2006.
• H. Gröger, H. Hüsken, K. Drauz, K. Landfester, Enzyme Reactions in Miniemulsions , WO 2006058595, 2006; DE 102004057966, 2006.
• P. Dominguez de Maria, H. Trauthwein, O. May, H. Gröger, K. Drauz: Process for the preparation of enantiomerically enriched α-hydroxyketones, WO 2006087266, 2006; DE 102005007499, 2006.
• W. Hummel, J. Schümers, H. Gröger: Alcohol dehydrogenase from Nocardia globulera and its use, WO 2007028729, 2007; DE 102005043152, 2007.

Publications

So far, Gröger has published more than 70 scientific publications, selection:

• H. Gröger, M. Hatam, J. Martens: Synthesis of totally protected, non-proteinogenic α-amino acids and oligopeptides from 2 H -1,3-oxazines and 2 H -1,3-benzoxazines via Ugi reaction , Tetrahedron 1995, 51, 7173 -7180.
• H. Gröger, Y. Saida, H. Sasai, K. Yamaguchi, J. Martens, M. Shibasaki: A New and Highly Efficient Route to Cyclic α-Amino Phosphonates: The First Catalytic Enantioselective Hydrophosphonylation of Cyclic Imines Catalyzed by Chiral Heterobimetallic Lanthanoid Complexes, J. Am. Chem. Soc. 1998, 120, 3089-3103.
• K.-i. Yamada, SJ Harwood, H. Gröger, M. Shibasaki: The First Catalytic Asymmetric Nitro-Mannich-type Reaction Promoted by a New Heterobimetallic Complex, Angew. Chem. 1999, 111, 3713-3715; Angew. Chem. Int. Ed. 1999, 38, 3504-3506.
• H. Gröger: Enzymatic Routes to Enantiomerically Pure Aromatic α-Hydroxy Carboxylic Acids: A Further Example for the Diversity of Biocatalysis, Adv. Synth. Catal. 2001, 343, 547-558.
• H. Gröger, O. May, H. Hüsken, S. Georgeon, K. Drauz, K. Landfester: Enantioselective Enzyme Reactions in Miniemulsions as Efficient “ Nanoreactors ”, Angew. Chem. 2006, 118, 1676-1679; Angew. Chem. Int. Ed. 2006, 45, 1645-1648.
• H. Gröger, E. Burda, W. Hummel: Modular chemoenzymatic one-pot syntheses in an aqueous medium: Combination of a palladium-catalyzed cross-coupling with an asymmetric biotransformation, Angew. Chem. 2008, 120, 9693-9696; Angew. Chem. Int. Ed. 2008, 47, 9551-9554.
• H. Gröger, FR Dietz: Biocatalytic synthesis of natural and non-natural α-amino acids. In: Wiley Encyclopedia of Chemical Biology, John Wiley & Sons, 2009, 1, 191-204.
• M. Weiß, H. Gröger: Practical Highly Enantioselective Chemoenzymatic One-Pot Synthesis of Short-Chain Aliphatic β-Amino Acid Esters, Synlett 2009, 8, 1251-1254.
• K. Baer, ​​M. Krausser, E. Burda, W. Hummel, A. Berkessel , H. Gröger: Sequential and modular synthesis of chiral 1,3-diols with two stereocenters: access to all four stereoisomers by combining organo- and Biocatalysis, Angew. Chem. 2009, 121, 9519-9522; Angew. Chem. Int. Ed. 2009, 48, 9355-9358.

Web links

• Literature by and about Harald Gröger in the catalog of the German National Library

Individual evidence

1. ↑ biographical data, publications and Academic pedigree of Harald Gröger at academictree.org, accessed on January 1, 2018th
2. ↑ M. Weiß, H. Gröger: Practical Highly Enantioselective Chemoenzymatic One-Pot Synthesis of Short-Chain Aliphatic β-Amino Acid Esters, Synlett 2009, 8, 1251-1254.