Michael S. Waterman

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Michael S. Waterman (born June 28, 1942 in Coquille , Oregon ) is an American pioneer in bioinformatics .

Michael Waterman

Waterman grew up in Bandon (Oregon) and studied mathematics at Oregon State University with a bachelor's degree in 1964 and a master's degree (MS) in 1966. In 1968 he made his master's degree (MA) from Michigan State University , where he received his PhD in probability theory in 1969 with John Kinney ( Some ergodic properties of Multi-Dimensional F-Expansions ). He studied statistical properties of the iteration of functions with the computer, which also led to the first invitations to the Los Alamos National Laboratory . In Los Alamos he also met Temple Smith, who introduced him to bioinformatics. Under the leadership of the Charles DeLisi laboratory, they developed algorithms for sequence alignment and RNA folding. From 1969 he was an assistant professor and later an associate professor at the University of Idaho . From 1975 to 1981 he was at Los Alamos National Laboratories. In 1979/80 he was visiting professor at the University of Hawaii and in 1982 at the Medical School of the University of California, San Francisco . From 1982 he was Professor of Biology, Mathematics and Computer Science at the University of Southern California .

Waterman is responsible for some of the basic algorithms used in genome sequencing . In 1981 he developed the Smith-Waterman algorithm for sequence comparison with Temple F. Smith . In 1988 he published a fundamental paper with Eric Lander on the theory of sequencing, which was widely used, for example, in the Human Genome Project . In the mid-1980s he was also a pioneer with Gary Stormo and others in the development of algorithms that look for patterns ( motifs ) in DNA.

In addition, he also dealt with ergodic theory and algorithmic number theory .

In 2002 he received the Gairdner Foundation International Award . In 1995 he was a Guggenheim Fellow. He is a member of the National Academy of Sciences (2001) and the American Academy of Arts and Sciences (1995). In 2005 he became a member of the Académie des Sciences . The Tel Aviv University awarded him an honorary doctorate in 2011 . For 2015 he was awarded the Dan David Prize .

Fonts

  • Introduction to computational biology , Chapman Hall 1995

Web links

Individual evidence

  1. ↑ Dates of birth according to American Men and Women of Science , Thomson Gale 2005
  2. ^ Mathematics Genealogy Project
  3. ↑ Biography in Jones, Pevzner Introduction to bioinformatics algorithms , MIT Press 2004, p. 209
  4. ↑ Smith, Waterman Identification of Common Molecular Subsequences , Journal of Molecular Biology , Volume 147, 1981, pp. 195-197
  5. ↑ Applied to the so-called mapping problem in your original work
  6. ↑ Lander, Waterman Genomic mapping by fingerprinting random clones: a mathematical analysis , Genomics, Volume 2, 1988, pp. 231-239
  7. ^ Honorary doctorates from Tel Aviv University
personal data
SURNAME Waterman, Michael S.
ALTERNATIVE NAMES Waterman, Michael Spencer (full name)
BRIEF DESCRIPTION American biomathematist
DATE OF BIRTH June 28, 1942
PLACE OF BIRTH Coquille , Oregon