Michael Sieweke

Michael H. Sieweke (* 1963 in Marsberg ) is a German immunologist .

Sieweke studied at the University of Tübingen and received her doctorate from the University of California, Berkeley . He was at EMBO in Heidelberg and completed his habilitation in 1999 at Heidelberg University. He was then research director of the CNRS (from 1999) and group leader at the Center for Immunology in Marseille-Luminy (CIML). From 2014 he was an Einstein Visiting Fellow at the Berlin Center of Health. In 2018 he received a Humboldt Professorship at the TU Dresden , where he works at the Center for Regenerative Therapies (CRTD). He was a visiting researcher at the Australian Regenerative Medicine Institute in Melbourne .

Sieweke researches how immune cells are formed, for example in response to attacks in the immune system . He was able to show that macrophages , like stem cells, can divide indefinitely and that they mobilize gene networks similar to those of embryonic stem cells. Before that, it was assumed that only stem cells could do this. However, the macrophages reproduce in a controlled manner. He researches how these contribute to the maintenance of tissue function and how they are newly formed. Sieweke and colleagues were able to show that and how blood stem cells are stimulated by messenger substances during infections to form new macrophages and other white blood cells . He is researching the application of this discovery, for example, to rebuild the immune system after bone marrow transplantation and tissue regeneration.

He received the silver medal from the Center national de la recherche scientifique (CNRS) and an Advanced Grant from the European Research Council (ERC). Sieweke is a member of the European Molecular Biology Organization (EMBO).

Fonts (selection)

All publications can be found in PUBMED

with Aziz et al. : MafB / c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages, Science, Volume 326, 2009, 5954, PMID 19892988 .
with Sarrazin et al. : MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells, Cell, Volume 138, 2009, PMID 19632180 .
with Judith E. Allen: Beyond Stem Cells: Self-Renewal of Differentiated Macrophages, Science, Volume 342, 2013, 1242974, PMID 24264994 .
with Mossadegh-Keller et al. : M-CSF instructs myeloid lineage fate in single haematopoietic stem cells, Nature, Volume 497, 2014, 4998, PMID 23575636 .
with R. Gentek, K. Molawi: Tissue macrophage identity and self-renewal, Immunol Rev., Volume 262, 2014, pp. 56-73.
with soucie u. a .: Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells, Science, Volume 351, 2016, PMID 26797145 .
with Mossadegh-Keller et al. : Developmental origin and maintenance of distinct testicular macrophage populations, JEM, Volume 214, 2017, PMID 28784628 .

Web links

personal data
SURNAME	Sieweke, Michael
ALTERNATIVE NAMES	Sieweke, Michael H.
BRIEF DESCRIPTION	German immunologist
DATE OF BIRTH	1963
PLACE OF BIRTH	Marsberg