Nefazodone
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Non-proprietary name | Nefazodone | |||||||||||||||
other names |
1- {3- [4- (3-chlorophenyl) piperazin-1-yl] propyl} -3-ethyl-4- (2-phenoxyethyl) -4,5-dihydro-1,2,4-triazole-5- on |
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Molecular formula | C 25 H 32 ClN 5 O 2 | |||||||||||||||
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Molar mass | 470.01 g · mol -1 | |||||||||||||||
Physical state |
firmly |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Nefazodone is one belonging to the class of antidepressants dualserotonergen (DSA) antidepressant . It is a phenylpiperazine derivative that is structurally and partly also in its mode of action similar to the long-known antidepressant trazodone .
Mode of action
The antidepressant effect of nefazodone occurs through two mechanisms. On the one hand it blocks the serotonin 5-HT 2A receptor and on the other hand, to a lesser extent, also the presynaptic reuptake of serotonin.
Nefazodone has no significant affinity for α- or β- adrenoceptor and histamine , dopamine and acetylcholine receptors .
history
In Germany it was sold by Bristol-Myers Squibb from 1997 under the name Nefadar , in the USA it was available under the name Serzone .
The drug was withdrawn from the market in 2003 because of a few cases of severe liver failure .
Individual evidence
- ↑ a b entry on nefazodone. In: Römpp Online . Georg Thieme Verlag, accessed on December 22, 2014.
- ↑ a b c d data sheet Nefazodone hydrochloride from Sigma-Aldrich , accessed on June 15, 2011 ( PDF ).