Netobimin

Structural formula
General
Non-proprietary name	Netobimin
other names	Methoxycarbonyl-amino (nitro-2-propylthio-5-phenylimino) -methyl-1-amino-2-ethanesulfonic acid
Molecular formula	C 14 H 20 N 4 O 7 S 2
External identifiers / databases
CAS number 88255-01-0 EC number 686-284-2 ECHA InfoCard 100.212.027 PubChem 71449 Wikidata Q19297153
Drug information
ATC code	Q P52AC06
Drug class	Anthelmintics
properties
Molar mass	420.5 g · mol -1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Netobimin is an anthelmintic from the sample zimidazole group. It was developed in 1987 by Schering-Plow as a veterinary medicinal product . Netobimin is a prodrug of albendazole .

use

The active ingredient is used to treat gastrointestinal infestations - roundworms , lungworms , tapeworms and flukes in sheep.

Mechanism of action

As with all benzimidazoles, the effect is based on the binding to tubulins of the parasite cell and thus on the inhibition of the formation of microtubules . As a result, vital structural (formation of the cytoskeleton ) and functional processes (absorption of nutrients and transport processes within the parasite cells) are disturbed. After the reserves of the parasite are exhausted, it dies and is excreted after about 2 to 3 days.

Pharmacokinetics

When ingested, netobimin itself is not absorbed, but is quickly converted to albendazole in the rumen and ileum . Albendazole is rapidly absorbed, but is rarely found in the blood plasma due to its rapid processing in the liver ( first-pass effect ). Albendazole sulfoxide is formed in the liver and, like albendazole, is anthelmintically active.

After parenteral administration, netobimin is rapidly absorbed and released into the gastrointestinal tract via the blood and bile . In this respect, it is the same as for oral administration.

Trade names

Monopreparations

Hapadex

Individual evidence

1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
2. ↑ ^{a b} Entry on Netobimin in Pharmawiki , accessed on January 28, 2017.
3. ↑ LS Richards, GL Zimmerman, DW Weber, SW Dawley, MJ Nelson, DJ Schons: Anthelmintic efficacy of netobimin against naturally acquired gastrointestinal nematodes in yearling heifers . In: Veterinary Parasitology . tape 26 , no. 1-2 , December 1987, pp. 79-85 , doi : 10.1016 / 0304-4017 (87) 90078-1 ( PDF ).
4. ↑ LS Richards, GL Zimmerman, MJ Nelson, DJ Schons, SW Dawley: The anthelmintic efficacy of netobimin against experimental infections of Fasciola hepatica in sheep . In: Veterinary Parasitology . tape 26 , no. 1-2 , December 1987, pp. 71-77 , doi : 10.1016 / 0304-4017 (87) 90077-x ( PDF ).
5. ↑ data sheet on pharmazie.com.
6. ↑ ^{a b c} Entry on Netobimin at Vetpharm, accessed on March 8, 2017.