Nieng Yan

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Nieng Yan (born November 21, 1977 in Zhangqiu , Shandong Province ) is a Chinese structural and molecular biologist.

Yan studied biology and biotechnology at Tsinghua University with a bachelor's degree in 2000 and then from Princeton University , where she received her PhD in 2004 with Shi Yigong . Her dissertation was on structural and mechanistic aspects of apoptosis . For this she received the Young Scientist Award for North America in 2005 from the American Association for the Advancement of Science (and its Science magazine ) and from GE Healthcare. As a post-doctoral student at Princeton, she researched the structural characterization of intramembrane proteases . In 2007 she became a professor at Tsinghua University - then the youngest professor at Tsinghua University - and head of the Biology Department. There she studied membrane transport proteins for glucose and sodium and calcium channels. In 2012 she also became an Early Career Scientist at the Howard Hughes Medical Institute (HHMI). She is the Shirley M. Tilghman Professor of Molecular Biology at Princeton University.

She deals with membrane transport and the proteins involved, which she examines, for example, with cryoelectron microscopy with atomic resolution. In particular, her laboratory examined glucose transport ( GLUT ) in humans and various sodium and calcium channels (Nav, Cav) for their structure, dynamic structural changes, disease-causing mutations, the influence of lipids on their activities and the relationship between structure and function, for example during muscle contraction .

In 2015 she received the Young Investigator Award from the Protein Society and the Beverley & Raymond Sackler International Prize in Biophysics. In 2019 she received the Weizmann Women in Science Award and in 2019 became an external member of the National Academy of Sciences .

Fonts (selection)

  • with Y. Shi: Mechanisms of apoptosis through structural biology, Annual Review Cell Development Biology, Volume 21, 2005, pp. 35-56
  • with Z. Wu u. a .: Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry, Nature Structural & Molecular Biology, Volume 13, 2006, pp. 1084-1091
  • with P. Yin u. a .: Structural insights into the mechanism of abscisic acid signaling by PYL proteins, Nature Structural & Molecular Biology, Volume 16, 2009, p. 1230
  • with S. Dang u. a .: Structure of a fucose transporter in an outward-open conformation, Nature, Volume 467, 2010, pp. 734-738
  • with D. Deng u. a .: Structural basis for sequence-specific recognition of DNA by TAL effectors, Science, Volume 335, 2012, pp. 720-723
  • with X. Zhang u. a .: Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel, Nature, Volume 486, 2012, pp. 130-134
  • with L. Sun et al. a .: Crystal structure of a bacterial homologue of glucose transporters GLUT1-4, Nature, Volume 490, 2012, pp. 361-366
  • Structural advances for the major facilitator superfamily (MFS) transporters, Trends in Biochemical Sciences, Volume 38, 2013, pp. 151-159
  • with D. Deng u. a .: Crystal structure of the human glucose transporter GLUT1, Nature, Volume 510, 2014, pp. 121-125
  • with Z. Yan u. a .: Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution, Nature, Volume 517, 2015, pp. 50-55
  • with J. Wu u. a .: Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution, Nature, Volume 537, 2016, p. 191
  • with H. Shen a. a .: Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution, Science, Volume 355, 2017, eaaI4326

Web links

Individual evidence

  1. ↑ Guo Meiping: Two Chinese scientists elected to the National Academy of Sciences , CGTN May 2, 2019
personal data
SURNAME Yan, Nieng
BRIEF DESCRIPTION Chinese molecular biologist
DATE OF BIRTH November 21, 1977
PLACE OF BIRTH Zhangqiu