Patrick A. Baeuerle

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Patrick Alexander Baeuerle (born November 24, 1957 in Friedrichshafen ) is a German molecular biologist and honorary professor for immunology at the University of Munich (LMU) . Since 2015 he has worked for the venture capital company MPM Capital in the USA and Europe . According to a survey by the Institute for Scientific Information (ISI) , Baeuerle was Germany's most cited biomedical researcher of the 1990s.

Life

He studied biology at the University of Konstanz and did his doctorate with Wieland Huttner at the Max Planck Institute for Neurobiology in Martinsried, and at the European Molecular Biology Laboratory (EMBL) in Heidelberg. After a research stay in the USA with Nobel Laureate David Baltimore at MIT's Whitehead Institute in Cambridge, Massachusetts, Baeuerle took on the leadership of a research group at the Gene Center in Martinsried, where he completed his habilitation at the LMU Faculty of Chemistry and Pharmacy. In 1993 he accepted a professorship at the Institute for Biochemistry and Molecular Biology at the Medical Faculty of the Albert Ludwig University in Freiburg. After only three years, Baeuerle moved to the biotechnological industry in San Francisco as head of the search for active pharmaceutical ingredients at Tularik, Inc. (now Amgen ). After his return in 1998 he took over the management board for research and development at Micromet AG in Munich, which was founded by Gert Riethmüller and colleagues at LMU. With the acquisition of CancerVax by Micromet in 2006, Baeuerle became Chief Scientific Officer of the company, which is now listed on the US technology exchange NASDAQ, with headquarters in the US state of Maryland and a research center in Munich. After Micromet was bought by Amgen in 2012, Baeuerle stayed for three years as Vice President for Research and as Site Manager of the newly founded Amgen Research Munich GmbH before moving to the venture capital company MPM Capital in 2015.

Research activities

Baeuerle spent ten years researching the transcription factor NF-kappa-B . He discovered the subunit I-kappa-B, which controls the NF-kappa-B complex, and the subunit p65 / RelA, which mediates gene activation by NF-kappa-B. Further work by Baeuerle clarified the basic activation mechanism of NF-kappa-B, demonstrated the gene switch in the nervous system for the first time, and discovered a role for NF-kappa-B as a redox-sensitive transcription factor and in various inflammatory diseases . Since 1998, Baeuerle has been researching the therapeutic potential of bispecific BiTE antibodies in various cancer diseases. The BiTE antibody blinatumomab (trade name: Blincyto), which he helped to develop, was approved in the USA in 2014 and in the EU in 2015 for the treatment of patients with acute lymphoblastic leukemia . Baeuerle is the author of over 230 scientific articles listed on MedLine . He has also written five children's non-fiction books on biological subjects.

Awards

  • 1983–1987: Scholarship holder of the Max Planck Society and the EMBL
  • 1987–1989: Foreign scholarship from the German Research Foundation
  • 1991–1993: Karl Winnacker Scholarship from Hoechst AG
  • 1993: First prize winner of the Prix Européen de l'Avenir
  • 1997: Ranking by ISI among the 50 most cited biomedical researchers worldwide (38th place)

Works (selection)

  • Biochemical and cell biological studies on the tyrosine sulfation of proteins . Dissertation, University of Munich, 1987
  • Inducible gene expression , 2 volumes. Birkhäuser, Boston / Basel / Berlin 1995, ISBN 3-7643-3800-8

Individual evidence

  1. ↑ Article in FOCUS magazine (2001)
  2. ^ PA Baeuerle, D Baltimore in: Science , 242, 1988, pp. 540-546, PMID 3140380
  3. ^ PA Baeuerle, D Baltimore in: Genes Dev. , 3, 1989, pp. 1689-1698, PMID 2691328
  4. ↑ PA Baeuerle, T Henkel in: Annu Rev Imunol. , 12, 1994, pp. 141-179, PMID 8011280
  5. ↑ PA Baeuerle, Baltimore in: Cell , 87, 1996, pp. 13-20, PMID 8858144
  6. ^ R Bargou et al. in: Science , 321, 2008, pp. 974-977, PMID 18703743
  7. ↑ PA Baeuerle et al. in: Curr. Opin. Mol. Ther. , 11, 2009, pp. 22-30, PMID 19169956
personal data
SURNAME Baeuerle, Patrick A.
ALTERNATIVE NAMES Baeuerle, Patrick Alexander (full name)
BRIEF DESCRIPTION German molecular biologist and honorary professor for immunology at the University of Munich (LMU)
DATE OF BIRTH November 24, 1957
PLACE OF BIRTH Friedrichshafen