Peter C. Gøtzsche

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Peter Christian Gøtzsche (born November 26, 1949 ) is a Danish medical researcher and was director of the Nordic Cochrane Center at Rigshospitalet in Copenhagen , Denmark . Gøtzsche was appointed Professor of Clinical Research Design and Analysis at the University of Copenhagen in 2010 . He co-founded the Cochrane Collaboration in 1993 and has written numerous reviews as such.

research

Based on his research, Gøtzsche concluded that placebos had little effect compared to no treatment at all. He also concluded that many meta-analyzes suffered from data extraction errors. During the evaluation of the data, the Danish research group led by Gøtzsche noted that the data verifiably available in the protocols had not been reproduced to a considerable extent in the publications of the studies.

He and his co-authors have sharply criticized the research methods and interpretations of other scientists, e. B. in meta-analyzes for placebos. Gøtzsche also commented on the meta-analyzes themselves, the editorial independence of medical journals and medical ghostwriting . Also in connection with his criticism of mammography screening, Götzsche published his book Deadly Medicines and Organized Crime: How Big Pharma has Corrupted Healthcare in 2013 in this regard (German translation: Deadly medicine and organized crime: How the pharmaceutical industry corrupts our healthcare system , 2014).

Critique of Mammography Screening

Gøtzsche criticized mammography - screening for the detection of breast cancer by arguing that this could not be justified; his criticism sparked a controversy. His criticism comes from a meta-analysis that he carried out on mammography screening studies and entitled Is screening for breast cancer with mammography justifiable? (in German: "Is breast cancer screening by means of a mammography justifiable?") published in 2000 in the specialist magazine The Lancet . In it he rejected six out of eight studies and argued that their randomization (see randomized controlled study , a quality criterion for studies) was insufficient. In 2006, Gøtzsche's paper on mammography screenings was electronically published in the European Journal of Cancer , even before it was printed. The trade magazine later completely removed the document from its website, without any formal withdrawal, as usual. The paper was later published in the Danish Medical Bulletin , with a brief note from the editor, and Gøtzsche and his co-authors commented on the unilateral withdrawal in the European Journal of Cancer that the authors were not involved.

In 2012 Gøtzsche published Mammography Screening: Truth, Lies and Controversy (in German: “Mammography Screening: Truth, Lies and Opinion Controversy ”).

Criticism of SSRI antidepressants

Gøtzsche criticized the widespread use of SSRI antidepressants in the Guardian in 2014 .

Criticism of reviews on HPV vaccination

In November 2015 EMA announced that it HPV vaccines have examined in a review in which it was examined whether two rarely associated with vaccination reported adverse effects, the complex regional pain syndrome ( Complex Regional Pain Syndrome, CRPS ) and postural orthostatic tachycardia syndrome (POTS), are more common in vaccinated women than unvaccinated women. The evaluation showed that the reporting rates of these diseases observed in the temporal connection with HPV vaccinations corresponded to the expected frequency of occurrence in the age group examined (female adolescents aged 10 to 17 years) and thus there was no indication of a connection.
In December 2015, the Danish scientist Louise Brinth published a criticism of this review. Gøtzsche then submitted a formal complaint to the EMA's official assessment report in May 2016.
In 2018, a Cochrane review rated the vaccination as effective and safe. This review was also criticized by Gøtzsche and his colleagues.

Exclusion from the Cochrane Organization

On September 26, 2018, Gøtzsche was expelled from the Cochrane Organization and his participation in the management committee, to which he was elected in 2017, ended. Four elected leadership members then also left the body under protest and two appointed members were dismissed on parity grounds. The primary reason given for his dismissal was "continued bad behavior that was not compatible with the principles and control of Cochrane ...". Gøtzsche, on the other hand, complains that Cochrane's "growing top-down authoritarian culture and an increasingly commercial business model ... threaten the scientific, moral and social goals of the organization". Gerd Antes from Cochrane Germany sees the situation as a "governance crisis" that calls for transparency and can be mastered with "strict orientation towards the goals and basic principles of Cochrane."

Book publications

  • with Henrik R. Wulff: Rational Diagnosis and Treatment: Evidence-Based Clinical Decision-Making. 4th edition. Wiley, Chichester 2007, ISBN 978-0-470-51503-7 . (Edition 1 + 2 by Wulff only; 1st – 3rd edition. Blackwell, Oxford 2000.)
  • Mammography Screening: Truth, Lies and Controversy . Radcliffe, London 2012, ISBN 978-1-84619-585-3 .
  • Deadly Medicines and Organized Crime: How Big Pharma Has Corrupted Healthcare. Radcliffe, London 2013, ISBN 978-1-84619-884-7 .
    • German: Deadly Medicine and Organized Crime: How the Pharmaceutical Industry Corrupts Our Health Care System . Riva, Munich 2014, ISBN 978-3-86883-438-3 .
  • Deadly Psychiatry and Organized Denial. People's Press. London 2015. ISBN 978-87-7159-623-6 .
    • German: Deadly psychotropic drugs and organized denial: How doctors and the pharmaceutical industry deliberately jeopardize the health of patients. Riva, Munich 2016, ISBN 978-3-86883-756-8 .
  • Good medicine, bad medicine: How to distinguish useful therapies from unnecessary and harmful ones. Riva, Munich, 2018, ISBN 978-3-7423-0440-7

Web links

Individual evidence

  1. ↑ Asbjørn Hrobjartsson, Peter C. Gøtzsche: Hvad er effekten af ​​placebo handling? A systematic oversight of randomized clinical trials with placebo-treated and treated patients [What is the effect of placebo interventions? A systematic review of randomized trials with placebo-treated and untreated patients] . In: Ugeskrift for Læger . tape 164 , no. 3 , January 2002, p. 329-333 , PMID 11816328 .
  2. ↑ Asbjørn Hrobjartsson, Peter C. Gøtzsche: Placebo treatment versus no treatment . In: Cochrane Database of Systematic Reviews . No. 1 , 2003, p. CD003974 , doi : 10.1002 / 14651858.CD003974 , PMID 12535498 .
  3. ↑ A. Hrobjartsson , PC Gotzsche: Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment . In: Journal of Internal Medicine . tape 256 , no. 2 , August 2004, p. 91-90 , doi : 10.1111 / j.1365-2796.2004.01355.x , PMID 15257721 .
  4. Jump up ↑ Peter C. Gøtzsche, Asbjørn Hróbjartsson, Katja Maric, Britta Tendal: Data Extraction Errors in Meta-analyzes That Use Standardized Mean Differences . In: JAMA . tape 298 , no. 4 , July 2007, p. 430-437 , doi : 10.1001 / jama.298.4.430 , PMID 17652297 . There is an error in the article. Comments:
  5. ^ Hugh McGuire, Melissa Edmonds, Jonathan Price: Data Discrepancies in Meta-analyzes That Use Standardized Mean Differences-Reply . In: JAMA . tape 298 , no. 19 , 2007, pp. 2261-2262; Author's reply No. 2262-2263 , doi : 10.1001 / jama.298.19.2261-b , PMID 18029827 .
  6. ^ Peter C. Gøtzsche, Britta Tendal: Data Discrepancies in Meta-analyzes That Use Standardized Mean Differences — Reply . In: JAMA . tape 298 , no. November 19 , 2007, pp. 2262 , doi : 10.1001 / jama.298.19.2262 .
  7. ↑ Gunter Frank : Bad medicine. A rage book. 3. Edition. Knaus-Verlag, 2012, ISBN 978-3-8135-0473-6 , pp. 77–78 and p. 70–79 in total.
  8. ↑ Asbjørn Hróbjartssona, Peter C. Gøtzsche: Unsubstantiated claims of large effects of placebo on pain: serious errors in meta-analysis of placebo analgesia mechanism studies . In: Journal of Clinical Epidemiology . tape 59 , no. 4 , April 2006, p. 336 , doi : 10.1016 / j.jclinepi.2005.05.011 , PMID 16549252 .
  9. ↑ Asbjørn Hróbjartsson, Peter C. Gøtzsche: Powerful spin in the conclusion of wampold et al.'s re-analysis of placebo versus no-treatment trials despite similar results as in the original review . In: Journal of Clinical Psychology . tape 63 , no. 4 , 2007, p. 373-377 , doi : 10.1002 / jclp.20357 , PMID 17279532 .
  10. ↑ Peter C. Gøtzsche: Why we need a broad perspective on meta-analysis . In: British Medical Journal . tape 321 , no. 7261 , September 2000, p. 585-586 , doi : 10.1136 / bmj.321.7261.585 .
  11. ↑ Peter C. Gøtzsche: Ytringsfrihed og redaktionel uafhængighed: Fire fyringer og en kafkask proces . In: Ugeskrift for Læger . tape 170 , no. 18 , 2008, p. 1537 .
  12. ↑ Peter C. Gøtzsche, Jerome P. Kassirer, Karen L. Woolley, Elizabeth Wager, Adam Jacobs, Art Gertel, Cindy Hamilton: What Should Be Done To Tackle Ghostwriting in the Medical Literature? In: PLoS Medicine . tape 6 , no. 2 , 2009, p. e1000023 , doi : 10.1371 / journal.pmed.1000023 , PMID 19192943 , PMC 2634793 (free full text).
  13. ↑ Donald G. McNeil, Jr .: Confronting cancer: Scientist at work - Peter Gotzsche; A Career That Bristles With Against-the-Grain Conclusions. In: New York Times . April 9, 2002, accessed May 30, 2014 .
  14. ↑ Peter C. Gøtzsche, Ole Olsen: Is screening for breast cancer with mammography justifiable? In: The Lancet . tape 355 , January 2000, p. 129+ , doi : 10.1016 / S0140-6736 (99) 06065-1 .
  15. ↑ PH Zahl, PC Gøtzsche, JM Andersen, J. Mæhlen: Withdrawn: Results of the Two-County trial of mammography screening are not compatible with contemporaneous official Swedish breast cancer statistics . In: European Journal of Cancer . March 2006, doi : 10.1016 / j.ejca.2005.12.016 , PMID 16530407 .
  16. ↑ Kerry Grens: Mammography article withdrawal sparks dispute . In: The Scientist . December 2006.
  17. ↑ Per-Henrik Zahl, Peter C. Gøtzsche, Jannike Mørch Andersen, Jan Mæhlen: Results of the Two-County trial of mammography screening are not compatible with contemporaneous official Swedish breast cancer statistics ( Memento from April 24, 2014 in the Internet Archive ) . In: Danish Medical Bulletin . tape 53 , November 2006, p. 438-440 .
  18. ^ Peter C. Gøtzsche, Jan Mæhlen, Per-Henrik Zahl: What is a publication? In: The Lancet . tape 368 , no. 9550 (November – December), 2006, pp. 1854-1856 , doi : 10.1016 / S0140-6736 (06) 69756-0 .
  19. ↑ Peter Gøtzsche: Psychiatric drugs are doing us more harm than good . In: The Guardian . April 30, 2014 ( online ).
  20. ↑ HPV vaccines: EMA confirms evidence does not support that they cause CRPS or POTS. 5th November 2015.
  21. ↑ HPV vaccines: EMA confirms evidence does not support that they cause CRPS or POTS . (PDF; 94 kB). 20th November 2015.
  22. ↑ Louise Brinth: Responsum to Assessment Report on HPV vaccines released by EMA November 26th 2015. online (PDF; 1.3 MB)
  23. ^ Nordic Cochrane Center: Complaint to the European Medicines Agency (EMA) over maladministration at the EMA. (PDF). May 26, 2016.
  24. ↑ M. Arbyn, L. Xu, C. Simoens, PPL Martin-Hirsch: Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors. In: Cochrane Database of Systematic Reviews. Issue 5, 2018, Art. No .: CD009069. doi: 10.1002 / 14651858.CD009069.pub3 .
  25. ↑ L. Jørgensen, PC Gøtzsche, T. Jefferson: The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias. In: BMJ Evidence-Based Medicine. 23, 2018, pp. 165–168, doi: 10.1136 / bmjebm-2018-111012
  26. ^ Statement from Cochrane's Governing Board
  27. ↑ a b Statement from Cochrane's Governing Board - 26th September 2018
  28. ↑ German Network Evidence-Based Medicine: Current discussion about Cochrane. German EbM Network, October 1, 2018, accessed on November 10, 2018 .
  29. ↑ Peter Gøtzsche: Cochrane in Moral Downfall. Gøtzsche Homepage, 2018, accessed on November 10, 2018 .
  30. ↑ Gerd Antes: Cochrane in the media: Explanation of the contradictions and conflicts. Cochrane Germany, September 25, 2018, accessed November 10, 2018 .
personal data
SURNAME Gøtzsche, Peter C.
ALTERNATIVE NAMES Gøtzsche, Peter Christian (full name)
BRIEF DESCRIPTION Danish medical researcher and director of the Nordic Cochrane Center at Rigshospitalet in Copenhagen, Denmark
DATE OF BIRTH November 26, 1949