Peter Ill

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Peter Kranke (born July 10, 1973 in Würzburg ) is an anesthetist and professor of anesthesiology at the University Hospital of Würzburg . Sick is known for conducting clinical studies and systematic reviews in the context of perioperative medicine, clinical research with a focus on evidence-based medicine as well as interventional and observational studies on postoperative nausea and vomiting, among other things . His clinical area of ​​responsibility and interests includes anesthesia and analgesia in obstetrics .

Peter Kranke, anesthetist

Life

Sick studied human medicine from 1994 to 1999 at the Julius Maximilians University of Würzburg and from 1999 to 2000 at the Ruprecht Karls University of Heidelberg and at the Baden Cantonal Hospital in Switzerland (practical year). In 2000 the license to practice medicine followed and in 2001 the doctorate to Dr. med. with "magna cum laude". In 2006 he became a specialist doctor and completed his habilitation in the same year. The theme of the paper was: "Perioperative process optimization through the application of evidence-based medicine and results from outcomes research using the example of avoiding nausea and vomiting after anesthesia". In addition to his job, he took part in a Master of Business course at the Faculty of Economics at the University of Würzburg with an MBA degree in 2005. In 2007 he was appointed senior physician at the Clinic and Polyclinic for Anaesthesiology at the University of Würzburg. He has been Head of Clinical Research there since 2008. In 2009 he accepted a professorship for anesthesiology at the University of Würzburg. In 2013 he was offered a professorship for anesthesiology at the University of Cologne (rejected). In addition to the specialist in anesthesiology, the sick person has the additional qualifications of intensive care medicine , emergency medicine , pain therapy , palliative medicine , acupuncture and medical quality management, as well as various qualifications in connection with the implementation of clinical studies ( investigator , GCP training ). In 2014, Kranke acquired the "University Teaching Bavaria" certificate in the field of university teaching. Since 2016 he has been a lecturer at the clinic and polyclinic for anesthesiology at the University Hospital Würzburg.

The "Clinical Studies Working Group", which is headed by the sick, is able to competently carry out clinical research projects with the aim of approving pharmacological interventions (IMP, phase II or III) or evaluating medical devices due to its diverse experience and networking . Furthermore, the working group creates systematic reviews, including according to the criteria of the Cochrane Collaboration , on interventions in the health care system with accompanying economic benefit assessment.

Scientific contribution

The main focus of the scientific work of the sick was on the one hand observational studies on the incidence and risk factors of nausea and vomiting after anesthesia (postoperative nausea and vomiting; PONV), self-initiated studies on the effectiveness and tolerability of antiemetics and approval studies for antiemetic pharmacotherapy in phases II and III as well as systematic reviews of various interventions in the perioperative context, including numerous antiemetics. In addition, various models of prognostic tools were carried out as part of the prediction of PONV shivering and other endpoints, as well as pharmaco-economic analyzes and investigations into the effects of algorithms on the quality of treatment. The focus on evidence-based medicine in the context of anesthesia soon led to the first Cochrane reviews in the field of perioperative medicine and related areas, which make up a significant focus of the work of the group around the sick and to the development of further Cochrane reviews including their regular updates. The focus of the work on evidence-based medicine led to participation in numerous consensus and guideline committees. In addition to perioperative medicine in general, another focus is on obstetric analgesia and anesthesia. Here in particular on the investigation of alternative methods of obstetric analgesia, e.g. B. Contraindications for performing neuraxial analgesia procedures such as epidural analgesia and their safe implementation. At an early stage, the sick and employees pointed out unusual results from researcher Yoshitaka Fujii. These findings were negated for a long time, but ultimately confirmed by renewed, complex analyzes.

Awards

  • 2018 August Beer Prize of the DGAI
  • 2016 Carl Ludwig Schleich Prize of the DGAI
  • 2004 1st Lilly Quality-of-Life Award, 2013 ESA Metaanalyses Grant.

Memberships in scientific associations

Kranke has been editor of the European Journal of Anaesthesiology since 2010 , member of the expert panel of the journal Anesthesiology, Intensive Care Medicine, Emergency Medicine, Pain Therapy and has held various positions in the European Society of Anesthesiology (including member and later chairman of the Scientific Committee for Evidence-based Medicine and Quality Improvement, Member of the Scientific Committee on Obstetric Anesthesia).

He is a member of the Obstetric Committee (2016–2020) of the World Federation of Societies of Anesthesiologists.

Ill is co-author of the international consensus conferences on the management of nausea and vomiting after anesthesia ( postoperative nausea and vomiting, PONV ) including their regular updates as well as the European recommendation on preoperative sobriety. In the German Society for Anesthesiology, he has held the position of secretary of the Scientific Working Group on Regional Anesthesia and Obstetric Anesthesia since 2015 (since 2017: 2nd speaker of the newly established working group "Obstetric Anesthesia" of the DGAI) and is a member of the DAC's program committee for the field of obstetric anesthesia and the clinical research committee. Since 2011, Ill has been a member of the working group "Revision of Chapter 5 - Human albumin of the cross-sectional guidelines for hemotherapy " of the standing working group "Cross-sectional guidelines for therapy with blood components and plasma derivatives" of the Scientific Advisory Board.

Publications

Books

  • Obstetric anesthesia. Springer, 2017, ISBN 978-3-662-54374-0 .
  • with Leopold Eberhart (Ed.): Nausea and vomiting in the perioperative phase (PONV): Risk assessment, avoidance and therapy in clinical practice . Deutscher Ärzte-Verlag, 2012, ISBN 978-3-7691-1286-3 .
  • Leopold Eberhart, Peter Kranke (Ed.): Fast-Track-Anesthesia. 1st edition. UNI-MED, 2009, ISBN 978-3-8374-1193-5 .

Book chapter

  • with L. Eberhart, M. Anders and M. Reyle-Hahn: Postoperative phase. In: Rolf Rossaint, Christian Werner, Bernhard Zwißler (eds.): The anesthesiology. 3. Edition. Springer Verlag, Berlin / Heidelberg / New York 2012, Chapter 44.
  • with W. Wilhelm: In: W. Wilhelm (Hrsg.): Praxis der Anästhesiologie. 1st edition. Springer Verlag, Berlin / Heidelberg / New York 2018

Technical article

Web links

Individual evidence

  1. ^ Habilitation thesis in the catalog of the German National Library
  2. ↑ University Hospital Würzburg Clinic and Polyclinic for Anaesthesiology
  3. ↑ European Commission: Definition of Investigational Medicinal Products (IMPS)
  4. ↑ CC Apfel, P. Kranke, LHJ Eberhart: Comparison of surgical site and patient's history with a simplified score for the prediction of postoperative nausea and vomiting. In: Anaesthesia. Volume 59, 2004, pp. 1078-1082.
  5. ↑ An International Multicenter Protocol to Assess the single and combined benefits of antiemetic interventions in a Controlled clinical Trial of a 2 ´ 2 ´ 2 ´ 2 ´ 2 ´ 2 factorial design (IMPACT). In: Controlled Clinical Trials. Volume 24, 2003, pp. 736-751.
  6. ↑ C. C Apfel, P. Kranke, MH Katz, C. Goepfert, T. Papenfuss, S. Rauch, R. Heineck, C.-A. Greim, N. Roewer: Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. In: British Journal of Anesthesia. Volume 88, 2002, pp. 659-668.
  7. ↑ CC Apfel, K. Korttila, M. Abdalla, H. Kerger, A. Turan, I. Vedder, C. Zernak, K. Danner, R. Jokela, SJ Pocock, S. Trenkler, M. Kredel, A. Biedler , DI Sessler, N. Roewer: A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. In: NEJM. Volume 350, No. 24, Jun 10, 2004, pp. 2441-2451.
  8. ↑ P. Kranke, KD Röhm, P. Diemunsch, TJ Gan, CC Apfel, L. Eberhart, HS Minkowitz, J. Wallenborn, D. Chassard, G. Lebuffe, GM Fox, MR Tramèr: Intravenous buspirone for the prevention of postoperative nausea and vomiting. In: Eur J Clin Pharmacol. Volume 68, No. 11, Nov 2012, pp. 1465-1472. doi: 10.1007 / s00228-012-1284-8 . Epub 2012 May 1.
  9. ↑ P. Kranke, L. Eberhart, J. Motsch, D. Chassard, J. Wallenborn, P. Diemunsch, N. Liu, D. Keh, H. Bouaziz, M. Bergis, G. Fox, TJ Gan: IV APD421 (amisulpride) prevents postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled, multicentre trial. In: Br J Anaesth. Volume 111, No. 6, Dec 2013, pp. 938-945. doi: 10.1093 / bja / aet251 . Epub 2013 Jul 19.
  10. ↑ P. Kranke, JP Thompson, PL Dalby, LH Eberhart, E. Novikova, BM Johnson, SF Russ, R. Noble, RA Brigandi: Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron . In: British Journal of Anesthesia. Volume 114, No. 3, Mar 2015, pp. 423-429.
  11. ↑ P. Kranke, LH Eberhart, N. Roewer, MR Tramèr: Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering - A quantitative systematic review of randomized controlled trials. In: Anesthesia and Analgesia. Volume 99, No. 3, 2004, pp. 718-727.
  12. ↑ P. Kranke, AM Morin, N. Roewer, H. Wulf, LH Eberhart: The efficacy and safety of transdermal scopolamine for the prevention of postoperative nausea and vomiting: A quantitative systematic review. In: Anesthesia and Analgesia. Volume 95, 2002, pp. 133-143.
  13. ↑ A. Schnabel, L. Eberhart, A. Morin, H. van Aken, N. Roewer, P. Kranke: Efficacy and safety of perphenazine in the prevention of postoperative nausea and vomiting (PONV): A quantitative systematic review. In: Anesthesia & Analgesia. Volume 106, 2008, pp. S-3
  14. ↑ P. Kranke, AM Morin, N. Roewer, LH Eberhart: Dimenhydrinate for prophylaxis of postoperative nausea and vomiting. A meta-analysis of randomized controlled trials. In: Acta Anesthesiologica Scandinavica. Volume 46, 2002, pp. 238-244.
  15. ↑ P. Kranke, LH Eberhart, H. Toker, N. Roewer, H. Wulf, P. Kiefer: A prospective evaluation of the POVOC score for the prediction of postoperative vomiting in children. In: Anesthesia and Analgesia. Volume 105, 2007, pp. 1592-1597.
  16. ↑ LHJ Eberhart, G. Geldner, P. Kranke, AM Morin, A. Schäuffelen, H. Driver, H. Wulf: Development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients. In: Anesthesia and Analgesia. Volume 99, 2004, pp. 1630-1637.
  17. ↑ LH Eberhart, F. Döderlein, G. Eisenhardt, P. Kranke, DI Sessler, A. Torossian, H. Wulf, AM Morin: Independent risk factors for postoperative shivering. In: Anesth Analg. Volume 101, No. 6, Dec 2005, pp. 1849-1857.
  18. ↑ L. Eberhart, T. Koch, P. Kranke, D. Rüsch, A. Torossian, S. Nardi-Hiebl: Activity-based cost analysis of opioid-related nausea and vomiting among inpatients. In: J Opioid Manag. Volume 10, No. 6, Nov-Dec 2014, pp. 415-422.
  19. ↑ P. Kranke, LH Eberhart, TJ Gan, N. Roewer, MR Tramèr: Algorithms for the prevention of postoperative nausea and vomiting: An efficacy and efficiency simulation. In: European Journal of Anaesthesiology. Volume 24, 2007, pp. 856-867.
  20. ^ P. sick, M. Bennett, I. Roeckl-Wiedmann, S. Debus: Hyperbaric oxygen therapy for chronic wounds. In: Cochrane Database Syst Rev. No. 2, 2004.
  21. ↑ P. Ill, MH Bennett, James M. Martyn-St, A. Schnabel, SE Debus: Hyperbaric oxygen therapy for chronic wounds. In: Cochrane Database Syst Rev. No. 4, Apr 18, 2012.
  22. ^ MH Bennett, S. Weibel, J. Wasiak, A. Schnabel, C. French, P. Ill: Hyperbaric oxygen therapy for acute ischaemic stroke. In: Cochrane Database Syst Rev. Nov 12, 2014.
  23. ^ I. Smith, P. Kranke, I. Murat, A. Smith, G. O'Sullivan, E. Søreide, C. Spies, B. in't Veld: European Society of Anaesthesiology. In: Eur J Anaesthesiol. Volume 28, No. 8, Aug 2011, pp. 556-569.
  24. ↑ TJ Gan, P. Diemunsch, AS Habib, A. Kovac, P. Kranke, TA Meyer, M. Watcha, F. Chung, S. Angus, CC Apfel, SD Bergese, KA Candiotti, MT Chan, PJ Davis, VD Hooper, S. Lagoo-Deenadayalan, P. Myles, G. Nezat, BK Philip, MR Tramèr: Consensus guidelines for the management of postoperative nausea and vomiting. In: Anesth Analg. Volume 118, No. 1, Jan 2014, pp. 85-113. doi: 10.1213 / ANE.0000000000000002 .
  25. ^ A. Schnabel, N. Hahn, R. Muellenbach, T. Frambach, A. Hoenig, N. Roewer, P. Kranke: Obstetric analgesia in German clinics. Remifentanil as an alternative to regional analgesia. In: Anaesthesiologist. Volume 60, No. 11, Nov 2011, pp. 995-1001.
  26. ^ A. Schnabel, N. Hahn, J. Broscheit, RM Muellenbach, L. Rieger, N. Roewer, P. Kranke: Remifentanil for labor analgesia: a meta-analysis of randomized controlled trials. In: Eur J Anaesthesiol. Volume 29, No. 4, Apr 2012, pp. 177-185.
  27. ↑ P. Kranke, P. Lavand'homme: The relief of pain in labor and the role of remifentanil. In: Eur J Anaesthesiol. Volume 29, No. 3, Mar 2012, pp. 116-120.
  28. ↑ P. Kranke, CC Apfel, N. Roewer, Y. Fujii: Reported data on granisetron and postoperative nausea and vomiting by Fujii et al. Are incredibly nice! In: Anesth Analg. Vol. 90, No. 4, Apr 2000, pp. 1004-1007.
  29. ↑ P. Kranke, CC Apfel, LH Eberhart, M. Georgieff, N. Roewer: The influence of a dominating center on a quantitative systematic review of granisetron for preventing postoperative nausea and vomiting. In: Acta Anaesthesiol Scand. Volume 45, No. 6, Jul 2001, pp. 659-670.
  30. ↑ CC Apfel, P. Kranke, CA Greim, N. Roewer: Non-systematic serial publishing is not appropriate and ethically questionable. In: Acta Anaesthesiol Scand. Volume 43, No. 4, Apr 1999, pp. 486-487.
  31. ↑ P. Kranke, CC Apfel, CA Greim, N. Roewer: Methodological problems arising from 'serial publishing' on the effectiveness of granisetron in PONV. In: Br J Anaesth. Volume 82, No. 3, Mar 1999, pp. 481-483.
  32. ↑ P. Ill: Putting the record straight: granisetron's efficacy as an antiemetic 'post-Fujii'. In: Anaesthesia. Volume 67, No. 10, Oct 2012, pp. 1063-1067. doi: 10.1111 / j.1365-2044.2012.07318.x . Epub 2012 Aug 16.
  33. ↑ JB Carlisle: The analysis of 168 randomized controlled trials to test data integrity. In: Anaesthesia. Volume 67, No. 5, May 2012, pp. 521-537.
  34. ↑ Carl Ludwig Schleich Prize
  35. ^ European Journal of Anaesthesiology
  36. ↑ Anaesthesiology, Intensive Care Medicine, Emergency Medicine, Pain Therapy
  37. ^ Obstetric Committee of the World Federation of Societies of Anesthesiologists
  38. ↑ Detailed view of the guidelines for intravascular volume therapy in adults
personal data
SURNAME Ill, Peter
BRIEF DESCRIPTION German anesthetist
DATE OF BIRTH July 10, 1973
PLACE OF BIRTH Wurzburg