Phosphomevalonate kinase
| Phosphomevalonate kinase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 191 amino acids | |
| Secondary to quaternary structure | Monomer | |
| Identifier | ||
| Gene name | PMVK | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.7.4.2 , kinase | |
| Response type | Phosphorylation | |
| Substrate | ATP + phosphomevalonate | |
| Products | ADP + diphosphomevalonate | |
| Occurrence | ||
| Parent taxon | Eukaryotes | |
The phosphomevalonate kinase (PMKase) is the enzyme that in eukaryotes the phosphorylation of phosphomevalonate catalyzes a partial step in the biosynthesis of isoprenoids . PMKase is localized in the cytosol of the peroxisomes . In the human body it is mainly expressed in the heart , liver , muscles , kidneys and pancreas .
Catalyzed reaction
-5-Phosphomevalonat.svg){kind=small}
+ ATP ⇔ -5-Pyrophosphomevalonat.svg){kind=small}
+ ADP
5-Phospho- R -mevalonate is converted to 5-Diphospho- R -mevalonate.
Individual evidence
- ↑ 1st homology group at OMA
- ↑ 2nd homology group at OMA
- ↑ UniProt Q15126
- ↑ Kovacs WJ, Tape KN, Shackelford JE, et al. : Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes . In: Histochem. Cell Biol . 127, No. 3, March 2007, pp. 273-90. doi : 10.1007 / s00418-006-0254-6 . PMID 17180682 .
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Cholesterol Biosynthesis - Learning and Teaching Materials
- Jassal / reactome: Mevalonate -5-phosphate is further phosphorylated.