Phosphopantothenate cysteine ligase
| Phosphopantothenate cysteine ligase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 311 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Identifier | ||
| Gene name | PPCS | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 6.3.2.5 , ligase | |
| Response type | condensation | |
| Substrate | ATP / CTP + phosphopantothenate + cysteine | |
| Products | AMP / CMP + PP i + N-phosphopantothenoyl cysteine | |
| Occurrence | ||
| Homology family | PPC synthetase | |
| Parent taxon | Creature | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 79717 | 106564 |
| Ensemble | ENSG00000127125 | ENSMUSG00000028636 |
| UniProt | Q9HAB8 | Q8VDG5 |
| Refseq (mRNA) | NM_001077447 | NM_026494 |
| Refseq (protein) | NP_001070915 | NP_080770 |
| Gene locus | Chr 1: 42.46 - 42.47 Mb | Chr 4: 119.42 - 119.42 Mb |
| PubMed search | 79717 |
106564
|
Phosphopantothenate cysteine ligase (also phosphopantothenate cysteine synthase , short: PPC synthase , gene : PPCS ) is the name of the enzyme that catalyzes the binding of phosphopantothenate to cysteine . This is the second reaction step in the biosynthesis of coenzyme A , which takes place in most living things.
Catalyzed reaction equilibrium
-4%27-Phosphopantothenat.svg)
+ 
+ ATP + AMP + PP i
-4%27-Phosphopantothenoyl-L-cystein.svg)
(R) -4'-phosphopantothenate is condensed on L-cysteine with consumption of ATP . The bacterial enzyme works more effectively with CTP.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Pantothenate Metabolism - Learning and Teaching Materials
