Phthalidisoquinoline alkaloids

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Habit of the Canadian orange root with leaves and a flower
Flower and fruit of the opium poppy

Phthalidisoquinoline alkaloids are natural substances of the isoquinoline alkaloid type.

Occurrence

They are mainly found in the barberry family , the smoke family , the poppy family and the buttercup family . (-) - β-hydrastine was u. a. isolated from the Canadian orange root , while (-) - α-narcotine u. a. from which opium poppies is obtained.

Representative

The representatives of this group include a. (-) - β- hydrastine , (-) - narcotine and (-) - narcotoline . (-) - Narcotoline and (-) - Narcotine (also called noscapine) belong to the opium alkaloids .

  • (-) - hydrastine

  • (-) - Narcotine

  • (-) - Narcotoline

properties

Hydrastine causes the heart to slow down. It is used in ophthalmology for dilation of the pupil and for local anesthesia. In medicine it was used as a hemostatic agent. Hydrastin has a hemostatic and antiseptic effect . Narcotine has reflex-stimulating properties. It also has a pain-relieving and cough-relieving effect.

Individual evidence

  1. ↑ a b c Entry on phthalidisoquinoline alkaloids. In: Römpp Online . Georg Thieme Verlag, accessed on May 8, 2020.
  2. ↑ a b Eberhard Breitmaier: Alkaloids . Springer Fachmedien, Wiesbaden 1997, ISBN 978-3-519-03542-8 , pp. 64 f .