Hydrastine

Structural formula
General
Surname	Hydrastine
other names	(3 S ) -6,7-Dimethoxy-3 - {(5 R ) -6-methyl-7,8-dihydro-5 H - [1,3] dioxolo [4.5 g ] isoquinolin-5-yl } -3 H -2-benzofuran-1-one
Molecular formula	C 21 H 21 NO 6
External identifiers / databases
CAS number 118-08-1 EC number 204-233-0 ECHA InfoCard 100,003,849 PubChem 1309 ChemSpider 1269 Wikidata Q978050
properties
Molar mass	383.40 g mol −1
Physical state	firmly
Melting point	132 ° C
solubility	very bad in water (30 mg l −1 at 20 ° C) easily soluble in acetone and benzene
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 302-312-332 P: 280
Toxicological data	104 mg kg −1 ( LD 50 ,  rat ,  ip )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Hydrastine is a natural substance, more precisely a natural alkaloid .

Occurrence

Canadian orange root ( Hydrastis canadensis ) blooming.

Hydrastine occurs together with berberine in the Canadian orange root ( Hydrastis canadensis ). It was discovered by Alfred P. Durand in 1851 .

use

By oxidation of Hydrastine obtained hydrastinine which earlier than hemostatic agent was used (hemostatic).

See also

• Noscapine

literature

• John Uri Lloyd (1908): Hydrastis canadensis. Lloyd Library, Cincinnati. (PDF; 176 kB)
• Edmund Falk (1890): Hydrastin and Hydrastinin. In: Virchow's archive. Vol. 119, No. 3, pp. 399-446. doi : 10.1007 / BF01882056

Individual evidence

1. ↑ ^{a b} Entry on hydrastine in the ChemIDplus database of the United States National Library of Medicine (NLM) .
2. ↑ ^{a b} Entry on Hydrastine. In: Römpp Online . Georg Thieme Verlag, accessed on June 13, 2014.
3. ↑ ^{a b c} data sheet (1R, 9S) - (-) - β-hydrastine from Sigma-Aldrich , accessed on April 4, 2011 ( PDF ).
4. ↑ American Journal of Pharmacy. Born in 1851, p. 112.