Poly I: C

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Structural formula
Structural formula of Poly I: C
General
Surname Poly I: C
other names
  • Poly (I: C)
  • Polyinosinic acid: polycytidylic acid
  • Poly [(2 R , 3 S , 4 R , 5 R ) -5- (4-amino-2-oxopyrimidin-1-yl) -3,4-dihydroxyoxolan-2-yl] methyl dihydrogen phosphate
CAS number 24939-03-5
PubChem 32744
ATC code

L03 AX07

properties
Physical state

firmly

safety instructions
Please note the restricted labeling requirements for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Poly I: C is a polymer and analog of double stranded RNA .

properties

Poly I: C consists of two polymeric strands between 1.5 and 8 kb in length  , a poly- inosinic acid and a poly- cytidic acid strand, which bond to one another via hydrogen bonds and form a double strand . Poly I: C binds to the toll-like receptor TLR 3 in animals and activates it, which in turn activates the innate immune response . TLR 3 is produced by B cells , macrophages and dendritic cells . The ATC code of poly I: C is L03AX07. As a result of the activation of the TLR 3 by poly I: C, type I interferons are formed. Presumably Poly I: C binds to another receptor. Poly I: C has been studied as an adjuvant in vaccines and to induce apoptosis in cancer cells . An alternative agonist of TLR 3 is RGC100 , a poly- guanylic acid : poly- cytidic acid double strand with lower toxicity and about 100 base pairs in length, since TLR 3 only binds the repeating ribose units independently of the sequence and activation occurs from around 45 base pairs .

Individual evidence

  1. ↑ Data sheet Polyinosinic – polycytidylic acid potassium salt from Sigma-Aldrich , accessed on July 15, 2020 ( PDF ).
  2. ↑ a b A. A. Smorodintsev, OA Aksenov, IK Konstantinova, LM Vil'ner, AV Tinufanov: [Comparative study of the toxicity of poly G poly C and poly I-poly C in different objects]. In: Voprosy virusologii. Number 2, 1978 Mar-Apr, pp. 201-206, PMID 664621 .
  3. ↑ H. Kato, O. Takeuchi, E. Mikamo-Satoh, R. Hirai, T. Kawai, K. Matsushita, A. Hiiragi, TS Dermody, T. Fujita, S. Akira: Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. In: The Journal of Experimental Medicine. Volume 205, number 7, July 2008, pp. 1601–1610, doi : 10.1084 / jem.20080091 , PMID 18591409 , PMC 2442638 (free full text).
  4. Jump up ↑ Y. Li, XL Xu, D. Zhao, LN Pan, CW Huang, LJ Guo, Q. Lu, J. Wang: TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia. In: CNS Neuroscience & Therapeutics. Volume 21, number 11, November 2015, pp. 905-913, doi : 10.1111 / cns.12469 , PMID 26494128 , PMC 4638223 (free full text).
  5. ↑ WHO : L03 AX07
  6. ↑ a b I. Yoshida, M. Azuma: An alternative receptor to poly I: C on cell surfaces for interferon induction. In: Microbiology and Immunology. Volume 57, number 5, May 2013, pp. 329-333, doi : 10.1111 / 1348-0421.12050 , PMID 23668603 .
  7. ^ KA Martins, S. Bavari, AM Salazar: Vaccine adjuvant uses of poly-IC and derivatives. In: Expert Review of Vaccines. Volume 14, number 3, March 2015, pp. 447-459, doi : 10.1586 / 14760584.2015.966085 , PMID 25308798 .
  8. ^ F. Bianchi, S. Pretto, E. Tagliabue, A. Balsari, L. Sfondrini: Exploiting poly (I: C) to induce cancer cell apoptosis. In: Cancer Biology & Therapy. Volume 18, number 10, October 2017, pp. 747-756, doi : 10.1080 / 15384047.2017.1373220 , PMID 28881163 , PMC 5678690 (free full text).
  9. ↑ K. Naumann, R. Wehner, A. Schwarze, C. Petzold, M. Schmitz, J. Rohayem: Activation of dendritic cells by the novel Toll-like receptor 3 agonist RGC100. In: Clinical & Developmental Immunology. Volume 2013, 2013, p. 283649, doi : 10.1155 / 2013/283649 , PMID 24454470 , PMC 3878805 (free full text).