Polylactide-co-glycolide

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Structure of PLGA. x = number of lactic acid units; y = number of glycolic acid units.

Poly (lactide- co- glycolide) ( PLGA ) is a copolymer of the monomers lactide and glycolide , which can be used in different proportions. A polyester is formed from D , L - lactic acid and glycolic acid , which the human body can easily break down.

use

PLGA is used as a surgical suture material (Vicryl).

In the pharmaceutical industry, PLGA is used as an adjuvant for the production of depot pharmaceuticals , especially implants , microparticles or in-situ systems . In the case of the latter, the depot drug form is only created after the drug has been administered in the patient's body, for example by solidifying an injected solution or suspension to form an in-situ implant. In the future, PLGA nanoparticles are also intended to serve as carriers for medicinal substances , with which, for example, zero-order absorption kinetics can be enforced and the first-pass effect can thus be avoided despite oral application .

literature

  • CE Astete, CM Sabliov: Synthesis and characterization of PLGA nanoparticles. In: Journal of Biomaterials Science. Polymer Edition, 17 (3), 2006, pp. 247-289, doi : 10.1163 / 156856206775997322 .
  • Konstantinos Avgoustakis: Polylactic-Co-Glycolic Acid (PLGA). In: Gary E. Wnek, Gary L. Bowlin: Encyclopedia of Biomaterials and Biomedical Engineering. Second Edition, CRC Press 2008, ISBN 978-1-4200-7802-2 , pp. 2259–2269, doi : 10.1201 / b18990-214 , online (PDF; 192 kB), at pharmacy.upatras.gr, accessed on 25 March 2017.
  • Cynthia D'Avila Carvalho Erbetta, Ricardo José Alves and others: Synthesis and Characterization of Poly (D, L-Lactide-co-Glycolide) Copolymer. In: Journal of Biomaterials and Nanobiotechnology. 3, 2012, pp. 208-225, (PDF; 3.04 MB), doi : 10.4236 / jbnb.2012.32027 .

Individual evidence

  1. ^ R. Voigt: Pharmaceutical technology. 10th edition, edited by A. Fahr , Deutscher Apothekerverlag, Stuttgart, 2005, ISBN 978-3-7692-3511-1 , p. 556.
  2. ↑ Nano pills from the inhaler. Deutschlandfunk, June 2008.
  3. ↑ Andreas Schendler: Surface modification of microparticles made of poly (DL-lactic acid-co-glycolic acid) with toll-like receptor agonists: effect on antigen-presenting cells. Dissertation, Freie Univ. Berlin, 2013, pp. 35–72, DNB 1037954742 , urn : nbn: de: kobv: 188-fudissthesis000000094737-9 , (PDF; 14.68 MB).