Prostaglandin D2 receptor
| Prostaglandin D2 receptor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 359 amino acids | |
| Secondary to quaternary structure | multipass transmembrane protein | |
| Identifier | ||
| Gene name | PTGDR | |
| External IDs | ||
| Occurrence | ||
| Homology family | Prostanoid receptors | |
| Parent taxon | Euteleostomi | |
The prostaglandin D 2 receptor , or DP receptor for short , is a G protein-coupled receptor that is anchored in the cell membrane . After binding of prostaglandin D 2 of the extracellular domain, bound to the intracellular domain of activated G αs protein to adenylate cyclase , which in an increase of cAMP results in the cell.
The DP receptor is mainly found in the brain, the retina, some smooth muscle cells ( bronchi , small intestine ) and in blood platelets . Mutations in PTGDR - gene are with asthmatic associated symptoms.