Prostaglandin D2 receptor
|Prostaglandin D2 receptor|
|Properties of human protein|
|Mass / length primary structure||359 amino acids|
|Secondary to quaternary structure||multipass transmembrane protein|
The prostaglandin D 2 receptor , or DP receptor for short , is a G protein-coupled receptor that is anchored in the cell membrane . After binding of prostaglandin D 2 of the extracellular domain, bound to the intracellular domain of activated G αs protein to adenylate cyclase , which in an increase of cAMP results in the cell.
The DP receptor is mainly found in the brain, the retina, some smooth muscle cells ( bronchi , small intestine ) and in blood platelets . Mutations in PTGDR - gene are with asthmatic associated symptoms.