Protein E7 (human papillomavirus 16)

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Protein E7

Existing structure data : PDB  4YOZ

Mass / length primary structure 98 amino acids , 11,022 Da
Identifier
External IDs
Orthologue
HPV 16 HPV 18
Entrez NV
UniProt P03129 P06788
PubMed search NV

Protein E7 is an oncogenic protein of the human papillomavirus 16. It is used together with hTERT in biochemistry and cell biology for the immortalization of cells .

properties

The E7 protein is used to replicate the viral genome . Combined with E6 transformed it host cells . It brings dormant cells to cell division by overcoming the checkpoints of the cell from the G 0 phase to the S phase . It causes the dissociation of E2F1 from pRB , which initiates the gene expression of E2F1-regulated genes of the S-phase. It also inhibits the cellular deacetylation of histones by HDAC1 and HDAC2 . It also inhibits the formation of interferon-α . Protein E7 binds to TMEM173 / STING and thereby inhibits the formation of type I interferons (interferon-α and interferon-β ). It binds divalent zinc ions via its zinc finger . Protein E7 induces the formation of Rad51 and delays DNA repair . It also induces the formation of hTERT .

Web links

Individual evidence

  1. ↑ C. Darimont, K. Macé: Immortalization of human preadipocytes. In: Biochemistry. Volume 85, Number 12, December 2003, ISSN  0300-9084 , pp. 1231-1233, PMID 14739075 .
  2. ^ TM Wise-Draper, SI Wells: Papillomavirus E6 and E7 proteins and their cellular targets. In: Frontiers in bioscience: a journal and virtual library. Volume 13, January 2008, pp. 1003-1017, PMID 17981607 .
  3. ↑ E7 - Protein E7 - Human papillomavirus type 16 - E7 gene & protein. In: uniprot.org. June 20, 2018, accessed May 5, 2018 .
  4. ↑ JW Park, KP Nickel, AD Torres, D. Lee, PF Lambert, RJ Kimple: Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage. In: Radiotherapy and Oncology . Volume 113, number 3, December 2014, pp. 337-344, doi: 10.1016 / j.radonc.2014.08.026 , PMID 25216575 , PMC 4268372 (free full text).
  5. ↑ R. Katzenellenbogen: Telomerase Induction in HPV Infection and Oncogenesis. In: Viruses. Volume 9, number 7, 2017, p. 180, doi: 10.3390 / v9070180 , PMID 28698524 , PMC 5537672 (free full text).