Rainer H. Straub

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Rainer Hans Straub (born March 29, 1960 in Freiburg im Breisgau ) is a German doctor and university lecturer.

Rainer H. Straub

Life

After completing his medical studies at the Albert Ludwigs University of Freiburg (–1988), Rainer H. Straub received his doctorate in 1988. He then worked as a postdoctoral fellow in the Department of Endocrinology and Diabetology at the University Medical Center Freiburg . In 1991 he switched to internal medicine at the Regensburg University Hospital (Director: Jürgen Schölmerich ). Since a research stay at the Institute for Pharmacology at the University of Vienna, he has been concerned with the interaction between the nervous system and the immune system . In 1995 he received his habilitation at the University Hospital Regensburg. He then completed further training as an internal rheumatologist . Since 2001 he is university professor of Experimental Medicine focusing Rheumatology at the University Hospital Regensburg and devotes his research mainly with the question of what role the interactions of the nervous system, endocrine system and immune inflammatory in the formation and maintenance of diseases such as rheumatoid arthritis but other inflammatory diseases, too.

Services

From the very beginning, a central focus of his research has been the direct communication between the nervous system and the immune system, which he examined intensively in the spleen, an interface between the peripheral sympathetic nervous system and the immune system. This neuroimmune synapse of sympathetic nerve fibers and macrophages can have pro-inflammatory and anti-inflammatory tasks depending on the environmental situation.

Then he described the phenomenon of the loss of sympathetic nerve fibers and the increased outgrowth of pain fibers in the inflammation area, for example in rheumatoid arthritis . He also examined changes in the metabolism of steroid hormones , especially sex hormones and glucocorticoids, in chronic inflammatory diseases such as rheumatoid arthritis. It went u. a. about the conversion of biologically inactive steroid hormones into active hormones. Here, there were disturbances in the conversion due to pro-inflammatory factors that fuel the inflammation.

More recently, Straub has increasingly integrated aspects of the body's energy and water balance, the circadian rhythm , and evolutionary medicine into his model for the pathophysiology of chronic inflammatory diseases.

These considerations have also flowed into more recent books.

Rainer H. Straub was spokesman for the German Endocrine Brain Immune Network (GEBIN), the Neuroendocrinoimmunology Working Group of the German Society for Immunology (DGFI), the Neuroendocrine Immune Study Group of the American College of Rheumatology , and a research group of the German Research Foundation (DFG) at the University Hospital Regensburg. From 2009-2010 he was also President of the Scientific Society PsychoNeuroImmunology Research Society (PNIRS) (Journal: Brain Behavior & Immunity ). He was a lecturer at the 44th Nobel Conference at the Karolinska Institute in Stockholm in 2003, held the Philip Hench Lecture of the American College of Rheumatology in 2013 and the Norman Cousins ​​Lecture of the PsychoNeuroImmunology Research Society in 2015.

He is / was a member of the editors of Arthritis & Rheumatism , Rheumatology , Evolution, Medicine, and Public Health , Journal of Endocrinology , Neuroimmunomodulation , Brain Behavior & Immunity and Clinical and Experimental Rheumatology , to name a few examples.

He did his doctorate around 80 colleagues from various departments locally and internationally.

He has received grants from the German Research Foundation, the German Academic Exchange Service (DAAD), the Federal Ministry of Education and Research, the Volkswagen Foundation and the Bavarian State.

Publications

In addition to more than 250 scientific lectures and 400 scientific articles and book chapters, Rainer H. Straub also published several textbooks and specialist books:

  • The Neuroendocrine Immune Network in Aging. Elsevier, 2004, ISBN 978-0-444-51617-6 .
  • Networked thinking in biomedical research. Psycho-Neuro-Endocrino-Immunology. Vandenhoeck & Ruprecht, 2005, ISBN 978-3-525-45050-5 .
  • Textbook of clinical pathophysiology of complex chronic diseases. Volume 1: Physiological Basics Vandenhoeck & Ruprecht, 2006, ISBN 978-3-525-45051-2
  • Textbook of clinical pathophysiology of complex chronic diseases. Volume 2: Special Pathophysiology Vandenhoeck & Ruprecht, 2007, ISBN 978-3-525-45052-9
  • The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae. Elsevier, 2015, ISBN 978-0-12-803321-0
  • Understanding aging, fatigue and inflammation: when the immune system and brain struggle for energy in the body. Springer, 2018, ISBN 978-3-662-55786-0
  • Three memories for the body: How we can explain Alzheimer's dementia, rheumatoid arthritis and obesity. Springer, 2020, ISBN 978-3-662-59131-4

Web links

Individual evidence

  1. ↑ a b c d e f g h i j Rheumanet Regensburg - Straub. Website of Rainer H. Straub at the University of Regensburg; accessed on January 23, 2018.
  2. ^ Rainer H. Straub: A modified method of electronystagmography for recording eye movement during the galvanic vestibular test . PMID 1584588
  3. ↑ Regensburg University Hospital - Rheumatology Research Website of the Regensburg University Hospital - Rheumatology; accessed on January 23, 2018.
  4. ↑ a b Role of peripheral nerve fibers in acute and chronic inflammation in arthritis . In: Nature reviews rheumatology , 9, 2013, pp. 117-126, PMID 23147892
  5. ^ The sympathetic nervous response in inflammation . In: Arthritis Research & Therapy , 16, 2014, p. 504; Review, PMC 4396833 (free full text)
  6. ^ A b Rainer H. Straub, Johannes WJ Bijlsma, Alfonse Masi, Maurizio Cutolo: Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases — The 10-year update. In: Seminars in Arthritis and Rheumatism . Volume 433, 2013, pp. 392-404, doi : 10.1016 / j.semarthrit.2013.04.008 .
  7. ^ A b Rainer H Straub: Interaction of the endocrine system with inflammation: a function of energy and volume regulation. In: Arthritis Research & Therapy. 16, 2014, p. 203, doi : 10.1186 / ar4484 .
  8. ↑ a b Glucocorticoids and chronic inflammation . In: Rheumatology , 55, 2016, pp. Ii6-ii14; Review article; accessed on January 23, 2018.
  9. ^ Rainer H. Straub: Complexity of the bi-directional neuroimmune junction in the spleen. In: Trends in Pharmacological Sciences . Volume 2512, 2004, pp. 640-646, doi : 10.1016 / j.tips.2004.10.007 . (Review)
  10. ^ Rainer H. Straub, Luise Rauch, Alexander Fassold, Torsten Lowin, Georg Pongratz: Neuronally released sympathetic neurotransmitters stimulate splenic interferon-γ secretion from T cells in early type II collagen-induced arthritis. In: Arthritis & Rheumatism. 58, 2008, p. 3450, doi : 10.1002 / art.24030 .
  11. ↑ Peter Härle, Daniel Möbius, Daniel JJ Carr, Jürgen Schölmerich, Rainer H. Straub: An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. In: Arthritis & Rheumatism. 52, 2005, p. 1305, doi : 10.1002 / art.20987 .
  12. ^ Rainer H Straub, Markus Herrmann, Thomas Frauenholz, Gebhard Berkmiller, Bernhard Lang, Jürgen Schölmerich, Werner Falk: Neuroimmune control of interleukin-6 secretion in the murine spleen. Differential β-adrenergic effects of electrically released endogenous norepinephrine under various endotoxin conditions. In: Journal of Neuroimmunology . Volume 711-2, 1996, pp. 37-43, doi : 10.1016 / S0165-5728 (96) 00126-9 .
  13. ↑ LE Miller, HP Jüsten, J. Schölmerich, RH Straub: The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. In: FASEB Journal . Volume 14, Number 13, October 2000, pp. 2097-2107, doi : 10.1096 / fj.99-1082com , PMID 11023994 .
  14. ↑ The Complex Role of Estrogens in Inflammation . In: Endocrine Reviews , 28 (5), 2007, pp. 521-574; Review article; accessed on January 23, 2018.
  15. ↑ CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women . In: Arthritis Research & Therapy , 17, 2015, p. 56; accessed on January 23, 2018.
  16. ^ Rainer H. Straub, Georg Pongratz u. a .: Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis. In: Arthritis & Rheumatism. 58, 2008, p. 976, doi : 10.1002 / art.23385 .
  17. ^ Rainer H. Straub, Leena Paimela u. a .: Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis. In: Arthritis & Rheumatism. 46, 2002, p. 654, doi : 10.1002 / art.10177 .
  18. ↑ RH Straub, HO Besedovsky: evolutionary Integrated, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases. In: FASEB Journal . Volume 17, Number 15, December 2003, pp. 2176-2183, doi : 10.1096 / fj.03-0433hyp , PMID 14656978 .
  19. ↑ Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases . In: Journal of Internal Medicine , 267 (6), pp. 543-560; Review article; accessed on January 23, 2018.
  20. ^ How Energy Shifts Lead to Systemic Illness . In: The Rheumatologist ; Review article; accessed on January 23, 2018.
  21. ^ Rainer H. Straub: Evolutionary medicine and chronic inflammatory state — known and new concepts in pathophysiology. In: Journal of Molecular Medicine. 90, 2012, p. 523, doi : 10.1007 / s00109-012-0861-8 .
  22. ^ Rainer H Straub: Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases. In: Arthritis Research & Therapy. 16, 2014, p. S4, doi : 10.1186 / ar4688 .
  23. ^ A b Evolutionary Medicine Provides Insight into the Chronic Inflammatory State Note Rheumatologists at the 2013 ACR / ARHP Annual Meeting . In: The Rheumatologist on the Hench Lecture at the ACR / ARHP Congress 2013 in San Diego; accessed on January 23, 2018.
  24. ^ A b The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae . Elsevier, 2015, ISBN 978-0-12-803321-0
  25. ↑ The brain and immune system prompt energy shortage in chronic inflammation and aging . In: Nature Reviews Rheumatology , 13, 2017, pp. 743-751; Review article; accessed on January 23, 2018.
  26. ↑ a b Understanding aging, tiredness and inflammation: when the immune system and brain struggle for energy in the body . Springer, 2018, ISBN 978-3-662-55786-0 .
  27. ↑ a b Three memories for the body: How we can explain Alzheimer's dementia, rheumatoid arthritis and obesity. Springer, 2020, ISBN 978-3-662-59131-4
  28. ↑ Spokesman for the German Endocrine Brain Immune Network . Website of the German Endocrine Brain Immune Network; accessed on January 23, 2018.
  29. ^ Speaker of the Neuroendocrinoimmunology Working Group . Website of the German Society for Immunology; accessed on January 23, 2018.
  30. ↑ DFG research group FOR696 . Website of the research group FOR696 at the University of Regensburg; accessed on January 23, 2018.
  31. ^ Past Presidents . PNIRS company website; accessed on January 23, 2018.
  32. ↑ Annual Report of Medicine I . (PDF) Website of the University Hospital Regensburg; accessed on January 23, 2018.
  33. ↑ GEPRIS - DFG funded projects
  34. ↑ Article entries. PubMed .
  35. ↑ Article entries. Google Scholar .
  36. ↑ Textbook Rheumatology, chapter 22 . Google books.
  37. ^ Kelley Textbook of Rheumatology, Chapter 29 . Google books.
  38. ↑ Annual report of the EULAR study group (PDF) Website of the European League Against Rheumatism (EULAR); accessed on January 23, 2018.
personal data
SURNAME Straub, Rainer H.
ALTERNATIVE NAMES Straub, Rainer Hans (full name)
BRIEF DESCRIPTION German physician and university professor
DATE OF BIRTH March 29, 1960
PLACE OF BIRTH Freiburg in Breisgau