Ribose-5-phosphate isomerase
Ribose-5-phosphate isomerase | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 311 amino acids | |
Identifier | ||
Gene name | RPIA | |
External IDs | ||
Enzyme classification | ||
EC, category | 5.3.1.6 , isomerase | |
Response type | Rearrangement | |
Substrate | D-ribulose-5- (di, tri) phosphate | |
Products | D-ribose-5- (di, tri) phosphate | |
Occurrence | ||
Homology family | RPI | |
Parent taxon | Creature | |
Orthologue | ||
human | House mouse | |
Entrez | 22934 | 19895 |
Ensemble | ENSG00000153574 | ENSMUSG00000053604 |
UniProt | P49247 | P47968 |
Refseq (mRNA) | NM_144563 | NM_009075 |
Refseq (protein) | NP_653164 | NP_033101 |
Gene locus | Chr 2: 88.69 - 88.75 Mb | Chr 6: 70.77 - 70.79 Mb |
PubMed search | 22934 |
19895
|
Ribose-5-phosphate isomerase (RPI) is the enzyme that converts ribose-5-phosphate and ribulose-5-phosphate into one another. This reaction equilibrium is part of the pentose phosphate pathway in almost all living things and in the assimilation of carbon dioxide in plants. A lack of RPI by mutations in RPIA - gene in humans is rare and causes leukodystrophy and peripheral neuropathies due to accumulated ribitol and arabitol .
Catalyzed reaction equilibrium
Ribulose-5-phosphate is rearranged to ribose-5-phosphate and vice versa. The di- and triphosphates are also accepted as substrates.
Individual evidence
- ↑ UniProt P49247
- ↑ Huck JH, Verhoeven NM, Struys EA, Salomons GS, Jakobs C, van der Knaap MS: Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy . In: Am. J. Hum. Genet. . 74, No. 4, April 2004, pp. 745-51. doi : 10.1086 / 383204 . PMID 14988808 . PMC 1181951 (free full text).
- ↑ EC 5.3.1.6
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Hexose Monophosphate Pathway - Learning and Teaching Materials