Ruedi Aebersold

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Ruedi Aebersold 2012

Ruedi Aebersold , also Rudolf Hans Aebersold, (born September 12, 1954 in Oberdiessbach ) is a Swiss cell and systems biologist. He is considered one of the pioneers in proteomics .

Life

Aebersold studied at the University of Basel (Diploma 1979) and received his doctorate in cell biology at the Biozentrum of the University of Basel in 1983 ( Structure-function relationships of hybridoma-derived monoclonal antibodies against streptococcal A group polysaccharide ). As a post-doctoral student , he was at Caltech from 1984 to 1986 , where he was a Senior Research Fellow in 1987/88. He was from 1989 to 1993 assistant professor at the University of British Columbia in Vancouver and 1993-1998 Associate Professor and from 1998 professor at the University of Washington in Seattle before of Systems Biology (ISB) in 2000 one of the founders of the Institute Seattle was where he was a professor and led a research group. From 2004 he was a professor at the ETH Zurich , from 2005 at the then newly founded Institute for Molecular Systems Biology (IMSB).

He deals with proteomics, the analysis of the proteins of the cell, their interaction, function and localization (and the respective changes in diseases and in response to external stimuli), in particular with mass spectrometric methods. Aebersold is known for its contributions to targeted proteomics. He developed mass spectroscopic methods (such as selected reaction monitoring , SRM), but also software and standard formats for the data generated in proteomics and is one of the inventors of the Isotope-Coded Affinity Tag (ICAT), a labeling method with stable isotopes in quantitative proteomics ( published 1999). With his team, he mapped (almost completely, under different conditions) the proteome of humans, yeast cells and the tuberculosis pathogen (Mycobacterium tuberculosis), and new proteins were also discovered.

In 2005 he received the HUPO Distinguished Achievement in Proteomic Science Award from the Human Proteome Organization (HUPO), in 2006 the Theodor Bücher Medal from the FEBS and Theodor Bücher Lecture, in 2008 the ABRF Award from the Association of Biomolecular Resource Facilities and in 2010 the Otto Naegeli Prize . In 2012 he received the Thomson Medal Award from the International Mass Spectrometry Conference (IMSC). In 2018 he received the Bijvoet Medal from the Bijvoet Center for Biomolecular Research at the University of Utrecht and the Paracelsus Prize from the Swiss Chemical Society . He became a member of EMBO in 2006 and has been a member of Leopoldina since 2014 . In 2009 he was one of the ISI Highly Cited Researchers.

He is a co-founder of the biotech companies ProteoMediX and Biognosys.

He has been married since 1981 and has three children.

Fonts (selection)

  • with B. Oesch u. a .: A cellular gene encodes scrapie PrP 27-30 protein, Cell, Volume 40, 1985, pp. 735-746
  • with SP Gygi u. a .: Quantitative analysis of complex protein mixtures using isotope ‐ coded affinity tags. Nature Biotechnology, Vol. 17, 1999, pp. 994-999
  • with SA Susin u. a .: Molecular characterization of mitochondrial apoptosis-inducing factor, Nature, Volume 397, 1999, p. 441
  • with SP Gygi, Y. Rochon, BR Franza: Correlation between protein and mRNA abundance in yeast, Molecular and Cellular biology, Volume 19, 1999, pp. 1720-1730
  • with SP Gygi u. a .: Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology, Proc. Nat. Acad. Sci. USA, Vol. 97, 2000, pp. 9390-9395
  • with H. Zhou, JD Watts: A systematic approach to the analysis of protein phosphorylation, Nature Biotechnology, Volume 19, 2001, pp. 375-378.
  • with DR Goodlett: Mass spectrometry in proteomics, Chemical Reviews, Volume 101, 2001, pp. 269-296
  • with DK Han, J. Eng, H. Zhou: Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry, Nature Biotechnology, Volume 19, 2001, p. 946
  • with T. Ideker u. a .: Integrated genomic and proteomic analyzes of a systematically perturbed metabolic network, Science, Volume 292, 2001, pp. 929-934
  • with A. Keller, A. Nesvizhskii, E. Kolker: Empirical statistical model to estimate the accuracy of peptide identifications made by MS / MS and database search., Anal. Chem., Vol. 74, 2002, pp. 5383-5392.
  • with A. Keller u. a .: Empirical statistical model to estimate the accuracy of peptide identifications made by MS / MS and database search, Analytical Chemistry, Volume 74, 2002, pp. 5383-5392
  • with AI Nesvizhskii u. a .: A statistical model for identifying proteins by tandem mass spectrometry, Analytical Chemistry, Volume 75, 2003, pp. 4646-4658
  • with H. Zhang, X.-J. Li, DB Martin: Identification and quantification of N ‐ linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry, Nature Biotechnology, Volume 21, 2003, pp. 660-666.
  • with M. Mann : Mass spectrometry-based proteomics, Nature, Volume 422, 2003, pp. 198-207.
  • with PG Pedrioli u. a .: A common open representation of mass spectrometry data and its application to proteomics research,. Nature Biotechnology, Vol. 22, 2004, 1459-1466
  • with B. Kuster, M. Schirle, P. Mallick: Scoring proteomes with proteotypic peptide probes, Nature Rev. Mol. Cell Biol. Volume 6, 2005, pp. 577-583
  • with B. Domon: Mass spectrometry and protein analysis, Science, Volume 312, 2006, pp. 212-217
  • with Vinzenz Lange, Paola Picotti, Bruno Domon: Selected reaction monitoring for quantitative proteomics: a tutorial, Molecular Systems Biology, Volume 4, 2008, p. 222
  • with P. Picotti a. a .: Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics, Cell, Volume 138, 2009, 795-806
  • with P. Picotti a. a .: High-throughput generation of selected reaction-monitoring assays for proteins and proteomes, Nature Methods, Volume 7, 2010, pp. 43-46.
  • with LC Gillet a. a .: Targeted data extraction of the MS / MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis, Molecular & Cellular Proteomics, Volume 11, 2012, O111.016717.
  • with Paola Picotti: Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions, Nature Methods, Volume 9, 2012, pp. 555-566
  • with A. Bensimon, AJ Heck: Mass spectrometry-based proteomics and network biology, Annual Review of Biochemistry, Volume 81, 2012, pp. 379-405
  • with P. Picotti, B. Bodenmiller: Proteomics meets the scientific method, Nature Methods, Volume 10, 2013, pp. 24-27.
  • with MM Gubin, Hans-Georg R Bäumenee a . a .: Checkpoint blockade cancer immunotherapy targets tumor-specific mutant antigens, Nature, Volume 515, 2014 p. 577
  • with OT Schubert u. a .: Building high-quality assay libraries for targeted analysis of SWATH MS data , Nature Protocols, Volume 10, 2015, pp. 426-441.
  • with M. Mann: Mass-spectrometric exploration of proteome structure and function, Nature, Volume 537, 2016, pp. 347-355

literature

Web links

Individual evidence

  1. ↑ HUPO, Past Award Recipients
  2. ^ Books lecture, Society for Biochemistry and Molecular Biology
  3. ^ Thomson Medal, IMSC 2014
  4. ^ Entry in American Men and Women of Science , Thomson Gale 2004
personal data
SURNAME Aebersold, Ruedi
ALTERNATIVE NAMES Aebersold, Rudolf Hans
BRIEF DESCRIPTION Swiss cell biologist and systems biologist
DATE OF BIRTH September 12, 1954
PLACE OF BIRTH Oberdiessbach