Matthias Mann
Matthias Mann (born October 10, 1959 in Thuine , Lower Saxony) is a German physicist and biochemist who primarily researches mass spectrometry and its applications in proteomics . He is director at the Max Planck Institute for Biochemistry in Martinsried near Munich . The Institute for Scientific Information's “ Highly Cited Researcher ” database lists him as one of the 250 most cited scientists in his field.
Life
Mann studied physics and mathematics at the University of Göttingen . He received his PhD in 1988 from Yale University with Nobel Prize winner John Fenn on mass spectrometry of high molecular weight compounds. He was then a postdoctoral fellow at the University of Southern Denmark in Odense and from 1992 to 1997 group leader at the European Molecular Biology Laboratory (EMBL). From 1998 to 2005 he was a full professor at the University of Southern Denmark. Since 2003 he has been Director at the Max Planck Institute for Biochemistry in Martinsried near Munich and a Scientific Member of the Max Planck Society . But he also does research at the University of Copenhagen . In 2013 Matthias Mann was elected a member of the German Academy of Sciences Leopoldina , and in 2019 a member of the Bavarian Academy of Sciences .
plant
Mann developed a mass spectrometric method to quickly determine the proteins in a body cell. He used the electrospray method of his doctoral supervisor, John Fenn, in which an electrostatic voltage is used to separate the proteins, since thermal evaporation is not possible with proteins as in conventional mass spectrometers.
In 2008 he and his colleagues succeeded in deciphering the 4400 proteins of the yeast cell (determination of the proteome ), and he is working on the international Human Proteome Project , on the complete listing of the proteins in the human body (probably over 100,000 in magnitude). The process also opens up new possibilities in medical diagnostics, as the protein pattern of the cell changes with diseases and can thus serve as a “fingerprint” for them. In particular, the procedure promises to revolutionize cancer diagnostics.
Mann is currently (2011) also using his method to investigate how muscle cells react to insulin.
Honors and prizes
Mann has received numerous awards for his scientific work, including:
- 1999 Biemann Medal from the American Society for Mass Spectrometry
- 2001 Meyenburg Prize
- 2001 Fresenius Prize and Medal for Analytical Chemistry from the Society of German Chemists
- 2006 Science Award Biochemical Analysis of the DGKL
- 2010 Schelling Prize
- 2012 Gottfried Wilhelm Leibniz Prize
- 2012 Louis Jeantet Prize
- 2012 Ernst Schering Prize
- 2012 Körber Prize for European Science
literature
- Max Planck Society (Hg): Handbook of Scientific Members , Munich 2006
- Max Planck Society (Hg): Yearbook 2004, page 85f.
Web links
- Homepage of Mann at the MPI for Biochemistry
- Hanno Charisius : In Search of the Essence of Life , ZEIT Online , August 30, 2012
Individual evidence
- ↑ Member entry by Matthias Mann (with picture) at the German Academy of Natural Scientists Leopoldina , accessed on June 6, 2016.
- ↑ The minimum number corresponds to around 25,000 genes, but each of the around 200 body cells has a different protein pattern
- ↑ Marc Hasse: Matthias Mann: Pioneer of protein research. Abendblatt.de, September 7, 2012, accessed on September 8, 2012 .
| personal data | |
|---|---|
| SURNAME | Man, Matthias |
| BRIEF DESCRIPTION | German physicist and biochemist |
| DATE OF BIRTH | October 10, 1959 |
| PLACE OF BIRTH | Thuine |