Sec61 Translocon α1

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Sec61 Translocon α1
Mass / length primary structure 476 amino acids , 52,265 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 29927 53421
Ensemble ENSG00000058262 ENSMUSG00000030082
UniProt P61619 P61620
Refseq (mRNA) NM_013336.4 NM_016906
Refseq (protein) NP_037468.1 NP_058602
Gene locus Chr 3: 128.05 - 128.07 Mb
PubMed search 29927 53421

Sec61 Translocon α1 (synonym Sec61α1, Sec61A1) is a transmembrane protein in vertebrates . It is part of the translocon (Sec61 translocon) for the import of proteins with K D E L - signal sequence from the cytosol into the endoplasmic reticulum .

properties

Sec61 is a heterotrimer in vertebrates and consists of the three proteins Sec61 Translocon α1 (Sec61A1), Sec61B and Sec61G . Sec61 forms a pore with a closure that is opened for proteins with KDEL signal sequence. Sec61 Translocon α1 binds ribosomes , which means that proteins are passed on to the endoplasmic reticulum directly during translation (through cotranslational protein transport ). Sec61 Translocon α1 can bind SEC62, SEC63 and HSPA5 / BiP, which deliver proteins post-translationally to the endoplasmic reticulum. Sec61 Translocon α1 prevents the uncontrolled outflow of the secondary messenger substance Ca 2+ through the pore from the endoplasmic reticulum.

Individual evidence

  1. ^ S. Lang, J. Benedix, SV Fedeles, S. Schorr, C. Schirra, N. Schäuble, C. Jalal, M. Greiner, S. Hassdenteufel, J. Tatzelt, B. Kreutzer, L. Edelmann, E. Krause, J. Rettig, S. Somlo, R. Zimmermann, J. Dudek: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. In: Journal of cell science. Volume 125, Pt 8 April 2012, pp. 1958–1969, doi : 10.1242 / jcs.096727 , PMID 22375059 , PMC 4074215 (free full text).
  2. ↑ D. Schubert, MC Klein, S. Hassdenteufel, A. Caballero-Oteyza, L. Yang, M. Proietti, A. Bulashevska, J. Kemming, J. Kühn, S. Winzer, S. Rusch, M. Fliegauf, AA Schäffer, S. Pfeffer, R. Geiger, A. Cavalié, H. Cao, F. Yang, Y. Li, M. Rizzi, H. Eibel, R. Kobbe, AL Marks, BP Peppers, RW Hostoffer, JM Puck , R. Zimmermann, B. Grimbacher: Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1). In: The Journal of allergy and clinical immunology. Volume 141, number 4, 04 2018, pp. 1427–1438, doi : 10.1016 / j.jaci.2017.06.042 , PMID 28782633 , PMC 5797495 (free full text).
  3. ↑ S. Haßdenteufel, N. Johnson, AW Paton, JC Paton, S. High, R. Zimmermann: Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. In: Cell Reports. Volume 23, number 5, 05 2018, pp. 1373-1386, doi : 10.1016 / j.celrep.2018.03.122 , PMID 29719251 , PMC 5946456 (free full text).
  4. ^ S. Lang, J. Benedix, SV Fedeles, S. Schorr, C. Schirra, N. Schäuble, C. Jalal, M. Greiner, S. Hassdenteufel, J. Tatzelt, B. Kreutzer, L. Edelmann, E. Krause, J. Rettig, S. Somlo, R. Zimmermann, J. Dudek: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. In: Journal of cell science. Volume 125, Pt 8 April 2012, pp. 1958–1969, doi : 10.1242 / jcs.096727 , PMID 22375059 , PMC 4074215 (free full text).
  5. ↑ S. Haßdenteufel, N. Johnson, AW Paton, JC Paton, S. High, R. Zimmermann: Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. In: Cell Reports. Volume 23, number 5, 05 2018, pp. 1373-1386, doi : 10.1016 / j.celrep.2018.03.122 , PMID 29719251 , PMC 5946456 (free full text).
  6. ↑ D. Schubert, MC Klein, S. Hassdenteufel, A. Caballero-Oteyza, L. Yang, M. Proietti, A. Bulashevska, J. Kemming, J. Kühn, S. Winzer, S. Rusch, M. Fliegauf, AA Schäffer, S. Pfeffer, R. Geiger, A. Cavalié, H. Cao, F. Yang, Y. Li, M. Rizzi, H. Eibel, R. Kobbe, AL Marks, BP Peppers, RW Hostoffer, JM Puck , R. Zimmermann, B. Grimbacher: Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1). In: The Journal of allergy and clinical immunology. Volume 141, number 4, 04 2018, pp. 1427–1438, doi : 10.1016 / j.jaci.2017.06.042 , PMID 28782633 , PMC 5797495 (free full text).