Sec61 Translocon β
Sec61 Translocon β | ||
---|---|---|
other names |
Sec61β |
|
Mass / length primary structure | 96 amino acids , 9,974 Da | |
Identifier | ||
External IDs | ||
Orthologue | ||
human | House mouse | |
Entrez | 10952 | 66212 |
Ensemble | ENSG00000106803 | ENSMUSG00000053317 |
UniProt | P60468 | Q9CQS8 |
Refseq (mRNA) | NM_006808 | NM_024171 |
Refseq (protein) | NP_006799 | NP_077133 |
PubMed search | 10952 |
66212
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Sec61 Translocon β (synonym Sec61β, Sec61B) is a transmembrane protein in vertebrates . It is part of the translocon (Sec61 translocon) for the import of proteins with K D E L - signal sequence from the cytosol into the endoplasmic reticulum .
properties
Sec61 is a heterotrimer in vertebrates and consists of the three proteins Sec61 Translocon α1 ( Sec61A1 ), Sec61B and Sec61G . Sec61 forms a pore with a closure that is opened for proteins with KDEL signal sequence. After translation , the methionine is split off at position 1. It is palmitoylated at the cysteine at position 39 .
literature
- E. Hartmann, T. Sommer, S. Prehn, D. Görlich, S. Jentsch, TA Rapoport: Evolutionary conservation of components of the protein translocation complex. In: Nature . Volume 367, Number 6464, February 1994, pp. 654-657, doi : 10.1038 / 367654a0 , PMID 8107851 .
- JJ Greenfield, S. High: The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. In: Journal of cell science. Volume 112 (Pt 10), May 1999, pp. 1477-1486, PMID 10212142 .