Somatotropin receptor
| Somatotropin receptor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 620 amino acids | |
| Secondary to quaternary structure | Membrane receptor (isoforms GHRfl, GHRtr, GHRd3) | |
| Isoforms | 4th | |
| Identifier | ||
| Gene name | GHR | |
| External IDs | ||
| Occurrence | ||
| Homology family | GHR | |
| Parent taxon | Euteleostomi | |
The somatotropin receptor ( GHR , English growth hormone receptor ) is the protein in the cell membrane of vertebrates to which the hormone somatropin (somatotropin, STH, GH), a growth factor , binds. The receptor belongs to the cytokine receptors . Its main effects are the activation of a JAK-STAT signaling pathway , the expression of insulin-like growth factor 1 and the binding to the tyrosine kinase - coupled receptors SHP-2 . In the growth phase, these cause the body to grow in general and in length and lose fat. Mutations in GHR - gene can and somatropin resistance this to a form of dwarfism , the Laron syndrome lead.
In humans, GHR is mainly produced in the liver and skeletal muscles . Three of the four GHR isoforms are transmembrane receptors ; the soluble isoform is known as somatropin-binding protein (GHBP, English growth hormone binding protein ). It lacks the cytoplasmic domain, and by reversibly binding to somatropin, it acts as a buffer for this hormone in the blood plasma.
See also
Individual evidence
- ↑ UniProt P10912
- ↑ Somatotropin receptor. In: Online Mendelian Inheritance in Man . (English).
Web links
- Jennifer McDowall / Interpro: Protein Of The Month: Growth hormone receptor. (engl.)