T1R1
| Taste receptor type 1 member 1 | ||
|---|---|---|
| other names |
G-protein coupled receptor 70, TS1R1, TAS1R1 |
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| Properties of human protein | ||
| Mass / length primary structure | 821 amino acids | |
| Precursor | 841 amino acids , 93,074 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 80835 | |
| Ensemble | ENSG00000173662 | |
| UniProt | Q7RTX1 | |
| Refseq (mRNA) | NM_138697.3 | |
| Refseq (protein) | NP_619642.2 | |
| PubMed search |
80835
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Taste receptor type 1 member 1 (T1R1) is a protein from the group of G-protein-coupled receptors in humans and part of the receptor for the umami taste.
properties
T1R1 forms a heterodimer with T1R3 . As a heterodimer, it forms the receptor for umami taste and binds the amino acid glutamate . The binding of glutamates is enhanced by 5'- ribonucleotides , such as inosine monophosphate (IMP) and guanosine monophosphate (GMP), while without glutamate they do not activate the receptor. T1R1 is glycosylated . Methional is an allosteric modulator of the taste receptor from T1R1 and T1R3. On human receptors, its potency is exceeded by 3- (methylthio) butanal.
The signal transduction upon activation of T1R1 is via activation of G-proteins . As a result, the phospholipase PLC-β2 is activated, whereby PIP 2 and diacylglycerol are formed. This is followed by activation of the IP3 receptor and an increase in Ca 2+ in the cytosol , whereupon the ion channel TRPM5 is activated.
Individual evidence
- ↑ a b TAS1R1 - Taste receptor type 1 member 1 precursor - Homo sapiens (Human) - TAS1R1 gene & protein. In: uniprot.org. December 15, 2003, accessed September 2, 2018 .
- ↑ E. Sainz, MM Cavenagh, ND Lopez-Jimenez, JC Gutierrez, JF Battey, JK Northup, SL Sullivan: The G-protein coupling properties of the human sweet and amino acid taste receptors. In: Developmental neurobiology. Volume 67, number 7, June 2007, pp. 948-959, doi : 10.1002 / dneu.20403 , PMID 17506496 .
- ↑ G. Nelson, J. Chandrashekar, MA Hoon, L. Feng, G. Zhao, NJ Ryba, CS Zuker: An amino-acid taste receptor. In: Nature . Volume 416, number 6877, March 2002, pp. 199-202, doi : 10.1038 / nature726 , PMID 11894099 .
- ↑ a b X. Li, L. Staszewski, H. Xu, K. Durick, M. Zoller, E. Adler: Human receptors for sweet and umami taste. In: Proceedings of the National Academy of Sciences . Volume 99, number 7, April 2002, pp. 4692-4696, doi : 10.1073 / pnas.072090199 , PMID 11917125 , PMC 123709 (free full text).
- ↑ Toda Y et al: Positive / Negative Allosteric Modulation Switching in an Umami Taste Receptor (T1R1 / T1R3) by a Natural Flavor Compound, Methional . In: Sci Rep . 8, No. 1, August 2018, p. 11796. doi : 10.1038 / s41598-018-30315-x . PMID 30087430 . PMC 6081381 (free full text).
- ↑ a b c C. D. Dotson, S. Vigues, NI Steinle, SD Munger: T1R and T2R receptors: the modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus. In: Current opinion in investigational drugs. Volume 11, Number 4, April 2010, pp. 447-454, PMID 20336593 , PMC 4535793 (free full text).