Tadamitsu Kishimoto

Tadamitsu Kishimoto ( Japanese 岸本忠三 , Kishimoto Tadamitsu ; born May 7, 1939 in Tondabayashi , Osaka Prefecture ) is a Japanese immunologist . He discovered interleukin-6 , an important messenger substance of the immune system, and distinguished himself through significant achievements in the field of signal transduction, ie the processing of signals in cells.

Interleukin-6 plays an important role in communication between different cells of the immune system. A dysregulation of interleukin release is related to certain immune and tumor diseases. Kishimoto examined interleukin-6, its receptor and the following signal cascade (STAT). This work contributed significantly to the understanding of cytokines in general and their mode of action.

Kishimoto not only made important contributions to basic research, but was also able to achieve specific clinical-therapeutic advances through the development of antibodies against interleukin receptors, ie some drugs that are used in certain immune and tumor diseases can be traced back to his research.

Stations

1964 Completion of medical studies in Osaka.
1970–1974 work at Johns Hopkins University in Baltimore.
1979 appointment as professor at Osaka University (temporarily at the Institute for Internal Medicine, temporarily at the Institute for Molecular and Cellular Biology).
From 1997 to 2003 he was President of Osaka University

Awards and honors

Kishimoto receives the Crafoord Prize

1982 Behring Kitasato Prize
1986 Erwin von Bälz Prize
1988 Takeda Prize
1988 Asahi Prize
1990 Appointment as Bunka Kōrōsha, person with special cultural merits
1991 member of the National Academy of Sciences
1992 Sandoz Prize
1996 Avery Landsteiner Prize
1998 Order of Culture
2003 Robert Koch Gold Medal
2005 member of the Leopoldina
2009 Crafoord Prize
2011 Japan Prize (with Toshio Hirano )
2017 King Faisal Prize
2019 Keio Medical Science Prize
2020 Tang Prize in the "Biopharmaceutical Research" category

Selection of major publications

K. Yamasaki, T. Taga, Y. Hirata, H. Yawata, Y. Kawanishi, B. Seed, T. Taniguchi, T. Hirano and T. Kishimoto: Cloning and expression of the human interleukin-6 (BSF-2 / IFN beta 2) receptor . In: Science . Volume 241, No. 4867, August 12, 1988, pp. 825-828.
S. Minamoto, K. Ikegame, K. Ueno, M. Narazaki, T. Naka, H. Yamamoto, T. Matsumoto, H. Saito, S. Hosoe and T. Kishimoto: Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3 . In: Biochem Biophys Res Commun . Volume 237, No. 1, August 8, 1997, pp. 79-83.
M. Hibi, M. Murakami, M. Saito, T. Hirano, T. Taga and T. Kishimoto: Molecular cloning and expression of an IL-6 signal transducer, gp130 . In: Cell . Vol. 63, No. 6, December 21, 1990, pp. 1149-57.
T. Hirano, K. Yasukawa, H. Harada, T. Taga, Y. Watanabe, T. Matsuda, S. Kashiwamura, K. Nakajima, K. Koyama, A. Iwamatsu et al .: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin . In: Nature . Volume 324, No. 6092, 6-12. November 1986, pp. 73-76.

Web links

Commons : Tadamitsu Kishimoto - collection of images, videos and audio files

Individual evidence

↑ Osaka University: 大学の沿革
↑ Member entry by Prof. Dr. Tadamitsu Kishimoto (with picture) at the German Academy of Sciences Leopoldina , accessed on July 15, 2016.
↑ Tang Prize 2020

personal data
SURNAME	Kishimoto, Tadamitsu
ALTERNATIVE NAMES	岸本忠三 (Japanese)
BRIEF DESCRIPTION	Japanese immunologist and discoverer of interleukin-6
DATE OF BIRTH	May 7, 1939
PLACE OF BIRTH	Tondabayashi , Osaka Prefecture

[1] Osaka University: 大学の沿革

[2] Member entry by Prof. Dr. Tadamitsu Kishimoto (with picture) at the German Academy of Sciences Leopoldina , accessed on July 15, 2016.

[3] Tang Prize 2020