Lars Terenius

Lars Yngve Terenius (born July 9, 1940 in Örebro ) is a Swedish pharmacologist and neuroscientist at the Karolinska Institute .

Live and act

Terenius received his doctorate in 1968 from Uppsala University with his thesis Structural aspects on estrogen uptake by genitals of the female mouse .

After working as a professor of pharmacology at Uppsala University (since 1972 or 1977), Terenius received a professorship at the Karolinska Institute near Stockholm in 1989 . He retired in 2008, but (as of 2019) is still scientifically active in the department for clinical neurosciences there.

Terenius developed methods for the detection of receptors using radioactive ligands ( radioreceptor methods , tracer method ), applied these methods to opiates and was able to detect an endogenous , opiate-like substance in the central nervous system for the first time. These substances are now called endorphins . His work on neuromodulation was also recognized .

Terenius' more recent work deals on the one hand with genetic risk factors for mental illnesses such as schizophrenia or alcohol addiction and other dependencies, examined in large patient groups, on the other hand with the cell dynamics of certain molecules, in particular the G-protein-coupled receptor . In particular, potential opioid receptors are of interest here , which are investigated by means of fluorescence correlation spectroscopy in the sub- micrometer and sub- millisecond range.

From 2003 to 2005 Terenius was a member of the Nobel Assembly and the Nobel Committee for the award of the Nobel Prize in Physiology or Medicine .

Awards (selection)

• 1978 Gairdner Foundation International Award
• 1981 Honorary Doctorate from Uppsala University
• 1982 Honorary doctorate from the Technical and Natural Sciences University of Norway
• 1987 Member of the Royal Swedish Academy of Sciences
• 1989 member of the Academia Europaea
• 1999 Foreign Honorary Member of the American Academy of Arts and Sciences
• 2000 Neuronal Plasticity Prize

Web links

• Lars Terenius and Lars Terenius: Experimental addiction research at the Karolinska Institute (ki.se)

Individual evidence

1. ↑ 1974 In: Bryan Bunch and Alexander Hellemans: The history of science and technology: a browser's guide to the great discoveries, inventions, and the people who made them, from the dawn of time to today. Boston: Houghton Mifflin, 2004. ISBN 978-0-618-22123-3 , cited from: 1974 at answers.com, accessed May 13, 2013.
2. ^ Lars Terenius: Structural aspects on estrogen uptake by genitals of the female mouse. Abstracts of Uppsala dissertations in medicine, ISSN  0567-5545 , 59. Uppsala 1968.
3. ^ Jeff Goldberg: Anatomy of a Scientific Discovery. Bantam Books 1988 ISBN 0-553-05261-6 , p. 57.
4. ↑ ^{a b} Æresdoktorer - NTNU. In: ntnu.no. Retrieved February 21, 2016 (Norwegian Bokmål). 
5. ^ Lars Terenius: Characteristics of the “receptor” for narcotic analgesics in synaptic plasma membrane fraction from rat brain. In: Acta Pharmacologica et Toxicologica , Volume 33, Number 5, 1973, pp. 377-384, ISSN  0001-6683 . PMID 4801083 .
6. ↑ International Knowledge Balance Conference, November 28, 2005 in Vienna at bmukk.gv.at
7. ^ Nobel Foundation Directory 2003, pp. 48-50.
8. ↑ Lars Terenius MSc, PhD at the Gairdner Foundation (gairdner.org), accessed on May 12, 2013.
9. ↑ Lars Terenius at the Royal Swedish Academy of Sciences (kva.se), accessed on May 13, 2013.
10. ^ Lars Terenius at Academia Europaea (ae-info.org), accessed on May 13, 2013.
11. ↑ Book of Members 1780 – present (PDF, 348 kB) of the American Academy of Arts and Sciences (amacad.org), accessed on May 12, 2013.
12. ^ Neurosciences. (No longer available online.) In: fondation-ipsen.org. Archived from the original on July 21, 2017 ; accessed on February 6, 2016 .