Testosterone-17 β -dehydrogenase
| Testosterone-17 β -dehydrogenase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 310 amino acids | |
| Identifier | ||
| Gene name | HSD17B1, HSD17B2 and HSD17B3 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 1.1.1.64 , oxidoreductase | |
| Response type | (De) hydrogenation | |
| Substrate | Androstenedione / estrone + NADPH / H + | |
| Products | Testosterone / Estradiol + NADP + | |
| Occurrence | ||
| Parent taxon | Animals, mushrooms | |
The testosterone-17 β -dehydrogenase (17 β -HSD-3) is the enzyme that the last step in the biosynthesis of testosterone catalyzes the hydrogenation of androstenedione . The reaction takes place in vertebrates and some invertebrates , but homologous proteins are also found in parasites and fungi. Mutations in HSD17B3 - gene can 17 β -HSD-3 deficiency , and this to a form of pseudohermaphroditism masculinus lead.
Catalyzed reaction
+ NADP H / H + ⇔ 
+ NADP +
Androstenedione is reduced to testosterone.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Steroid Hormone Metabolism - Learning and Teaching Materials
- Jassal / reactome: Reduction of androstenedione to testosterone
- Sex development disorder 46, XY, due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency. In: Orphanet (Rare Disease Database).