Titia de Lange
Titia de Lange (* 1955 in Rotterdam ) is a Dutch cell biologist and geneticist at Rockefeller University in New York City .
De Lange studied at the University of Amsterdam and obtained a Ph.D. in 1985 from Piet Borst at the Nederlands Kanker Instituut (NKI, Dutch Cancer Institute). in biochemistry . As a postdoctoral fellow , she worked with Harold Varmus at the University of California, San Francisco . She has been a professor at Rockefeller University in New York City since 1990 , initially as an assistant professor and since 1994 as an associate professor . In 1997 she received a full professorship and has been co-director of the Anderson Center for Cancer Research since 2011 . Her research professorship is funded by the American Cancer Society .
De Lange's work broadened our understanding of telomeres , the protected ends of chromosomes . She was able to identify most of the known components of the telomeres and discovered that telomeres form a loop. She discovered the shelterin complex as a further protective mechanism . With her work, de Lange has elucidated the cellular response to dysfunction of the telomeres and was able to show how the telomere-associated proteins control the length of the telomeres.
"Packaging" of the telomeres
Trf2 and Tin2 as components of the telosome / shelterin complex
Shelterin cell cycle
Awards (selection)
- 2000 Corresponding member of the Royal Netherlands Academy of Sciences
- 2001 member of the European Molecular Biology Organization
- 2001 Paul Marks Prize for Cancer Research
- 2003 honorary doctorate from the University of Utrecht
- 2006 Foreign member of the National Academy of Sciences
- 2007 member of the American Academy of Arts and Sciences
- 2007 elected member (Fellow) of the American Association for the Advancement of Science
- 2010 Harvey Lecture
- 2012 HP Heineken Prize for Biochemistry and Biophysics
- In 2013 she was among the first to win the Breakthrough Prize in Life Sciences .
- 2014 Canada Gairdner International Award
- 2015 Honorary Doctorate from the University of Chicago
- 2017 Rosenstiel Award
Web links
- Titia de Lange, Ph.D. and curriculum vitae (PDF file; 150 kB) from Rockefeller University (rockefeller.edu); accessed on February 13, 2016
Individual evidence
- ^ Titia de Lange at the Royal Dutch Academy of Sciences (knaw.nl); accessed on February 13, 2016
- ↑ Book of Members 1780 – present, Chapter D. (PDF; 575 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved May 18, 2019 .
- ↑ How Telomeres Solve the End-Protection Problem at the Harvey Society (harveysociety.org); Retrieved March 30, 2012
- ^ Titia de Lange (1955) at the Royal Dutch Academy of Sciences (knaw.nl); accessed on February 13, 2016
- ↑ Titia de Lange to receive Heineken Prize at Rockefeller University (rockefeller.edu); accessed on May 18, 2019.
| personal data | |
|---|---|
| SURNAME | Lange, Titia de |
| ALTERNATIVE NAMES | Delange, Titia |
| BRIEF DESCRIPTION | Dutch cell biologist and geneticist |
| DATE OF BIRTH | 1955 |
| PLACE OF BIRTH | Rotterdam |