Tolazamide

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Structural formula
Structural formula of tolazamide
General
Surname Tolazamide
other names

1- (hexahydro-1 H -azepin-1-yl) -3- ( p -toluenesulfonyl) urea

Molecular formula C 14 H 21 N 3 O 3 S
Brief description

white odorless solid

External identifiers / databases
CAS number 1156-19-0
EC number 214-588-3
ECHA InfoCard 100.013.262
PubChem 5503
ChemSpider 5302
DrugBank DB00839
Wikidata Q7814101
Drug information
ATC code

A10 BB05

properties
Molar mass 311.40 g mol −1
Physical state

firmly

Melting point

170-173 ° C

solubility
  • practically insoluble in water (65 mg l −1 at 30 ° C)
  • miscible with chloroform
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Tolazamide is a chemical compound from the group of sulfonylureas .

Extraction and presentation

Tolazamide can be obtained by the ammonolysis reaction of methyl p -tolylsulfonyl carbamate with 1- aminohexamethyleneimine .

Tolazemide synthesis

properties

Tolazamide is a white, odorless solid that is practically insoluble in water.

use

Tolazamide is used as an orally administered antidiabetic agent with a plasma half-life of 5-10 hours.

Individual evidence

  1. ↑ a b c d e f Entry on tolazamide in the Hazardous Substances Data Bank , accessed January 3, 2019.
  2. ↑ a b c Datasheet Tolazamide, United States Pharmacopeia (USP) Reference Standard from Sigma-Aldrich , accessed on January 3, 2019 ( PDF ).
  3. ↑ Bibliographic data: DE1196200 (B) - Process for the production of benzene-sulfonylsemicarbazides , accessed on January 3, 2019
  4. ↑ Lexicon of Biology: Tolazamid - Lexicon of Biology , accessed on January 3, 2019
  5. ↑ JUCKER: Progress in Drug Research / progress of drug discovery / Progrès the recherches pharmaceutiques . Birkhäuser, 2013, ISBN 978-3-0348-9311-4 , pp. 287 ( limited preview in Google Book search).