Tritoqualine

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Structural formula
Structural formula of tritoqualine
General
Surname Tritoqualine
other names
  • 4,5,6-triethoxy-7-amino-3- (5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo [4.5 g ] isoquinolin-5-yl ) phthalide
  • Hypostamine
  • 554 L
Molecular formula C 26 H 32 N 2 O 8
External identifiers / databases
CAS number 14504-73-5
PubChem 72145
ChemSpider 65119
DrugBank DB13711
Wikidata Q3539707
properties
Molar mass 500.54 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Tritoqualine is a drug that inhibits the enzyme histidine decarboxylase and is therefore one of the atypical antihistamines . However, this does not have a sedating effect and also has an inhibitory effect on mast cell degranulation. It can be used as a support for the treatment of hives , allergic rhinitis and acute, chronic eczema as well as allergic asthmoid conditions. The drug is contraindicated in the first trimester and in type 1 diabetes and is currently out of trade in Germany .

Trade names

Monopreparations

Inhibostamin (D, except for trade )

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ "The antiallergic Tritoqualin does not sedate" on the website of the Deutsches Ärzteblatt
  3. ↑ a b Pharmacology and Toxicology: for study and practice; with 281 tables . 6., completely revised and exp. Schattauer, Stuttgart New York 2007, ISBN 978-3-7945-2295-8 , pp. 354 ( dnb.de [accessed on March 29, 2017]).
  4. ↑ Randomized, placebo controlled study of tritoqualine (hypostamine *) in the treatment of perennial allergic rhinitis . A. Pradalier, V. Hentschel, S. Prouzeau, D. Legallais, G. Lefrançois. Revue Française d'Allergologie et d'Immunologie Clinique 43: 175-179 (2003).
  5. ↑ a b www.epgonline.org
  6. ↑ “For the time being, no Inhibostamin® for type I diabetes!” On the website of the Deutsches Ärzteblatt