Histidine decarboxylase
Histidine decarboxylase | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 662 amino acids | |
Secondary to quaternary structure | Homodimer | |
Cofactor | Pyridoxal phosphate | |
Identifier | ||
Gene name | HDC | |
External IDs | ||
Enzyme classification | ||
EC, category | 4.1.1.22 , lyase | |
Response type | Decarboxylation | |
Substrate | L -histidine | |
Products | histamine | |
Occurrence | ||
Homology family | Decarboxylase | |
Parent taxon | Animals, bacteria | |
Orthologue | ||
human | House mouse | |
Entrez | 3067 | 15186 |
Ensemble | ENSG00000140287 | ENSMUSG00000027360 |
UniProt | P19113 | P23738 |
Refseq (mRNA) | NM_001306146 | NM_008230 |
Refseq (protein) | NP_001293075 | NP_032256 |
Gene locus | Chr 15: 50.24 - 50.27 Mb | Chr 2: 126.59 - 126.62 Mb |
PubMed search | 3067 |
15186
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The histidine decarboxylase (abbreviated HDC ) is an enzyme , the formation of the biogenic amine and neurotransmitter histamine by elimination of carbon dioxide ( decarboxylation ) of histidine catalyzed . Pyridoxal phosphate (active form of pyridoxine ) bound to the enzyme as a prosthetic group is involved in the catalyzed reaction as a cofactor . The enzymatic decarboxylation of histidine with the aid of histidine decarboxylase, which is the first step in the breakdown of the amino acid histidine and the last in histamine biosynthesis, takes place in animals, plants and many bacteria .
Catalyzed reaction
C 6 H 9 N 3 O 2 → C 5 H 9 N 3 + CO 2
Individual evidence
- ↑ UniProt P19113
- ↑ HM Epps: Studies on bacterial amino-acid decarboxylases: 4. l (-) - histidine decarboxylase from Cl. welchii type A . In: The Biochemical Journal . tape 39 , no. 1 , 1945, ISSN 0264-6021 , p. 42-46 , PMID 16747851 , PMC 1258146 (free full text).
- ↑ E. Sandmeier, TI Hale, P. Christen: Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases . In: European Journal of Biochemistry . tape 221 , no. 3 , May 1, 1994, ISSN 0014-2956 , pp. 997-1002 , PMID 8181483 .
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Histidine Metabolism - Learning and Teaching Materials