Trypan red
Structural formula | |||||||||||||||||||
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General | |||||||||||||||||||
Surname | Trypan red | ||||||||||||||||||
other names | |||||||||||||||||||
Molecular formula | C 32 H 19 N 6 Na 5 O 15 S 5 | ||||||||||||||||||
Brief description |
brown or reddish-brown powder |
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properties | |||||||||||||||||||
Molar mass | 1002.8 g mol −1 | ||||||||||||||||||
Physical state |
firmly |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Trypan red is a derivative of the red azo dye benzopurpurine .
history
In 1901 Paul Ehrlich tested over 100 synthetic dyes for their effect against the pathogen Trypanosoma equinum , which causes Mal de Caderas disease in solipeds , and Trypanosoma brucei , which causes Nagana . The only substance that showed trypanocidal activity was nagana red , a benzopurpurine . However, the efficiency was poor, presumably due to the low water solubility . In 1903 Ludwig Benda von der Cassella Farbwerke was commissioned by Ehrlich to synthesize Trypan red as a more water-soluble derivative of Nagana red with an additional sulfonic acid group . This substance is effective against Trypanosoma equinum , but not against other trypanosomes .
Individual evidence
- ^ Hans Hermann Julius Hager, Franz von Bruchhausen: Hager's manual of pharmaceutical practice . Gabler Wissenschaftsverlage, 1990, ISBN 978-3-540-52688-9 , p. 1108 ( limited preview in the Google book search).
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ^ Paul Ehrlich: Chemotherapeutic Trypanosome Studies. In: Berliner Klinische Wochenschrift . Vol. 44, 1907, pp. 233-236. ( PDF ).
- ↑ W. Sneader: Drug discovery: a history . John Wiley, Chichester 2005, ISBN 9780471899792 .
- ↑ Paul Ehrlich, K. Shiga: Color therapeutic experiments in trypanosomal disease. In: Berlin clinical weekly. Vol. 41, 1904. pp. 329-332. ( PDF ).
- ↑ D. Steverding: The development of drugs for treatment of sleeping sickness: a historical review , Parasit Vectors, 3:15 , 2010, doi : 10.1186 / 1756-3305-3-15 .