Ueli Aebi

from Wikipedia, the free encyclopedia
Ueli Aebi (2011)

Ueli Aebi (born May 31, 1946 in Bern ) is a Swiss structural biologist and co-founder of the Maurice E. Müller Institute for Structural Biology at the Biozentrum of the University of Basel .

Life

Ueli Aebi studied physics , mathematics and molecular biology at the University of Bern and the University of Basel from 1967 to 1974 ; he received his PhD in biophysics in 1977 at the Biozentrum of the University of Basel . After building up his academic career in the USA ( University of California, Los Angeles ; Johns Hopkins University School of Medicine, Baltimore ), he returned to the Biozentrum in 1986 as professor of structural biology. He is co-founder of the Maurice E. Müller Institute for Structural Biology and was its director from 1986 until his retirement in 2011.

Act

Ueli Aebi is one of the pioneers of integrative structural biology as well as mechano- and nanobiology. He dealt with the elucidation of the structure, function and assembly of the cytoskeleton , the nuclear pore complexes (NPC) and amyloid fibrils as they are observed in Alzheimer's disease . He studied the architecture of various supramolecular structures using a combination of light , electron and atomic force microscopy , X-ray crystallography and protein engineering . Aebi determined the spatial structure of the NPC using cryo-electron tomography and image reconstruction methods. His work opened the door to nanomedicine and led to the development of novel nano-instruments for diagnosis, therapy and prevention of tissue diseases.

Awards

Publications (selection)

  • U. Aebi, J. Cohn, EL Buhle, L. Gerace: The Nuclear Lamina Is a Meshwork of Intermediate-Type Filaments . In Nature (London), 323, 1986, pp. 560-564, PMID 3762708
  • R. Reichelt, A. Holzenburg, EL Buhle, Jr., M. Jarnik, A. Engel, U. Aebi: Correlation Between Structure and Mass Distribution of the Nuclear Pore Complex, and of Distinct Pore Complex Components . In J. Cell Biol. , 1990, 110, pp. 883-894, PMID 2324201 .
  • CS Goldsbury, J. Kistler, U. Aebi, T. Arvinte, GJS Cooper: Watching Amyloid Fibrils Grow by Atomic Force Microscopy . In J. Mol. Biol. , 1999, 285, pp. 33-39, PMID 9878384
  • RYM Lim, B. Fahrenkrog, J. Koeser, K. Schwarz-Herion, J. Deng, U. Aebi: Nanomechanical Basis of Selective Gating by the Nuclear Pore Complex . In: Science , 2007, 318, pp. 640-643, PMID 17916694
  • M. Plodinec, M. Loparic, EC Obermann, R. Zanetti-Dallenbach, P. Oertle, JT Hyotyla, U. Aebi, M. Bentires-Ali, RYH Lim, C.-A. Schoenenberger: The Nanomechanical Signature of Breast Cancer . In Nature Nanotechnology , 2012, 7, pp. 757-765; also: Nature 491 ( Nature Outlook 22-Nov-2012, S75-S83), PMID 23085644
  • M. Stolz, R. Gottardi, R. Raiteri, S. Miot, I. Martin, R. Imer, U. Staufer, A. Raducanu, M. Düggelin, W. Baschong, AU Daniels, NF Friederich, A. Aszodi, U. Aebi: Early detection of osteoarthritic and aging articular cartilage in mice and patient samples using AFM. In Nature Nanotechnology , 2009, 4: 186-192; also: Nature Nanotechnology 4 ( News and Views 4 (3): 144-5), PMID 19265849

Web links

Commons : Ueli Aebi  - collection of images, videos and audio files
  • Biography. (PDF; 96 kB) nucleus.img.cas.cz, archived from the original on October 21, 2013 .;
  • Farewell to Ueli Aebi. Swiss Nanoscience Institute, January 26, 2012.;

Individual evidence

  1. ↑ a b High awards for Ueli Aebi. Swiss Nanoscience Institute, April 1, 2011, accessed on April 19, 2019 .
  2. ↑ Anna-Lena Dohrmann: The physics of cancer cells - researchers present a new model for tumor formation . Deutschlandfunk ; on the occasion of the international conference “Physics of Cancer” in Leipzig on October 17, 2011. Accessed on June 18, 2014
  3. ^ Microscopy Society of America in the English language Wikipedia
personal data
SURNAME Aebi, Ueli
BRIEF DESCRIPTION Swiss structural biologist
DATE OF BIRTH May 31, 1946
PLACE OF BIRTH Bern