Subunit 1B of the Arp 2/3 complex
| Subunit 1B of the Arp 2/3 complex | ||
|---|---|---|
|
||
| other names |
p41-ARC |
|
| Properties of human protein | ||
| Mass / length primary structure | 41 kDa / 372 amino acids | |
| Identifier | ||
| Gene names | ARPC1B ARC41 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Eukaryotes | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 10095 | 11867 |
| Ensemble | ENSG00000130429 | ENSMUSG00000029622 |
| UniProt | O15143 | Q9WV32 |
| Refseq (mRNA) | NM_005720 | NM_023142 |
| Refseq (protein) | NP_005711 | NP_075631 |
| Gene locus | Chr 7: 99.37 - 99.39 Mb | Chr 5: 145.11 - 145.13 Mb |
| PubMed search | 10095 |
11867
|
The subunit 1B of the Arp 2/3 complex , shortened p41-ARC or just p41 because of the molar mass of just under kDa , is a structural protein from the SOP2 protein family and functions as one of seven subunits of the Arp 2/3 complex . The protein encoded by the ARPC1B gene on the seventh human chromosome shows strong similarities with subunit 1A . This similarity implies that both proteins may serve as the p41 subunit of the complex.
function
The subunit 1B interacts with Arp2 , Arp3 , p16 , p20 , p21 and p34 and forms the Arp 2/3 complex with them, which plays a crucial role in actin nucleation , the polymerization of G-actin to actin filaments. With its subunits Arp2 and 3 , the complex mimics an actin dimer , which is more stable than the dimer itself and thus serves as a center for further polymerization. The subunit B could be necessary especially for the structure of the complex. Besides, it is an activator, and a substrate for the Aurokinase A , from the family of Aurora kinases .
Individual evidence
- ↑ a b ARPC1B
- ↑ Julia Ehinger: Characterization of Arp 2/3 complex mediated actin reorganization during the invasion of bacterial pathogens , Carolo-Wilhelmina University of Braunschweig, February 20, 2006, p. 9f. (Dissertation to obtain the degree of doctorate in natural sciences)