Subunit 1A of the Arp 2/3 complex
Subunit 1A of the Arp 2/3 complex | ||
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Properties of human protein | ||
Mass / length primary structure | 41.6 kDa / 370 amino acids (isoform 1)
38.6 kDa / 245 amino acids (isoform 2) |
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Identifier | ||
Gene names | ARPC1A SOP2L | |
External IDs | ||
Occurrence | ||
Parent taxon | Eukaryotes | |
Orthologue | ||
human | House mouse | |
Entrez | 10552 | 56443 |
Ensemble | ENSG00000241685 | ENSMUSG00000029621 |
UniProt | Q92747 | Q9R0Q6 |
Refseq (mRNA) | NM_006409 | NM_019767 |
Refseq (protein) | NP_006400 | NP_062741 |
Gene locus | Chr 7: 99.33 - 99.37 Mb | Chr 5: 145.08 - 145.11 Mb |
PubMed search | 10552 |
56443
|
The subunit 1A of the Arp 2/3 complex is a protein of SOP2 family of proteins and probably functions as a subunit p41 of the Arp 2/3 complex . It has a great structural similarity to subunit 1B of the Arp 2/3 complex , so that it is assumed that both proteins can serve as subunit p41. The protein is encoded by the ARPC1A gene on human 7th chromosome .
function
The protein forms the Arp 2/3 complex together with the proteins Arp2 , Arp3 , ARPC2 , ARPC3 , ARPC4 and ARPC5 . This protein complex is important in actin nucleation - the formation of actin filaments from G-actin. Presumably, the subunits Arp2 and Arp3 mimic an actin dimer , which is more stable than the dimer itself and thus serves as a center for further polymerization. It is possible that the p41 subunit is crucial for the structure of the complex.