Subunit 4 of the Arp 2/3 complex

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Subunit 4 of the Arp 2/3 complex
Subunit 4 of the Arp 2/3 complex
other names

p20-ARC

Existing structural data : 2P9N , 1TYQ , 1U2V , 4JD2 , 3DXK , 3UKU , 3UKR , 2P9P , 2P9K , 2P9U , 3ULE , 3RSE , 2P9S , 2P9I , 4XF2 , 2P9L , 1K8K , 3DXM , 4XEI

Properties of human protein
Mass / length primary structure 9.5 to 21.6 kDa / 78 to 625 amino acids (depending on isoform)
Identifier
Gene names ARPC4 ARC20
External IDs
Orthologue
human House mouse
Entrez 10093 68089
Ensemble ENSG00000241553 ENSMUSG00000079426
UniProt P59998 P59999
Refseq (mRNA) NM_001024959 NM_001170485
Refseq (protein) NP_001020130 NP_001163956
Gene locus Chr 3: 9.79 - 9.81 Mb Chr 6: 113.38 - 113.39 Mb
PubMed search 10093 68089

The subunit 4 of the Arp 2/3 complex , abbreviated p20-ARC or just p20 (because of the molar mass of around 20 kDa ) is a structural protein and together with six other proteins forms the Arp 2/3 complex . The protein is encoded by the ARPC4 gene on the third human chromosome .

function

The subunit 4 of the Arp 2/3 complex interacts with the proteins Arp2 , Arp3 , p16 , p21 , p34 and p40 and together with them forms the Arp 2/3 complex, which plays an important role in the formation of actin filaments from G- Actin plays. The complex acts namely as a center for further actin nucleation by an actin dimer mimics the two subunits Arp 2 and 3, but it is more stable than the dimer itself. The subunit 4 seems to have a high affinity for actin, which is necessary for the function of the complex.

Individual evidence

  1. ↑ a b Julia Ehinger: Characterization of Arp 2/3 complex mediated actin reorganization during the invasion of bacterial pathogens , Carolo-Wilhelmina University of Braunschweig, February 20, 2006, p. 9f. (Dissertation to obtain the degree of doctorate in natural sciences)
  2. ↑ a b ARPC4