William L. Jorgensen

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William L. Jorgensen

William L. Jorgensen (born October 5, 1949 in New York City ) is an American chemist ( organic chemistry , theoretical chemistry ).

Jorgensen studied at Princeton University with a bachelor's degree in 1970 and studied chemical physics at Harvard University in 1975 with Elias James Corey with his thesis Computer assisted synthetic analysis. Theoretical studies of polycyles containing small rings received his doctorate . From 1975 he was Assistant Professor and later Professor of Organic Chemistry at Purdue University , from 1985 as HC Brown Professor of Chemistry. In 1990 he became CP Whitehead Professor of Chemistry at Yale University .

He deals with theoretical organic chemistry, computer-aided synthesis and design, especially of potential drugs and molecular computer simulation of liquids and solutions as well as reaction mechanisms.

The subjects of drug research included HIV-1 reverse transcriptase in HIV and macrophage migration inhibitory factor (MIF).

In 2015 he received the Tetrahedron Prize . In 1990 he was an Arthur C. Cope Scholar. In 2012 he received the ACS Hildebrand Award in the Theoretical and Experimental Chemistry of Liquids , in 2004 the Sato Memorial International Award from the Pharmaceutical Society of Japan and the Award in Computational Biology from the International Society for Quantum Biology and Pharmacology, and in 1998 the ACS Award for Computers in Chemical & Pharmaceutical Research.

He is a member of the American Association for the Advancement of Science and the Connecticut Academy. From 1979 to 1981 he was a Sloan Research Fellow . In 2001 he was President of the International Society of Quantum Biology and Pharmacology. In 2011 he became a member of the National Academy of Sciences and in 2007 of the American Academy of Arts and Sciences . In 2010 he became a member of the International Academy of Quantum Molecular Science . In 2009 he became a Fellow of the American Chemical Society . In 1978 he was Dreyfuß Foundation Teacher Scholar. In 1998 he received the ACS Award for Computers in Chemical and Pharmaceutical Research .

Fonts

  • The Many Roles of Computation in Drug Discovery, Science, Volume 125, 2004, pp. 1813-1818
  • with J. Tirado-Rives: Potential energy functions for atomic-level simulations of water, and organic and biomolecular systems, Proc. Nat. Acad. Sci. USA, Vol. 102, 2005, pp. 6665-6670
  • with LL Thomas: Perspective on Free-Energy Perturbation Calculations for Chemical Equilibria, J. Chem. Theory Comput., Volume 4, 2008, pp. 869-876.
  • Efficient Drug Lead Discovery and Optimization, Acc. Chem. Res., Vol. 42, 2009, pp. 724-733
  • with O. Acevedo: Advances in QM / MM Simulations for Organic and Enzymatic Reactions, Acc. Chem. Res., Vol. 43, 2010, pp. 142-151.

Web links

Individual evidence

  1. ↑ Life data according to American Men and Women of Science, Thomson Gale 2004
  2. ^ Biographical data, publications and academic family tree of William L. Jorgensen at academictree.org, accessed on February 15, 2018.
personal data
SURNAME Jorgensen, William L.
BRIEF DESCRIPTION American chemist
DATE OF BIRTH October 5, 1949
PLACE OF BIRTH New York City