Long-chain fatty acid transport protein 4: Difference between revisions

SLC27A4
Identifiers
Aliases	SLC27A4, ACSVL4, FATP4, IPS, solute carrier family 27 member 4
External IDs	OMIM: 604194; MGI: 1347347; HomoloGene: 68437; GeneCards: SLC27A4; OMA:SLC27A4 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,361,470 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	29,707,534 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; prefrontal cortex; ; Brodmann area 9; ; hypothalamus; ; skin of abdomen; ; cingulate gyrus; ; oral cavity; ; right lobe of liver; ; substantia nigra;
	Top expressed in
	lip; ; jejunum; ; duodenum; ; ileum; ; esophagus; ; pontine nuclei; ; skin of abdomen; ; medial dorsal nucleus; ; medial geniculate nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	long-chain fatty acid-CoA ligase activity; nucleotide binding; fatty acid transmembrane transporter activity; ligase activity; catalytic activity; very long-chain fatty acid-CoA ligase activity; long-chain fatty acid transporter activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; plasma membrane; microvillus; brush border membrane; endoplasmic reticulum;
Biological process	lipid transport; response to nutrient; lipid metabolism; medium-chain fatty acid transport; very long-chain fatty acid metabolic process; fatty acid transport; fatty acid metabolic process; long-chain fatty acid import into cell; very long-chain fatty acid catabolic process; metabolism; long-chain fatty acid metabolic process; skin development; long-chain fatty acid transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	10999
	26569
	ENSG00000167114
	ENSMUSG00000059316
	Q6P1M0
	Q91VE0
	NM_005094
	NM_011989
	NP_005085; NP_005085.2
	NP_036119
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 02:56, 28 March 2022

Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene.^[5]^[6] This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A.^[7] It is debated whether it is also a fatty acid transporter at the plasma membrane.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167114 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059316 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fitscher BA, Riedel HD, Young KC, Stremmel W (Dec 1998). "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 381–5. doi:10.1016/s0167-4781(98)00231-0. PMID 9878842.
^ "Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4".
^ Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA (Mar 2005). "Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice". The Journal of Biological Chemistry. 280 (12): 11948–54. doi:10.1074/jbc.M412629200. PMID 15653672.
^ Watkins PA (Jan 2008). "Very-long-chain acyl-CoA synthetases". The Journal of Biological Chemistry. 283 (4): 1773–7. doi:10.1074/jbc.R700037200. PMID 18024425.

Further reading[edit]

Hirsch D, Stahl A, Lodish HF (Jul 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.
Stahl A, Hirsch DJ, Gimeno RE, Punreddy S, Ge P, Watson N, Patel S, Kotler M, Raimondi A, Tartaglia LA, Lodish HF (Sep 1999). "Identification of the major intestinal fatty acid transport protein". Molecular Cell. 4 (3): 299–308. doi:10.1016/S1097-2765(00)80332-9. PMID 10518211.
Gertow K, Bellanda M, Eriksson P, Boquist S, Hamsten A, Sunnerhagen M, Fisher RM (Jan 2004). "Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome". The Journal of Clinical Endocrinology and Metabolism. 89 (1): 392–9. doi:10.1210/jc.2003-030682. PMID 14715877.
Gertow K, Pietiläinen KH, Yki-Järvinen H, Kaprio J, Rissanen A, Eriksson P, Hamsten A, Fisher RM (Jun 2004). "Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance". Diabetologia. 47 (6): 1118–25. doi:10.1007/s00125-004-1417-4. PMID 15168018.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, Watkins PA, Stremmel W, Füllekrug J (Nov 2006). "Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4". Journal of Cell Science. 119 (Pt 22): 4678–88. doi:10.1242/jcs.03280. PMID 17062637.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167114 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059316 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9878842-5] Fitscher BA, Riedel HD, Young KC, Stremmel W (Dec 1998). "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 381–5. doi:10.1016/s0167-4781(98)00231-0. PMID 9878842.

[entrez-6] "Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4".

[pmid15653672-7] Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA (Mar 2005). "Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice". The Journal of Biological Chemistry. 280 (12): 11948–54. doi:10.1074/jbc.M412629200. PMID 15653672.

[pmid18024425-8] Watkins PA (Jan 2008). "Very-long-chain acyl-CoA synthetases". The Journal of Biological Chemistry. 283 (4): 1773–7. doi:10.1074/jbc.R700037200. PMID 18024425.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Long-chain fatty acid transport protein 4''' is a [[protein]] that in humans is encoded by the ''SLC27A4'' [[gene]].<ref name="pmid9878842">{{cite journal | vauthors = Fitscher BA, Riedel HD, Young KC, Stremmel W | title = Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4) | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1443 | issue = 3 | pages = 381–5 | date = Dec 1998 | pmid = 9878842 | doi = 10.1016/s0167-4781(98)00231-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10999}}</ref> This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A.<ref name="pmid15653672">{{cite journal | vauthors = Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA | title = Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice | journal = The Journal of Biological Chemistry | volume = 280 | issue = 12 | pages = 11948–54 | date = Mar 2005 | pmid = 15653672 | doi = 10.1074/jbc.M412629200 | doi-access = free }}</ref> It is debated whether it is also a fatty acid transporter at the plasma membrane.<ref name="pmid18024425">{{cite journal | vauthors = Watkins PA | title = Very-long-chain acyl-CoA synthetases | journal = The Journal of Biological Chemistry | volume = 283 | issue = 4 | pages = 1773–7 | date = Jan 2008 | pmid = 18024425 | doi = 10.1074/jbc.R700037200 | doi-access = free }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+== See also ==
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 27 (fatty acid transporter), member 4
- | HGNCid = 10998
- | Symbol = SLC27A4
- | AltSymbols =; ACSVL4; FATP4
- | OMIM = 604194
- | ECnumber =
- | Homologene = 68437
- | MGIid = 1347347
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0015245 |text = fatty acid transporter activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0015908 |text = fatty acid transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10999
-    | Hs_Ensembl = ENSG00000167114
-    | Hs_RefseqProtein = NP_005085
-    | Hs_RefseqmRNA = NM_005094
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 9
-    | Hs_GenLoc_start = 130142661
-    | Hs_GenLoc_end = 130163322
-    | Hs_Uniprot = Q6P1M0
-    | Mm_EntrezGene = 26569
-    | Mm_Ensembl = ENSMUSG00000059316
-    | Mm_RefseqmRNA = NM_011989
-    | Mm_RefseqProtein = NP_036119
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 29624689
-    | Mm_GenLoc_end = 29639531
-    | Mm_Uniprot = Q3TD48
-  }}
-}}
-'''Solute carrier family 27 (fatty acid transporter), member 4''', also known as '''SLC27A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10999| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==See also==
 * [[Solute carrier family]]
-==References==
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Hirsch D, Stahl A, Lodish HF | title = A family of fatty acid transporters conserved from mycobacterium to man | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8625–9 | date = Jul 1998 | pmid = 9671728 | pmc = 21126 | doi = 10.1073/pnas.95.15.8625 | bibcode = 1998PNAS...95.8625H | doi-access = free }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Stahl A, Hirsch DJ, Gimeno RE, Punreddy S, Ge P, Watson N, Patel S, Kotler M, Raimondi A, Tartaglia LA, Lodish HF | title = Identification of the major intestinal fatty acid transport protein | journal = Molecular Cell | volume = 4 | issue = 3 | pages = 299–308 | date = Sep 1999 | pmid = 10518211 | doi = 10.1016/S1097-2765(00)80332-9 | doi-access = free }}
-| citations =
-*{{cite journal  | author=Hirsch D, Stahl A, Lodish HF |title=A family of fatty acid transporters conserved from mycobacterium to man. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8625-9 |year= 1998 |pmid= 9671728 |doi=  }}
+* {{cite journal | vauthors = Gertow K, Bellanda M, Eriksson P, Boquist S, Hamsten A, Sunnerhagen M, Fisher RM | title = Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 1 | pages = 392–9 | date = Jan 2004 | pmid = 14715877 | doi = 10.1210/jc.2003-030682 | doi-access = free }}
-*{{cite journal  | author=Fitscher BA, Riedel HD, Young KC, Stremmel W |title=Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4). |journal=Biochim. Biophys. Acta |volume=1443 |issue= 3 |pages= 381-5 |year= 1999 |pmid= 9878842 |doi=  }}
+* {{cite journal | vauthors = Gertow K, Pietiläinen KH, Yki-Järvinen H, Kaprio J, Rissanen A, Eriksson P, Hamsten A, Fisher RM | title = Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance | journal = Diabetologia | volume = 47 | issue = 6 | pages = 1118–25 | date = Jun 2004 | pmid = 15168018 | doi = 10.1007/s00125-004-1417-4 | doi-access = free }}
+* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
-*{{cite journal  | author=Stahl A, Hirsch DJ, Gimeno RE, ''et al.'' |title=Identification of the major intestinal fatty acid transport protein. |journal=Mol. Cell |volume=4 |issue= 3 |pages= 299-308 |year= 1999 |pmid= 10518211 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, Watkins PA, Stremmel W, Füllekrug J | title = Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4 | journal = Journal of Cell Science | volume = 119 | issue = Pt 22 | pages = 4678–88 | date = Nov 2006 | pmid = 17062637 | doi = 10.1242/jcs.03280 | doi-access = free }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Gertow K, Bellanda M, Eriksson P, ''et al.'' |title=Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 1 |pages= 392-9 |year= 2004 |pmid= 14715877 |doi=  }}
-*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
-*{{cite journal  | author=Gertow K, Pietiläinen KH, Yki-Järvinen H, ''et al.'' |title=Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance. |journal=Diabetologia |volume=47 |issue= 6 |pages= 1118-25 |year= 2005 |pmid= 15168018 |doi= 10.1007/s00125-004-1417-4 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
-}}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
-[[Category:Transport proteins]]
-[[Category:Transmembrane proteins]]
+[[Category:Solute carrier family]]
+{{membrane-protein-stub}}

Latest revision as of 02:56, 28 March 2022

See also[edit]

References[edit]

Further reading[edit]