Chloride potassium symporter 4: Difference between revisions
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Importing Wikidata short description: "Protein-coding gene in the species Homo sapiens" |
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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⚫ | '''Potassium-chloride transporter, member 4''' is a [[chloride potassium symporter]] [[protein]]. It is encoded by the [[gene]] '''SLC12A4'''.<ref name="entrez">{{cite web | title = Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6560}}</ref> |
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{{GNF_Protein_box |
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==See also== |
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| image = |
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* [[Solute carrier family]] |
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| image_source = |
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| PDB = |
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| Name = Solute carrier family 12 (potassium/chloride transporters), member 4 |
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| HGNCid = 10913 |
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| Symbol = SLC12A4 |
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| AltSymbols =; FLJ40489; KCC1 |
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| OMIM = 604119 |
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| ECnumber = |
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| Homologene = 21056 |
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| MGIid = 1309465 |
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| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015379 |text = potassium:chloride symporter activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}} |
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| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} |
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| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006821 |text = chloride transport}} {{GNF_GO|id=GO:0006873 |text = cell ion homeostasis}} {{GNF_GO|id=GO:0006884 |text = regulation of cell volume}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} |
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| Orthologs = {{GNF_Ortholog_box |
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| Hs_EntrezGene = 6560 |
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| Hs_Ensembl = |
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| Hs_RefseqProtein = NP_005063 |
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| Hs_RefseqmRNA = NM_005072 |
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| Hs_GenLoc_db = |
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| Hs_GenLoc_chr = |
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| Hs_GenLoc_start = |
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| Hs_GenLoc_end = |
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| Hs_Uniprot = |
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| Mm_EntrezGene = 20498 |
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| Mm_Ensembl = ENSMUSG00000017765 |
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| Mm_RefseqmRNA = NM_009195 |
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| Mm_RefseqProtein = NP_033221 |
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| Mm_GenLoc_db = |
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| Mm_GenLoc_chr = 8 |
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| Mm_GenLoc_start = 108832721 |
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| Mm_GenLoc_end = 108855173 |
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| Mm_Uniprot = Q3TJG5 |
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}} |
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}} |
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⚫ | Potassium-chloride transporter, member 4''' is a [[chloride potassium symporter]]. It is encoded by the gene '''SLC12A4'''.<ref name="entrez">{{cite web | title = Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4| url = |
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==References== |
==References== |
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==Further reading== |
==Further reading== |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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*{{cite journal | vauthors=Larsen F, Solheim J, Kristensen T |title=A tight cluster of five unrelated human genes on chromosome 16q22.1. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1589–95 |year= 1994 |pmid= 8268911 |doi=10.1093/hmg/2.10.1589 |display-authors=etal}} |
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{{PBB_Further_reading |
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*{{cite journal | vauthors=Gillen CM, Brill S, Payne JA, Forbush B |title=Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. |journal=J. Biol. Chem. |volume=271 |issue= 27 |pages= 16237–44 |year= 1996 |pmid= 8663127 |doi=10.1074/jbc.271.27.16237 |doi-access=free }} |
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| citations = |
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*{{cite journal | |
*{{cite journal | vauthors=Pellegrino CM, Rybicki AC, Musto S |title=Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells. |journal=Blood Cells Mol. Dis. |volume=24 |issue= 1 |pages= 31–40 |year= 1998 |pmid= 9516379 |doi= 10.1006/bcmd.1998.0168 |display-authors=etal}} |
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*{{cite journal | |
*{{cite journal | vauthors=Su W, Shmukler BE, Chernova MN |title=Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. |journal=Am. J. Physiol. |volume=277 |issue= 5 Pt 1 |pages= C899–912 |year= 1999 |pmid= 10564083 |doi= 10.1152/ajpcell.1999.277.5.C899|display-authors=etal}} |
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*{{cite journal | |
*{{cite journal | vauthors=Casula S, Shmukler BE, Wilhelm S |title=A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41870–8 |year= 2001 |pmid= 11551954 |doi= 10.1074/jbc.M107155200 |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Bräuer M, Frei E, Claes L |title=Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl<sup>−</sup> channels in human osteoblasts |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 1 |pages= C22–30 |year= 2003 |pmid= 12637262 |doi= 10.1152/ajpcell.00289.2002 |display-authors=etal}} |
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*{{cite journal | |
*{{cite journal | vauthors=Shen MR, Chou CY, Hsu KF |title=KCl cotransport is an important modulator of human cervical cancer growth and invasion |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 39941–50 |year= 2003 |pmid= 12902337 |doi= 10.1074/jbc.M308232200 |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Zhou GP, Wong C, Su R |title=Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element |journal=Blood |volume=103 |issue= 11 |pages= 4302–9 |year= 2004 |pmid= 14976052 |doi= 10.1182/blood-2003-01-0107 |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Khan AI, Drew C, Ball SE |title=Oxygen dependence of K<sup>+</sup>–Cl<sup>−</sup> cotransport in human red cell ghosts and sickle cells |journal= Bioelectrochemistry|volume=62 |issue= 2 |pages= 141–6 |year= 2005 |pmid= 15039017 |doi= 10.1016/j.bioelechem.2003.07.005 |display-authors=etal}} |
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*{{cite journal | |
*{{cite journal | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}} |
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*{{cite journal | |
*{{cite journal | vauthors=Shen MR, Lin AC, Hsu YM |title=Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40017–25 |year= 2004 |pmid= 15262997 |doi= 10.1074/jbc.M406706200 |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} |
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*{{cite journal | author=Shen MR, Lin AC, Hsu YM, ''et al.'' |title=Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40017-25 |year= 2004 |pmid= 15262997 |doi= 10.1074/jbc.M406706200 }} |
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*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }} |
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}} |
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{{refend}} |
{{refend}} |
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⚫ | |||
{{ion pumps}} |
{{ion pumps}} |
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{{Membrane transport proteins|g2}} |
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[[Category:Solute carrier family]] |
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⚫ |
Latest revision as of 18:17, 28 October 2022
SLC12A4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | SLC12A4, KCC1, Chloride potassium symporter 4, CTC-479C5.17, hKCC1, solute carrier family 12 member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604119; MGI: 1309465; HomoloGene: 21056; GeneCards: SLC12A4; OMA:SLC12A4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.[5]
See also[edit]
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000124067 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017765 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4".
Further reading[edit]
- Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum. Mol. Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
- Gillen CM, Brill S, Payne JA, Forbush B (1996). "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family". J. Biol. Chem. 271 (27): 16237–44. doi:10.1074/jbc.271.27.16237. PMID 8663127.
- Pellegrino CM, Rybicki AC, Musto S, et al. (1998). "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells". Blood Cells Mol. Dis. 24 (1): 31–40. doi:10.1006/bcmd.1998.0168. PMID 9516379.
- Su W, Shmukler BE, Chernova MN, et al. (1999). "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation". Am. J. Physiol. 277 (5 Pt 1): C899–912. doi:10.1152/ajpcell.1999.277.5.C899. PMID 10564083.
- Casula S, Shmukler BE, Wilhelm S, et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity". J. Biol. Chem. 276 (45): 41870–8. doi:10.1074/jbc.M107155200. PMID 11551954.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl− channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
- Shen MR, Chou CY, Hsu KF, et al. (2003). "KCl cotransport is an important modulator of human cervical cancer growth and invasion". J. Biol. Chem. 278 (41): 39941–50. doi:10.1074/jbc.M308232200. PMID 12902337.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Zhou GP, Wong C, Su R, et al. (2004). "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element". Blood. 103 (11): 4302–9. doi:10.1182/blood-2003-01-0107. PMID 14976052.
- Khan AI, Drew C, Ball SE, et al. (2005). "Oxygen dependence of K+–Cl− cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry. 62 (2): 141–6. doi:10.1016/j.bioelechem.2003.07.005. PMID 15039017.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.