Chloride potassium symporter 4: Difference between revisions

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Importing Wikidata short description: "Protein-coding gene in the species Homo sapiens"
 
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox_gene}}
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'''Potassium-chloride transporter, member 4''' is a [[chloride potassium symporter]] [[protein]]. It is encoded by the [[gene]] '''SLC12A4'''.<ref name="entrez">{{cite web | title = Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6560}}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 12 (potassium/chloride transporters), member 4
| HGNCid = 10913
| Symbol = SLC12A4
| AltSymbols =; FLJ40489; KCC1
| OMIM = 604119
| ECnumber =
| Homologene = 21056
| MGIid = 1309465
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015379 |text = potassium:chloride symporter activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006821 |text = chloride transport}} {{GNF_GO|id=GO:0006873 |text = cell ion homeostasis}} {{GNF_GO|id=GO:0006884 |text = regulation of cell volume}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6560
| Hs_Ensembl =
| Hs_RefseqProtein = NP_005063
| Hs_RefseqmRNA = NM_005072
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 20498
| Mm_Ensembl = ENSMUSG00000017765
| Mm_RefseqmRNA = NM_009195
| Mm_RefseqProtein = NP_033221
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 108832721
| Mm_GenLoc_end = 108855173
| Mm_Uniprot = Q3TJG5
}}
}}


==See also==
'''Potassium-chloride transporter, member 4''' is a [[chloride potassium symporter]]. It is encoded by the gene '''SLC12A4'''.<ref name="entrez">{{cite web | title = Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6560| accessdate = }}</ref>
* [[Solute carrier family]]


==References==
==References==
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==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | vauthors=Larsen F, Solheim J, Kristensen T |title=A tight cluster of five unrelated human genes on chromosome 16q22.1. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1589–95 |year= 1994 |pmid= 8268911 |doi=10.1093/hmg/2.10.1589 |display-authors=etal}}
{{PBB_Further_reading
*{{cite journal | vauthors=Gillen CM, Brill S, Payne JA, Forbush B |title=Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. |journal=J. Biol. Chem. |volume=271 |issue= 27 |pages= 16237–44 |year= 1996 |pmid= 8663127 |doi=10.1074/jbc.271.27.16237 |doi-access=free }}
| citations =
*{{cite journal | author=Larsen F, Solheim J, Kristensen T, ''et al.'' |title=A tight cluster of five unrelated human genes on chromosome 16q22.1. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1589-95 |year= 1994 |pmid= 8268911 |doi= }}
*{{cite journal | vauthors=Pellegrino CM, Rybicki AC, Musto S |title=Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells. |journal=Blood Cells Mol. Dis. |volume=24 |issue= 1 |pages= 31–40 |year= 1998 |pmid= 9516379 |doi= 10.1006/bcmd.1998.0168 |display-authors=etal}}
*{{cite journal | author=Gillen CM, Brill S, Payne JA, Forbush B |title=Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. |journal=J. Biol. Chem. |volume=271 |issue= 27 |pages= 16237-44 |year= 1996 |pmid= 8663127 |doi= }}
*{{cite journal | vauthors=Su W, Shmukler BE, Chernova MN |title=Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. |journal=Am. J. Physiol. |volume=277 |issue= 5 Pt 1 |pages= C899–912 |year= 1999 |pmid= 10564083 |doi= 10.1152/ajpcell.1999.277.5.C899|display-authors=etal}}
*{{cite journal | author=Pellegrino CM, Rybicki AC, Musto S, ''et al.'' |title=Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells. |journal=Blood Cells Mol. Dis. |volume=24 |issue= 1 |pages= 31-40 |year= 1998 |pmid= 9516379 |doi= 10.1006/bcmd.1998.0168 }}
*{{cite journal | vauthors=Casula S, Shmukler BE, Wilhelm S |title=A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41870–8 |year= 2001 |pmid= 11551954 |doi= 10.1074/jbc.M107155200 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Su W, Shmukler BE, Chernova MN, ''et al.'' |title=Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. |journal=Am. J. Physiol. |volume=277 |issue= 5 Pt 1 |pages= C899-912 |year= 1999 |pmid= 10564083 |doi= }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal | author=Casula S, Shmukler BE, Wilhelm S, ''et al.'' |title=A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41870-8 |year= 2001 |pmid= 11551954 |doi= 10.1074/jbc.M107155200 }}
*{{cite journal | vauthors=Bräuer M, Frei E, Claes L |title=Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl<sup>−</sup> channels in human osteoblasts |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 1 |pages= C22–30 |year= 2003 |pmid= 12637262 |doi= 10.1152/ajpcell.00289.2002 |display-authors=etal}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors=Shen MR, Chou CY, Hsu KF |title=KCl cotransport is an important modulator of human cervical cancer growth and invasion |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 39941–50 |year= 2003 |pmid= 12902337 |doi= 10.1074/jbc.M308232200 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Bräuer M, Frei E, Claes L, ''et al.'' |title=Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts. |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 1 |pages= C22-30 |year= 2003 |pmid= 12637262 |doi= 10.1152/ajpcell.00289.2002 }}
*{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Shen MR, Chou CY, Hsu KF, ''et al.'' |title=KCl cotransport is an important modulator of human cervical cancer growth and invasion. |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 39941-50 |year= 2003 |pmid= 12902337 |doi= 10.1074/jbc.M308232200 }}
*{{cite journal | vauthors=Zhou GP, Wong C, Su R |title=Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element |journal=Blood |volume=103 |issue= 11 |pages= 4302–9 |year= 2004 |pmid= 14976052 |doi= 10.1182/blood-2003-01-0107 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | vauthors=Khan AI, Drew C, Ball SE |title=Oxygen dependence of K<sup>+</sup>–Cl<sup>−</sup> cotransport in human red cell ghosts and sickle cells |journal= Bioelectrochemistry|volume=62 |issue= 2 |pages= 141–6 |year= 2005 |pmid= 15039017 |doi= 10.1016/j.bioelechem.2003.07.005 |display-authors=etal}}
*{{cite journal | author=Zhou GP, Wong C, Su R, ''et al.'' |title=Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element. |journal=Blood |volume=103 |issue= 11 |pages= 4302-9 |year= 2004 |pmid= 14976052 |doi= 10.1182/blood-2003-01-0107 }}
*{{cite journal | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}}
*{{cite journal | author=Khan AI, Drew C, Ball SE, ''et al.'' |title=Oxygen dependence of K(+)-Cl- cotransport in human red cell ghosts and sickle cells. |journal=Bioelectrochemistry (Amsterdam, Netherlands) |volume=62 |issue= 2 |pages= 141-6 |year= 2005 |pmid= 15039017 |doi= 10.1016/j.bioelechem.2003.07.005 }}
*{{cite journal | vauthors=Shen MR, Lin AC, Hsu YM |title=Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40017–25 |year= 2004 |pmid= 15262997 |doi= 10.1074/jbc.M406706200 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Shen MR, Lin AC, Hsu YM, ''et al.'' |title=Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40017-25 |year= 2004 |pmid= 15262997 |doi= 10.1074/jbc.M406706200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{ion pumps}}
{{ion pumps}}
{{Membrane transport proteins|g2}}

[[Category:Solute carrier family]]


{{membrane-protein-stub}}

Latest revision as of 18:17, 28 October 2022

SLC12A4
Identifiers
AliasesSLC12A4, KCC1, Chloride potassium symporter 4, CTC-479C5.17, hKCC1, solute carrier family 12 member 4
External IDsOMIM: 604119; MGI: 1309465; HomoloGene: 21056; GeneCards: SLC12A4; OMA:SLC12A4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005072
NM_001145961
NM_001145962
NM_001145963
NM_001145964

NM_001253804
NM_009195

RefSeq (protein)

NP_001139433
NP_001139434
NP_001139435
NP_001139436
NP_005063

NP_001240733
NP_033221

Location (UCSC)Chr 16: 67.94 – 67.97 MbChr 8: 106.67 – 106.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124067Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017765Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4".

Further reading[edit]