SLC15A2: Difference between revisions

SLC15A2
Identifiers
Aliases	SLC15A2, PEPT2, solute carrier family 15 member 2
External IDs	OMIM: 602339; MGI: 1890457; HomoloGene: 56912; GeneCards: SLC15A2; OMA:SLC15A2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	121,944,188 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,605,324 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; palpebral conjunctiva; ; corpus epididymis; ; parotid gland; ; seminal vesicula; ; trachea; ; urethra; ; entorhinal cortex; ; optic nerve; ; prostate;
	Top expressed in
	conjunctival fornix; ; olfactory epithelium; ; kidney; ; parotid gland; ; seminal vesicula; ; lacrimal gland; ; saccule; ; Paneth cell; ; trachea; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide:proton symporter activity; protein binding; symporter activity; transporter activity; transmembrane transporter activity; oligopeptide transmembrane transporter activity; dipeptide transmembrane transporter activity; peptide transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	protein transport; peptide transport; oligopeptide transport; ion transport; transmembrane transport; transport; dipeptide transmembrane transport; oligopeptide transmembrane transport; proton transmembrane transport; xenobiotic detoxification by transmembrane export across the plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	6565
	57738
	ENSG00000163406
	ENSMUSG00000022899
	Q16348
	Q9ES07
	NM_001145998; NM_021082
	NM_001145899; NM_021301
	NP_001139470; NP_066568
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 22:22, 3 March 2023

Solute carrier family 15 (H+/peptide transporter), member 2, also known as SLC15A2, is a human gene.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163406 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022899 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2".

Further reading[edit]

Liu W, Liang R, Ramamoorthy S, et al. (1995). "Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney". Biochim. Biophys. Acta. 1235 (2): 461–6. doi:10.1016/0005-2736(95)80036-F. PMID 7756356.
Döring F, Martini C, Walter J, Daniel H (2002). "Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function". J. Membr. Biol. 186 (2): 55–62. doi:10.1007/s00232-001-0135-9. PMID 11944083. S2CID 11211548.
Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. S2CID 16195525.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Groneberg DA (2003). "[Expression, localization and functional aspects of the peptide transporter PEPT2 in the normal respiratory tract and in cystic fibrosis]". Pneumologie (Stuttgart, Germany). 57 (2): 104–5. doi:10.1055/s-2003-37158. PMID 12579467.
Terada T, Irie M, Okuda M, Inui K (2004). "Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function". Biochem. Biophys. Res. Commun. 316 (2): 416–20. doi:10.1016/j.bbrc.2004.02.063. PMID 15020234.
Pinsonneault J, Nielsen CU, Sadée W (2005). "Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions". J. Pharmacol. Exp. Ther. 311 (3): 1088–96. doi:10.1124/jpet.104.073098. PMID 15282265. S2CID 12947228.
Bahadduri PM, D'Souza VM, Pinsonneault JK, et al. (2005). "Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium". Am. J. Respir. Cell Mol. Biol. 32 (4): 319–25. doi:10.1165/rcmb.2004-0322OC. PMID 15626774.
Zhang EY, Emerick RM, Pak YA, et al. (2005). "Comparison of human and monkey peptide transporters: PEPT1 and PEPT2". Mol. Pharm. 1 (3): 201–10. doi:10.1021/mp0499712. PMID 15981923.
Noshiro R, Anzai N, Sakata T, et al. (2006). "The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity". Kidney Int. 70 (2): 275–82. doi:10.1038/sj.ki.5001522. PMID 16738539.
Søndergaard H, Bravo S, Nielsen CU, et al. (2008). "Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1". Eur. J. Pharm. Sci. 33 (4): 332–42. doi:10.1016/j.ejps.2008.01.001. PMID 18295462.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163406 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022899 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2".

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Solute carrier family 15 (H+/peptide transporter), member 2''', also known as '''SLC15A2''', is a [[human]] [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6565}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+==See also==
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+* [[Solute carrier family]]
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 15 (H+/peptide transporter), member 2
- | HGNCid = 10921
- | Symbol = SLC15A2
- | AltSymbols =; PEPT2
- | OMIM = 602339
- | ECnumber =
- | Homologene = 56912
- | MGIid = 1890457
- | GeneAtlas_image1 = PBB_GE_SLC15A2_205317_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SLC15A2_205316_at_tn.png
- | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015198 |text = oligopeptide transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015333 |text = peptide:hydrogen symporter activity}} {{GNF_GO|id=GO:0015334 |text = high affinity oligopeptide transporter activity}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006857 |text = oligopeptide transport}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0015893 |text = drug transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6565
-    | Hs_Ensembl = ENSG00000163406
-    | Hs_RefseqProtein = NP_066568
-    | Hs_RefseqmRNA = NM_021082
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 123095977
-    | Hs_GenLoc_end = 123143147
-    | Hs_Uniprot = Q16348
-    | Mm_EntrezGene = 57738
-    | Mm_Ensembl = ENSMUSG00000022899
-    | Mm_RefseqmRNA = NM_021301
-    | Mm_RefseqProtein = NP_067276
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 16
-    | Mm_GenLoc_start = 36669420
-    | Mm_GenLoc_end = 36704201
-    | Mm_Uniprot = Q80XC0
-  }}
-}}
-'''Solute carrier family 15 (H+/peptide transporter), member 2''', also known as '''SLC15A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6565| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal   |vauthors=Liu W, Liang R, Ramamoorthy S, etal |title=Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. |journal=Biochim. Biophys. Acta |volume=1235 |issue= 2 |pages= 461–6 |year= 1995 |pmid= 7756356 |doi=10.1016/0005-2736(95)80036-F  |doi-access=free }}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Döring F, Martini C, Walter J, Daniel H |title=Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function. |journal=J. Membr. Biol. |volume=186 |issue= 2 |pages= 55–62 |year= 2002 |pmid= 11944083 |doi= 10.1007/s00232-001-0135-9 |s2cid=11211548 }}
-| citations =
-*{{cite journal  | author=Liu W, Liang R, Ramamoorthy S, ''et al.'' |title=Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. |journal=Biochim. Biophys. Acta |volume=1235 |issue= 2 |pages= 461-6 |year= 1995 |pmid= 7756356 |doi=  }}
+*{{cite journal  | vauthors=Alcorn J, Lu X, Moscow JA, McNamara PJ |title=Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. |journal=J. Pharmacol. Exp. Ther. |volume=303 |issue= 2 |pages= 487–96 |year= 2002 |pmid= 12388627 |doi= 10.1124/jpet.102.038315 |s2cid=16195525 }}
-*{{cite journal  | author=Döring F, Martini C, Walter J, Daniel H |title=Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function. |journal=J. Membr. Biol. |volume=186 |issue= 2 |pages= 55-62 |year= 2002 |pmid= 11944083 |doi= 10.1007/s00232-001-0135-9 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Alcorn J, Lu X, Moscow JA, McNamara PJ |title=Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. |journal=J. Pharmacol. Exp. Ther. |volume=303 |issue= 2 |pages= 487-96 |year= 2002 |pmid= 12388627 |doi= 10.1124/jpet.102.038315 }}
+*{{cite journal  | author=Groneberg DA |title=[Expression, localization and functional aspects of the peptide transporter PEPT2 in the normal respiratory tract and in cystic fibrosis] |journal=Pneumologie (Stuttgart, Germany) |volume=57 |issue= 2 |pages= 104–5 |year= 2003 |pmid= 12579467 |doi= 10.1055/s-2003-37158 |doi-access= free }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Terada T, Irie M, Okuda M, Inui K |title=Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 2 |pages= 416–20 |year= 2004 |pmid= 15020234 |doi= 10.1016/j.bbrc.2004.02.063 }}
-*{{cite journal  | author=Groneberg DA |title=[Expression, localization and functional aspects of the peptide transporter PEPT2 in the normal respiratory tract and in cystic fibrosis] |journal=Pneumologie (Stuttgart, Germany) |volume=57 |issue= 2 |pages= 104-5 |year= 2003 |pmid= 12579467 |doi= 10.1055/s-2003-37158 }}
+*{{cite journal  | vauthors=Pinsonneault J, Nielsen CU, Sadée W |title=Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions. |journal=J. Pharmacol. Exp. Ther. |volume=311 |issue= 3 |pages= 1088–96 |year= 2005 |pmid= 15282265 |doi= 10.1124/jpet.104.073098 |s2cid=12947228 }}
-*{{cite journal  | author=Terada T, Irie M, Okuda M, Inui K |title=Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 2 |pages= 416-20 |year= 2004 |pmid= 15020234 |doi= 10.1016/j.bbrc.2004.02.063 }}
+*{{cite journal   |vauthors=Bahadduri PM, D'Souza VM, Pinsonneault JK, etal |title=Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium. |journal=Am. J. Respir. Cell Mol. Biol. |volume=32 |issue= 4 |pages= 319–25 |year= 2005 |pmid= 15626774 |doi= 10.1165/rcmb.2004-0322OC }}
-*{{cite journal  | author=Pinsonneault J, Nielsen CU, Sadée W |title=Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions. |journal=J. Pharmacol. Exp. Ther. |volume=311 |issue= 3 |pages= 1088-96 |year= 2005 |pmid= 15282265 |doi= 10.1124/jpet.104.073098 }}
+*{{cite journal   |vauthors=Zhang EY, Emerick RM, Pak YA, etal |title=Comparison of human and monkey peptide transporters: PEPT1 and PEPT2. |journal=Mol. Pharm. |volume=1 |issue= 3 |pages= 201–10 |year= 2005 |pmid= 15981923 |doi=10.1021/mp0499712  }}
-*{{cite journal  | author=Bahadduri PM, D'Souza VM, Pinsonneault JK, ''et al.'' |title=Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium. |journal=Am. J. Respir. Cell Mol. Biol. |volume=32 |issue= 4 |pages= 319-25 |year= 2005 |pmid= 15626774 |doi= 10.1165/rcmb.2004-0322OC }}
+*{{cite journal   |vauthors=Noshiro R, Anzai N, Sakata T, etal |title=The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity. |journal=Kidney Int. |volume=70 |issue= 2 |pages= 275–82 |year= 2006 |pmid= 16738539 |doi= 10.1038/sj.ki.5001522 |doi-access= free }}
-*{{cite journal  | author=Zhang EY, Emerick RM, Pak YA, ''et al.'' |title=Comparison of human and monkey peptide transporters: PEPT1 and PEPT2. |journal=Mol. Pharm. |volume=1 |issue= 3 |pages= 201-10 |year= 2005 |pmid= 15981923 |doi=  }}
+*{{cite journal   |vauthors=Søndergaard H, Bravo S, Nielsen CU, etal |title=Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1. |journal=Eur. J. Pharm. Sci. |volume=33 |issue= 4 |pages= 332–42 |year= 2008 |pmid= 18295462|doi= 10.1016/j.ejps.2008.01.001 |doi-access= free }}
-*{{cite journal  | author=Noshiro R, Anzai N, Sakata T, ''et al.'' |title=The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity. |journal=Kidney Int. |volume=70 |issue= 2 |pages= 275-82 |year= 2006 |pmid= 16738539 |doi= 10.1038/sj.ki.5001522 }}
-}}
 {{refend}}
+{{Membrane transport proteins}}
-{{protein-stub}}
+[[Category:Solute carrier family]]
+{{membrane-protein-stub}}

Latest revision as of 22:22, 3 March 2023

See also[edit]

References[edit]

Further reading[edit]