Zinc transporter ZIP1: Difference between revisions

SLC39A1
Identifiers
Aliases	SLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDs	OMIM: 604740 MGI: 1353474 HomoloGene: 40906 GeneCards: SLC39A1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,968,184 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,160,919 bp
RNA expression pattern
	Top expressed in
	placenta; ; Achilles tendon; ; upper lobe of left lung; ; right lung; ; stromal cell of endometrium; ; gallbladder; ; right adrenal gland; ; left adrenal gland; ; ascending aorta; ; right coronary artery;
	Top expressed in
	prostate; ; belly cord; ; epidermis; ; lip; ; uterus; ; placenta; ; urinary bladder; ; gallbladder; ; duodenum; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion transmembrane transporter activity; inorganic cation transmembrane transporter activity; zinc ion transmembrane transporter activity; signaling receptor binding;
Cellular component	integral component of membrane; plasma membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	embryonic cranial skeleton morphogenesis; metal ion transport; zinc ion transmembrane transport; cation transport; zinc ion transport; in utero embryonic development; ion transport; limb development; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	27173
	30791
	ENSG00000143570
	ENSMUSG00000052310
	Q9NY26
	Q9QZ03
NM_014437; NM_001271957; NM_001271958; NM_001271959; NM_001271960;
	NM_001271961
	NM_013901
NP_001258886; NP_001258887; NP_001258888; NP_001258889; NP_001258890;
	NP_055252
	NP_038929
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 16:23, 26 November 2023

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.^[5]^[6]^[7]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143570 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052310 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Further reading[edit]

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells". J. Biol. Chem. 276 (25): 22258–64. doi:10.1074/jbc.M101772200. PMID 11301334.
Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID 11696349. S2CID 19962909.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Franklin RB, Ma J, Zou J, et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells". J. Inorg. Biochem. 96 (2–3): 435–42. doi:10.1016/S0162-0134(03)00249-6. PMC 4465841. PMID 12888280.
Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Franklin RB, Feng P, Milon B, et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer. 4: 32. doi:10.1186/1476-4598-4-32. PMC 1243239. PMID 16153295.
Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone. 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID 16203195.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi:10.1111/j.1742-4658.2007.05933.x. PMID 17635580. S2CID 21792127.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143570 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052310 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10610721-5] Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.

[pmid10681536-6] Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.

[entrez-7] "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".

[pmid16700911-8] Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein found in humans}}
 {{Infobox_gene}}
-'''Zinc transporter ZIP1''' is a [[protein]] that in humans is encoded by the ''SLC39A1'' [[gene]].<ref name="pmid10610721">{{cite journal | vauthors = Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J | title = Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex | journal = Genomics | volume = 62 | issue = 2 | pages = 272–80 |date=Feb 2000 | pmid = 10610721 | pmc =  | doi = 10.1006/geno.1999.5993 }}</ref>
+'''Zinc transporter ZIP1''' is a [[protein]] that in humans is encoded by the ''SLC39A1'' [[gene]].<ref name="pmid10610721">{{cite journal | vauthors = Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J | title = Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex | journal = Genomics | volume = 62 | issue = 2 | pages = 272–80 |date=Feb 2000 | pmid = 10610721 | doi = 10.1006/geno.1999.5993 }}</ref><ref name="pmid10681536">{{cite journal | vauthors = Gaither LA, Eide DJ | title = Functional expression of the human hZIP2 zinc transporter | journal = J Biol Chem | volume = 275 | issue = 8 | pages = 5560–4 |date=Mar 2000 | pmid = 10681536 | doi =10.1074/jbc.275.8.5560  | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27173}}</ref>
-<ref name="pmid10681536">{{cite journal | vauthors = Gaither LA, Eide DJ | title = Functional expression of the human hZIP2 zinc transporter | journal = J Biol Chem | volume = 275 | issue = 8 | pages = 5560–4 |date=Mar 2000 | pmid = 10681536 | pmc =  | doi =10.1074/jbc.275.8.5560  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27173| accessdate = }}</ref>
-The protein ZIP1 is responsible for the active transport of [[zinc]] into [[prostate]] cells. In many [[prostate cancer]]s SLC39A1 is silenced causing prostate cancer cells to be low in zinc.<ref name="pmid16700911">{{cite journal | vauthors = Costello LC, Franklin RB | title = The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots | journal = Mol. Cancer | volume = 5 | issue = | pages = 17 | year = 2006 | pmid = 16700911 | pmc = 1481516 | doi = 10.1186/1476-4598-5-17 | url = | issn = }}</ref>
+The protein ZIP1 is responsible for the active transport of [[zinc]] into [[prostate]] cells. In many [[prostate cancer]]s SLC39A1 is silenced causing prostate cancer cells to be low in zinc.<ref name="pmid16700911">{{cite journal | vauthors = Costello LC, Franklin RB | title = The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots | journal = Mol. Cancer | volume = 5 | pages = 17 | year = 2006 | pmid = 16700911 | pmc = 1481516 | doi = 10.1186/1476-4598-5-17 | doi-access = free }}</ref>
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 ==See also==
@@ Line 19: / Line 13: @@
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
 *{{cite journal   |vauthors=Lai CH, Chou CY, Ch'ang LY, etal |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703  | pmc=310876  }}
-*{{cite journal  | vauthors=Gaither LA, Eide DJ |title=The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22258–64 |year= 2001 |pmid= 11301334 |doi= 10.1074/jbc.M101772200 }}
+*{{cite journal  | vauthors=Gaither LA, Eide DJ |title=The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22258–64 |year= 2001 |pmid= 11301334 |doi= 10.1074/jbc.M101772200 |doi-access= free }}
-*{{cite journal   |vauthors=Milon B, Dhermy D, Pountney D, etal |title=Differential subcellular localization of hZip1 in adherent and non-adherent cells. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 241–6 |year= 2001 |pmid= 11696349 |doi=10.1016/S0014-5793(01)02950-7  }}
+*{{cite journal   |vauthors=Milon B, Dhermy D, Pountney D, etal |title=Differential subcellular localization of hZip1 in adherent and non-adherent cells. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 241–6 |year= 2001 |pmid= 11696349 |doi=10.1016/S0014-5793(01)02950-7  |s2cid=19962909 |doi-access= }}
-*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
 *{{cite journal   |vauthors=Franklin RB, Ma J, Zou J, etal |title=Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. |journal=J. Inorg. Biochem. |volume=96 |issue= 2–3 |pages= 435–42 |year= 2003 |pmid= 12888280 |doi=10.1016/S0162-0134(03)00249-6  |pmc=4465841 }}
-*{{cite journal   |vauthors=Dufner-Beattie J, Langmade SJ, Wang F, etal |title=Structure, function, and regulation of a subfamily of mouse zinc transporter genes |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50142–50 |year= 2004 |pmid= 14525987 |doi= 10.1074/jbc.M304163200 }}
+*{{cite journal   |vauthors=Dufner-Beattie J, Langmade SJ, Wang F, etal |title=Structure, function, and regulation of a subfamily of mouse zinc transporter genes |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50142–50 |year= 2004 |pmid= 14525987 |doi= 10.1074/jbc.M304163200 |doi-access= free }}
-*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
 *{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal   |vauthors=Franklin RB, Feng P, Milon B, etal |title=hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer |journal=Mol. Cancer |volume=4 |issue=  |pages= 32 |year= 2006 |pmid= 16153295 |doi= 10.1186/1476-4598-4-32  | pmc=1243239 }}
+*{{cite journal   |vauthors=Franklin RB, Feng P, Milon B, etal |title=hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer |journal=Mol. Cancer |volume=4 |pages= 32 |year= 2006 |pmid= 16153295 |doi= 10.1186/1476-4598-4-32  | pmc=1243239 |doi-access=free }}
 *{{cite journal   |vauthors=Tang Z, Sahu SN, Khadeer MA, etal |title=Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells |journal=Bone |volume=38 |issue= 2 |pages= 181–98 |year= 2006 |pmid= 16203195 |doi= 10.1016/j.bone.2005.08.010 }}
-*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
+*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |doi-access= free }}
-*{{cite journal  | vauthors=Huang L, Kirschke CP |title=A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein |journal=FEBS J. |volume=274 |issue= 15 |pages= 3986–97 |year= 2007 |pmid= 17635580 |doi= 10.1111/j.1742-4658.2007.05933.x }}
+*{{cite journal  | vauthors=Huang L, Kirschke CP |title=A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein |journal=FEBS J. |volume=274 |issue= 15 |pages= 3986–97 |year= 2007 |pmid= 17635580 |doi= 10.1111/j.1742-4658.2007.05933.x |s2cid=21792127 |doi-access=free }}
-}}
 {{refend}}
 {{Membrane transport proteins}}
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 [[Category:Solute carrier family]]

Latest revision as of 16:23, 26 November 2023

See also[edit]

References[edit]

Further reading[edit]