SLC5A4: Difference between revisions

SLC5A4
Identifiers
Aliases	SLC5A4, DJ90G24.4, SAAT1, SGLT3, solute carrier family 5 member 4
External IDs	MGI: 1927848; HomoloGene: 8591; GeneCards: SLC5A4; OMA:SLC5A4 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	32,255,347 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,025,099 bp
RNA expression pattern
	Top expressed in
	duodenum; ; testicle; ; islet of Langerhans; ; smooth muscle tissue; ; upper lobe of left lung; ; body of uterus; ; sural nerve; ; right lung; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	morula; ; jejunum; ; intestinal villus; ; duodenum; ; lumbar subsegment of spinal cord; ; proximal tubule; ; cumulus cell; ; ileum; ; right kidney; ; ovary;
	More reference expression data
	n/a
Gene ontology
Molecular function	glucose:sodium symporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane;
Biological process	ion transport; transmembrane transport; sodium ion transport; glucose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6527
	64452
	ENSG00000100191
	ENSMUSG00000020229
	Q9NY91
	Q9ET37
	NM_014227
	NM_133184
	NP_055042
	NP_573447
	Wikidata
View/Edit Human	View/Edit Mouse

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The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is a protein that in humans is encoded by the SLC5A4 gene.^[5]^[6]^[7] It functions as a sugar sensor.

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100191 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020229 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
^ Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (March 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.
^ Jung H (October 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.

Further reading[edit]

Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression". Neuropsychobiology. 53 (1): 1–8. doi:10.1159/000089915. PMID 16319503. S2CID 12803994.
Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG (2007). "Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis". Behavioral and Brain Functions. 3: 41. doi:10.1186/1744-9081-3-41. PMC 1994953. PMID 17705872.
Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (September 2003). "A glucose sensor hiding in a family of transporters". Proceedings of the National Academy of Sciences of the United States of America. 100 (20): 11753–8. Bibcode:2003PNAS..10011753D. doi:10.1073/pnas.1733027100. PMC 208830. PMID 13130073.
Fairchild TJ (January 2008). "Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?". Journal of Applied Physiology. 104 (1): 315, author reply 316. doi:10.1152/japplphysiol.00793.2007. PMID 18198291. S2CID 29443314.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (February 2007). "Imino sugars are potent agonists of the human glucose sensor SGLT3". Molecular Pharmacology. 71 (2): 628–34. doi:10.1124/mol.106.030288. PMID 17110502. S2CID 13642065.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100191 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020229 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".

[pmid9501190-6] Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (March 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.

[pmid12354616-7] Jung H (October 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.

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Line 1: {{Short description\|Protein-coding gene in the species Homo sapiens}} ~~{{PBB\|geneid=6527}}~~ {{Infobox_gene}} The '''low affinity sodium-glucose cotransporter''' also known as the '''sodium/glucose cotransporter 3''' (SGLT3) or '''solute carrier family 5 member 4''' (SLC5A4) is a [[protein]] that in humans is encoded by the ''SLC5A4'' [[gene]].<ref name="entrez">{{cite web \| title = Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)\| url = ~~http~~https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6527~~\| accessdate =~~ }}</ref><ref name="pmid9501190">{{cite journal \| ~~author~~vauthors = Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H \| title = Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1 \| journal = ~~Proc.~~Proceedings ~~Natl.~~of ~~Acad.~~the ~~Sci.~~National ~~U.S.A.~~Academy of Sciences of the United States of America \| volume = 95 \| issue = 6 \| pages = 2914–9 \| ~~year~~date = March 1998 ~~\| month = March~~ \| pmid = 9501190 \| pmc = 19669 \| doi = 10.1073/pnas.95.6.2914 \| ~~url~~bibcode = 1998PNAS...95.2914V \| ~~issn~~doi-access = free }}</ref><ref name="pmid12354616">{{cite journal \| ~~author~~vauthors = Jung H \| title = The sodium/substrate symporter family: structural and functional features \| journal = FEBS ~~Lett.~~Letters \| volume = 529 \| issue = 1 \| pages = 73–7 \| ~~year~~date = October 2002 ~~\| month = October~~ \| pmid = 12354616 \| doi = ~~\| url =~~10.1016/S0014-5793(02)03184-8 \| ~~issn~~doi-access = free }}</ref> It functions as a sugar sensor. == References == {{reflist}} == Further reading == {{refbegin \| 2}} * {{cite journal \| ~~author~~vauthors = Munafò MR, Clark TG, Roberts KH, Johnstone EC \| title = Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression \| journal = Neuropsychobiology \| volume = 53 \| issue = 1 \| pages = 1–8 \| year = 2006 \| pmid = 16319503 \| doi = 10.1159/000089915 \| ~~url~~s2cid = ~~\| issn =~~12803994 }} * {{cite journal \|~~author~~ vauthors = Blaya C, Salum GA, Lima MS, ~~''et~~Leistner-Segal ~~al.''~~S, Manfro GG \| title = Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis. \| journal = Behavioral and Brain Functions \| volume=3 ~~\|issue~~= 3 \| pages = 41 \| year = 2007 \| pmid = 17705872 \| pmc = 1994953 \| doi = 10.1186/1744-9081-3-41 \| doi-access = free }} * {{cite journal \|~~author~~ vauthors = Diez-Sampedro A, Hirayama BA, Osswald C, ~~''et~~Gorboulev ~~al.''~~V, Baumgarten K, Volk C, Wright EM, Koepsell H \| title = A glucose sensor hiding in a family of transporters. \| journal =~~Proc.~~ ~~Natl.~~Proceedings ~~Acad.~~of ~~Sci.~~the ~~U.S.A.~~National Academy of Sciences of the United States of America \| volume = 100 \| issue = 20 \| pages = 11753–8 \|~~year~~ date = September 2003 \| pmid = 13130073 \| pmc = 208830 \| doi = 10.1073/pnas.1733027100 \| bibcode = 2003PNAS..10011753D \| doi-access = free }} * {{cite journal \|~~author~~ vauthors = Fairchild TJ \| title = Protection of muscle membrane excitability during cycling in humans: a role for SGLT3? \| journal =J. ~~Appl.~~Journal ~~Physiol.~~of Applied Physiology \| volume = 104 \| issue = 1 \| pages = 315; author reply 316 \|~~year~~ date = January 2008 \| pmid = 18198291 \| doi = 10.1152/japplphysiol.00793.2007 \| s2cid = 29443314 }} * {{cite journal \|~~author~~ vauthors = Dunham I, Shimizu N, Roe BA, ~~''et~~Chissoe ~~al.'~~S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP \| title = The DNA sequence of human chromosome 22. \| journal = Nature \| volume = 402 \| issue = 6761 \| pages = 489–95 \|~~year~~ date = December 1999 \| pmid = 10591208 \| doi = 10.1038/990031 \| bibcode = 1999Natur.402..489D \| doi-access = free }} * {{cite journal \| ~~author~~vauthors = Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM \| title = Imino sugars are potent agonists of the human glucose sensor SGLT3 \| journal = ~~Mol.~~Molecular ~~Pharmacol.~~Pharmacology \| volume = 71 \| issue = 2 \| pages = 628–34 \| ~~year~~date = February 2007 ~~\| month = February~~ \| pmid = 17110502 \| doi = 10.1124/mol.106.030288 \| ~~url~~s2cid = ~~\| issn =~~13642065 }} {{refend}} {{Solute carrier family\|bg\|bg0}} ~~{{Membrane transport proteins}}~~ [[Category:Solute carrier family]]