Asc-type amino acid transporter 1: Difference between revisions

SLC7A10
Identifiers
Aliases	SLC7A10, HASC-1, asc-1, ASC1, solute carrier family 7 member 10
External IDs	OMIM: 607959; MGI: 1858261; HomoloGene: 56767; GeneCards: SLC7A10; OMA:SLC7A10 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	33,225,850 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	34,900,539 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; amygdala; ; subcutaneous adipose tissue; ; hypothalamus; ; substantia nigra; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; prefrontal cortex;
	Top expressed in
	medial vestibular nucleus; ; white adipose tissue; ; mammillary body; ; dorsal tegmental nucleus; ; subcutaneous adipose tissue; ; inferior colliculus; ; ventromedial nucleus; ; retinal pigment epithelium; ; globus pallidus; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	antiporter activity; L-serine transmembrane transporter activity; neutral amino acid transmembrane transporter activity; transmembrane transporter activity; L-amino acid transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	leukocyte migration; neutral amino acid transport; D-alanine transport; amino acid transport; D-serine transport; L-serine transport; transmembrane transport; L-alpha-amino acid transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	56301
	53896
	ENSG00000130876
	ENSMUSG00000030495
	Q9NS82
	P63115
	NM_019849
	NM_017394
	NP_062823
	NP_059090
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 12:55, 18 January 2024

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.^[5]^[6]^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130876 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030495 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 10".
^ Fukasawa Y, Segawa H, Kim JY, Chairoungdua A, Kim DK, Matsuo H, Cha SH, Endou H, Kanai Y (March 2000). "Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids". J. Biol. Chem. 275 (13): 9690–8. doi:10.1074/jbc.275.13.9690. PMID 10734121.
^ Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, Cha SH, Inatomi J, Shiokawa Y, Yamaguchi K, Saito I, Endou H, Kanai Y (June 2000). "Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity". Neurosci. Lett. 287 (3): 231–5. doi:10.1016/S0304-3940(00)01169-1. PMID 10863037. S2CID 23904731.

Further reading[edit]

Leclerc D, Wu Q, Ellis JR, et al. (2001). "Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?". Mol. Genet. Metab. 73 (4): 333–9. doi:10.1006/mgme.2001.3209. PMID 11509015.
Imielinski M, Baldassano RN, Griffiths A, et al. (2009). "Common variants at five new loci associated with early-onset inflammatory bowel disease". Nat. Genet. 41 (12): 1335–40. doi:10.1038/ng.489. PMC 3267927. PMID 19915574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pineda M, Font M, Bassi MT, et al. (2004). "The amino acid transporter asc-1 is not involved in cystinuria". Kidney Int. 66 (4): 1453–64. doi:10.1111/j.1523-1755.2004.00908.x. PMID 15458438.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
Bröer S (January 2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
Xu D, Hemler ME (2005). "Metabolic activation-related CD147-CD98 complex". Mol. Cell. Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130876 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030495 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 10".

[pmid10734121-6] Fukasawa Y, Segawa H, Kim JY, Chairoungdua A, Kim DK, Matsuo H, Cha SH, Endou H, Kanai Y (March 2000). "Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids". J. Biol. Chem. 275 (13): 9690–8. doi:10.1074/jbc.275.13.9690. PMID 10734121.

[pmid10863037-7] Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, Cha SH, Inatomi J, Shiokawa Y, Yamaguchi K, Saito I, Endou H, Kanai Y (June 2000). "Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity". Neurosci. Lett. 287 (3): 231–5. doi:10.1016/S0304-3940(00)01169-1. PMID 10863037. S2CID 23904731.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=56301}}
+{{cs1 config|name-list-style=vanc}}
-'''Solute carrier family 7 member 10''' also known as '''Asc-type amino acid transporter 1''' or '''Asc-1''' is a [[protein]] that in humans is encoded by the ''SLC7A10'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 10 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56301| accessdate = }}</ref><ref name="pmid10734121">{{cite journal | author = Fukasawa Y, Segawa H, Kim JY, Chairoungdua A, Kim DK, Matsuo H, Cha SH, Endou H, Kanai Y | title = Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids | journal = J. Biol. Chem. | volume = 275 | issue = 13 | pages = 9690–8 | year = 2000 | month = March | pmid = 10734121 | doi = | url = | issn = }}</ref><ref name="pmid10863037">{{cite journal | author = Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, Cha SH, Inatomi J, Shiokawa Y, Yamaguchi K, Saito I, Endou H, Kanai Y | title = Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity | journal = Neurosci. Lett. | volume = 287 | issue = 3 | pages = 231–5 | year = 2000 | month = June | pmid = 10863037 | doi = | url = | issn = }}</ref>
+{{Infobox_gene}}
+'''Asc-type amino acid transporter 1''' ('''Asc-1''') is a [[protein]] that in humans is encoded by the ''SLC7A10'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 10 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56301}}</ref><ref name="pmid10734121">{{cite journal |author1=Fukasawa Y |author2=Segawa H |author3=Kim JY |author4=Chairoungdua A |author5=Kim DK |author6=Matsuo H |author7=Cha SH |author8=Endou H |author9=Kanai Y | title = Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids | journal = J. Biol. Chem. | volume = 275 | issue = 13 | pages = 9690–8 |date=March 2000 | pmid = 10734121 | doi = 10.1074/jbc.275.13.9690|doi-access=free }}</ref><ref name="pmid10863037">{{cite journal |author1=Nakauchi J |author2=Matsuo H |author3=Kim DK |author4=Goto A |author5=Chairoungdua A |author6=Cha SH |author7=Inatomi J |author8=Shiokawa Y |author9=Yamaguchi K |author10=Saito I |author11=Endou H |author12=Kanai Y | title = Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity | journal = Neurosci. Lett. | volume = 287 | issue = 3 | pages = 231–5 |date=June 2000 | pmid = 10863037 | doi = 10.1016/S0304-3940(00)01169-1|s2cid=23904731 }}</ref>
+==See also==
+* [[Heterodimeric amino acid transporter]]
 ==References==
@@ Line 7: / Line 12: @@
 ==Further reading==
 {{refbegin | 2}}
-*{{cite journal  |author=Leclerc D, Wu Q, Ellis JR, ''et al.'' |title=Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria? |journal=Mol. Genet. Metab. |volume=73 |issue= 4 |pages= 333-9 |year= 2001 |pmid= 11509015 |doi= 10.1006/mgme.2001.3209 }}
+*{{cite journal   |vauthors=Leclerc D, Wu Q, Ellis JR, etal |title=Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria? |journal=Mol. Genet. Metab. |volume=73 |issue= 4 |pages= 333–9 |year= 2001 |pmid= 11509015 |doi= 10.1006/mgme.2001.3209 }}
-*{{cite journal  |author=Imielinski M, Baldassano RN, Griffiths A, ''et al.'' |title=Common variants at five new loci associated with early-onset inflammatory bowel disease. |journal=Nat. Genet. |volume=41 |issue= 12 |pages= 1335-40 |year= 2009 |pmid= 19915574 |doi= 10.1038/ng.489 }}
+*{{cite journal   |vauthors=Imielinski M, Baldassano RN, Griffiths A, etal |title=Common variants at five new loci associated with early-onset inflammatory bowel disease. |journal=Nat. Genet. |volume=41 |issue= 12 |pages= 1335–40 |year= 2009 |pmid= 19915574 |doi= 10.1038/ng.489 |pmc=3267927}}
-*{{cite journal  |author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
-*{{cite journal  |author=Pineda M, Font M, Bassi MT, ''et al.'' |title=The amino acid transporter asc-1 is not involved in cystinuria. |journal=Kidney Int. |volume=66 |issue= 4 |pages= 1453-64 |year= 2004 |pmid= 15458438 |doi= 10.1111/j.1523-1755.2004.00908.x }}
+*{{cite journal   |vauthors=Pineda M, Font M, Bassi MT, etal |title=The amino acid transporter asc-1 is not involved in cystinuria. |journal=Kidney Int. |volume=66 |issue= 4 |pages= 1453–64 |year= 2004 |pmid= 15458438 |doi= 10.1111/j.1523-1755.2004.00908.x |doi-access= free }}
-*{{cite journal  |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  |author=Dehal P, Predki P, Olsen AS, ''et al.'' |title=Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. |journal=Science |volume=293 |issue= 5527 |pages= 104-11 |year= 2001 |pmid= 11441184 |doi= 10.1126/science.1060310 }}
+*{{cite journal   |vauthors=Dehal P, Predki P, Olsen AS, etal |title=Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. |journal=Science |volume=293 |issue= 5527 |pages= 104–11 |year= 2001 |pmid= 11441184 |doi= 10.1126/science.1060310 |s2cid=826987 }}
-*{{cite journal | author = Bröer S | title = Amino acid transport across mammalian intestinal and renal epithelia | journal = Physiol. Rev. | volume = 88 | issue = 1 | pages = 249–86 | year = 2008 | month = January | pmid = 18195088 | doi = 10.1152/physrev.00018.2006 | url = | issn = }}
+*{{cite journal | author = Bröer S | title = Amino acid transport across mammalian intestinal and renal epithelia | journal = Physiol. Rev. | volume = 88 | issue = 1 | pages = 249–86 |date=January 2008 | pmid = 18195088 | doi = 10.1152/physrev.00018.2006 }}
-*{{cite journal  |author=Xu D, Hemler ME |title=Metabolic activation-related CD147-CD98 complex. |journal=Mol. Cell Proteomics |volume=4 |issue= 8 |pages= 1061-71 |year= 2005 |pmid= 15901826 |doi= 10.1074/mcp.M400207-MCP200 }}
+*{{cite journal  |author1=Xu D |author2=Hemler ME |title=Metabolic activation-related CD147-CD98 complex. |journal=Mol. Cell. Proteomics |volume=4 |issue= 8 |pages= 1061–71 |year= 2005 |pmid= 15901826 |doi= 10.1074/mcp.M400207-MCP200 |doi-access=free |pmc=1351277}}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
 [[Category:Solute carrier family]]
+{{membrane-protein-stub}}

Latest revision as of 12:55, 18 January 2024

See also[edit]

References[edit]

Further reading[edit]