RHCG: Difference between revisions
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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category) |
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
{{Infobox_gene}} |
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'''Rh family, C glycoprotein''', also known as '''RHCG''', is a [[protein]] that in humans is encoded by the ''RHCG'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RHCG Rh family, C glycoprotein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51458}}</ref><ref name="pmid10852913">{{cite journal | vauthors = Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH | title = Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25641–51 |date=August 2000 | pmid = 10852913 | doi = 10.1074/jbc.M003353200 | doi-access = free }}</ref> |
'''Rh family, C glycoprotein''', also known as '''RHCG''', is a [[protein]] that in humans is encoded by the ''RHCG'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RHCG Rh family, C glycoprotein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51458}}</ref><ref name="pmid10852913">{{cite journal | vauthors = Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH | title = Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25641–51 |date=August 2000 | pmid = 10852913 | doi = 10.1074/jbc.M003353200 | doi-access = free }}</ref> |
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== Function == |
== Function == |
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RHCG plays a critical role in [[ammonium]] handling and pH [[homeostasis]] in the kidney.<ref name="pmid19020613">{{cite journal | vauthors = Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM | title = A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility | journal = Nature | volume = 456 | issue = 7220 | pages = 339–43 |date=November 2008 | pmid = 19020613 | doi = 10.1038/nature07518 | bibcode = 2008Natur.456..339B | s2cid = 205215412 }}</ref> The structure of the RHCG protein<ref name="pmid20457942">{{PDB|3hd6}}; {{cite journal | vauthors = Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM | title = Function of human Rh based on structure of RhCG at 2.1 A | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 107 | issue = 21 | pages = 9638–43 |date=May 2010 | pmid = 20457942 | pmc = 2906887 | doi = 10.1073/pnas.1003587107 | doi-access = free }}</ref> indicates that it has a hydrophobic [[ammonia]]-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an [[ammonia transporter]]. |
RHCG plays a critical role in [[ammonium]] handling and pH [[homeostasis]] in the kidney.<ref name="pmid19020613">{{cite journal | vauthors = Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM | title = A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility | journal = Nature | volume = 456 | issue = 7220 | pages = 339–43 |date=November 2008 | pmid = 19020613 | doi = 10.1038/nature07518 | bibcode = 2008Natur.456..339B | s2cid = 205215412 }}</ref> The structure of the RHCG protein<ref name="pmid20457942">{{PDB|3hd6}}; {{cite journal | vauthors = Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM | title = Function of human Rh based on structure of RhCG at 2.1 A | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 107 | issue = 21 | pages = 9638–43 |date=May 2010 | pmid = 20457942 | pmc = 2906887 | doi = 10.1073/pnas.1003587107 | doi-access = free | bibcode = 2010PNAS..107.9638G }}</ref> indicates that it has a hydrophobic [[ammonia]]-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an [[ammonia transporter]]. |
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==References== |
==References== |
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*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} |
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} |
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*{{cite journal |vauthors=Nicolas V, Le Van Kim C, Gane P, etal |title=Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25526–33 |year= 2003 |pmid= 12719424 |doi= 10.1074/jbc.M302816200 |doi-access= free }} |
*{{cite journal |vauthors=Nicolas V, Le Van Kim C, Gane P, etal |title=Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25526–33 |year= 2003 |pmid= 12719424 |doi= 10.1074/jbc.M302816200 |doi-access= free }} |
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*{{cite journal |vauthors=Hemker MB, Cheroutre G, van Zwieten R, etal |title=The Rh complex exports ammonium from human red blood cells. |journal=Br. J. Haematol. |volume=122 |issue= 2 |pages= 333–40 |year= 2003 |pmid= 12846905 |doi=10.1046/j.1365-2141.2003.04425.x |s2cid=3094213 }} |
*{{cite journal |vauthors=Hemker MB, Cheroutre G, van Zwieten R, etal |title=The Rh complex exports ammonium from human red blood cells. |journal=Br. J. Haematol. |volume=122 |issue= 2 |pages= 333–40 |year= 2003 |pmid= 12846905 |doi=10.1046/j.1365-2141.2003.04425.x |s2cid=3094213 |doi-access=free }} |
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*{{cite journal |vauthors=Bakouh N, Benjelloun F, Hulin P, etal |title=NH<sub>3</sub> is involved in the NH<sub>4</sub><sup>+</sup> transport induced by the functional expression of the human Rh C glycoprotein. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 15975–83 |year= 2004 |pmid= 14761968 |doi= 10.1074/jbc.M308528200 |doi-access= free }} |
*{{cite journal |vauthors=Bakouh N, Benjelloun F, Hulin P, etal |title=NH<sub>3</sub> is involved in the NH<sub>4</sub><sup>+</sup> transport induced by the functional expression of the human Rh C glycoprotein. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 15975–83 |year= 2004 |pmid= 14761968 |doi= 10.1074/jbc.M308528200 |doi-access= free }} |
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*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} |
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} |
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Latest revision as of 15:20, 11 April 2024
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RHCG, C15orf6, PDRC2, RHGK, SLC42A3, Rh family C glycoprotein | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605381; MGI: 1888517; HomoloGene: 32310; GeneCards: RHCG; OMA:RHCG - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene.[5][6]
Function[edit]
RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.[7] The structure of the RHCG protein[8] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000140519 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030549 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: RHCG Rh family, C glycoprotein".
- ^ Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (August 2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.
- ^ Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (November 2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature. 456 (7220): 339–43. Bibcode:2008Natur.456..339B. doi:10.1038/nature07518. PMID 19020613. S2CID 205215412.
- ^ PDB: 3hd6; Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM (May 2010). "Function of human Rh based on structure of RhCG at 2.1 A". Proc. Natl. Acad. Sci. U.S.A. 107 (21): 9638–43. Bibcode:2010PNAS..107.9638G. doi:10.1073/pnas.1003587107. PMC 2906887. PMID 20457942.
Further reading[edit]
- Bakouh N, Benjelloun F, Cherif-Zahar B, Planelles G (2006). "The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins". Transfusion Clinique et Biologique. 13 (1–2): 139–46. doi:10.1016/j.tracli.2006.02.008. PMID 16564724.
- Zidi-Yahiaoui N, Ripoche P, Le Van Kim C, et al. (2006). "Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis". Transfusion Clinique et Biologique. 13 (1–2): 128–31. doi:10.1016/j.tracli.2006.02.025. PMID 16580862.
- Ridgwell K, Spurr NK, Laguda B, et al. (1992). "Isolation of cDNA clones for a 50 kDa glycoprotein of the human erythrocyte membrane associated with Rh (rhesus) blood-group antigen expression". Biochem. J. 287 (1): 223–8. doi:10.1042/bj2870223. PMC 1133147. PMID 1417776.
- Liu Z, Chen Y, Mo R, et al. (2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.
- Marini AM, Matassi G, Raynal V, et al. (2000). "The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast". Nat. Genet. 26 (3): 341–4. doi:10.1038/81656. PMID 11062476. S2CID 21313219.
- Chen BS, Xu ZX, Xu X, et al. (2002). "RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia". Eur. J. Cancer. 38 (14): 1927–36. doi:10.1016/S0959-8049(02)00190-9. PMID 12204676.
- Verlander JW, Miller RT, Frank AE, et al. (2003). "Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney". Am. J. Physiol. Renal Physiol. 284 (2): F323–37. doi:10.1152/ajprenal.00050.2002. PMID 12388412.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nicolas V, Le Van Kim C, Gane P, et al. (2003). "Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation". J. Biol. Chem. 278 (28): 25526–33. doi:10.1074/jbc.M302816200. PMID 12719424.
- Hemker MB, Cheroutre G, van Zwieten R, et al. (2003). "The Rh complex exports ammonium from human red blood cells". Br. J. Haematol. 122 (2): 333–40. doi:10.1046/j.1365-2141.2003.04425.x. PMID 12846905. S2CID 3094213.
- Bakouh N, Benjelloun F, Hulin P, et al. (2004). "NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein". J. Biol. Chem. 279 (16): 15975–83. doi:10.1074/jbc.M308528200. PMID 14761968.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, et al. (2006). "Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells". Biochem. J. 391 (Pt 1): 33–40. doi:10.1042/BJ20050657. PMC 1237136. PMID 15929723.
- Huang CH, Peng J (2005). "Evolutionary conservation and diversification of Rh family genes and proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15512–7. Bibcode:2005PNAS..10215512H. doi:10.1073/pnas.0507886102. PMC 1266151. PMID 16227429.
- Marini AM, Boeckstaens M, Benjelloun F, et al. (2006). "Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters". Curr. Genet. 49 (6): 364–74. doi:10.1007/s00294-006-0062-5. PMID 16477434. S2CID 28636156.
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