Zinc transporter ZIP2: Difference between revisions

SLC39A2
Identifiers
Aliases	SLC39A2, 6A1, ETI-1, ZIP-2, ZIP2, solute carrier family 39 member 2
External IDs	OMIM: 612166; MGI: 2684326; HomoloGene: 40957; GeneCards: SLC39A2; OMA:SLC39A2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	21,001,871 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	52,134,202 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; epithelium of esophagus; ; gingival epithelium; ; vulva; ; cervix epithelium; ; skin of arm; ; seminal vesicula; ; vagina; ; palpebral conjunctiva;
	Top expressed in
	cervix; ; lip; ; gastrula; ; decidua; ; vestibular membrane of cochlear duct; ; olfactory epithelium; ; blastocyst; ; morula; ; neural layer of retina; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion transmembrane transporter activity; zinc ion transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cytoplasmic vesicle;
Biological process	metal ion transport; zinc ion transport; ion transport; zinc ion transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	29986
	214922
	ENSG00000165794
	ENSMUSG00000072572
	Q9NP94
	G3X943
	NM_014579; NM_001256588
	NM_001039676
	NP_001243517; NP_055394
	NP_001034765
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 21:44, 26 November 2023

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.^[5]^[6]^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165794 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000072572 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
^ Yamaguchi S (Jun 1995). "[Subtraction cloning of growth arrest inducible genes in normal human epithelial cells]". Kokubyo Gakkai Zasshi. 62 (1): 78–93. doi:10.5357/koubyou.62.78. PMID 7751801.
^ "Entrez Gene: SLC39A2 solute carrier family 39 (zinc transporter), member 2".

Further reading[edit]

Gong J, Xu J, Bezanilla M, et al. (1999). "Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2". Science. 285 (5433): 1565–9. doi:10.1126/science.285.5433.1565. PMID 10477520.
Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Desouki MM, Geradts J, Milon B, et al. (2007). "hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands". Mol. Cancer. 6: 37. doi:10.1186/1476-4598-6-37. PMC 1892035. PMID 17550612.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165794 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000072572 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10681536-5] Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.

[pmid7751801-6] Yamaguchi S (Jun 1995). "[Subtraction cloning of growth arrest inducible genes in normal human epithelial cells]". Kokubyo Gakkai Zasshi. 62 (1): 78–93. doi:10.5357/koubyou.62.78. PMID 7751801.

[entrez-7] "Entrez Gene: SLC39A2 solute carrier family 39 (zinc transporter), member 2".

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[2]

[3]

[4]

[5]

[6]

[7]

@@ Line 1: / Line 1: @@
+{{Short description|Protein found in humans}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Zinc transporter ZIP2''' is a [[protein]] that in humans is encoded by the ''SLC39A2'' [[gene]].<ref name="pmid10681536">{{cite journal | vauthors = Gaither LA, Eide DJ | title = Functional expression of the human hZIP2 zinc transporter | journal = J Biol Chem | volume = 275 | issue = 8 | pages = 5560–4 |date=Mar 2000 | pmid = 10681536 | doi =10.1074/jbc.275.8.5560  | doi-access = free }}</ref><ref name="pmid7751801">{{cite journal | author = Yamaguchi S | title = [Subtraction cloning of growth arrest inducible genes in normal human epithelial cells] | journal = Kokubyo Gakkai Zasshi | volume = 62 | issue = 1 | pages = 78–93 |date=Jun 1995 | doi = 10.5357/koubyou.62.78 | pmid = 7751801 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC39A2 solute carrier family 39 (zinc transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29986}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 39 (zinc transporter), member 2
- | HGNCid = 17127
- | Symbol = SLC39A2
- | AltSymbols =; MGC119190; ZIP2
- | OMIM =
- | ECnumber =
- | Homologene = 40957
- | MGIid = 2684326
- | GeneAtlas_image1 = PBB_GE_SLC39A2_220413_at_tn.png
- | Function = {{GNF_GO|id=GO:0005385 |text = zinc ion transmembrane transporter activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046873 |text = metal ion transmembrane transporter activity}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
- | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006829 |text = zinc ion transport}} {{GNF_GO|id=GO:0030001 |text = metal ion transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 29986
-    | Hs_Ensembl = ENSG00000165794
-    | Hs_RefseqProtein = NP_055394
-    | Hs_RefseqmRNA = NM_014579
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 14
-    | Hs_GenLoc_start = 20537289
-    | Hs_GenLoc_end = 20539870
-    | Hs_Uniprot = Q9NP94
-    | Mm_EntrezGene = 214922
-    | Mm_Ensembl = ENSMUSG00000072572
-    | Mm_RefseqmRNA = XM_972857
-    | Mm_RefseqProtein = XP_977951
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 14
-    | Mm_GenLoc_start = 50815610
-    | Mm_GenLoc_end = 50818696
-    | Mm_Uniprot =
-  }}
-}}
-'''Solute carrier family 39 (zinc transporter), member 2''', also known as '''SLC39A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC39A2 solute carrier family 39 (zinc transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29986| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
 ==See also==
@@ Line 62: / Line 11: @@
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal   |vauthors=Gong J, Xu J, Bezanilla M, etal |title=Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. |journal=Science |volume=285 |issue= 5433 |pages= 1565–9 |year= 1999 |pmid= 10477520 |doi=10.1126/science.285.5433.1565  }}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Croci C, Brändstatter JH, Enz R |title=ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6128–35 |year= 2003 |pmid= 12431995 |doi= 10.1074/jbc.M205162200 |doi-access= free }}
-| citations =
-*{{cite journal  | author=Yamaguchi S |title=[Subtraction cloning of growth arrest inducible genes in normal human epithelial cells] |journal=Kokubyo Gakkai Zasshi |volume=62 |issue= 1 |pages= 78-93 |year= 1995 |pmid= 7751801 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Gong J, Xu J, Bezanilla M, ''et al.'' |title=Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. |journal=Science |volume=285 |issue= 5433 |pages= 1565-9 |year= 1999 |pmid= 10477520 |doi=  }}
+*{{cite journal   |vauthors=Dufner-Beattie J, Langmade SJ, Wang F, etal |title=Structure, function, and regulation of a subfamily of mouse zinc transporter genes. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50142–50 |year= 2004 |pmid= 14525987 |doi= 10.1074/jbc.M304163200 |doi-access= free }}
-*{{cite journal  | author=Gaither LA, Eide DJ |title=Functional expression of the human hZIP2 zinc transporter. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5560-4 |year= 2000 |pmid= 10681536 |doi=  }}
+*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 }}
-*{{cite journal  | author=Croci C, Brändstatter JH, Enz R |title=ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6128-35 |year= 2003 |pmid= 12431995 |doi= 10.1074/jbc.M205162200 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal  | author=Dufner-Beattie J, Langmade SJ, Wang F, ''et al.'' |title=Structure, function, and regulation of a subfamily of mouse zinc transporter genes. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50142-50 |year= 2004 |pmid= 14525987 |doi= 10.1074/jbc.M304163200 }}
+*{{cite journal   |vauthors=Desouki MM, Geradts J, Milon B, etal |title=hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. |journal=Mol. Cancer |volume=6 |pages= 37 |year= 2007 |pmid= 17550612 |doi= 10.1186/1476-4598-6-37  | pmc=1892035 |doi-access=free }}
-*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
-*{{cite journal  | author=Desouki MM, Geradts J, Milon B, ''et al.'' |title=hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. |journal=Mol. Cancer |volume=6 |issue=  |pages= 37 |year= 2007 |pmid= 17550612 |doi= 10.1186/1476-4598-6-37 }}
-}}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
-[[Category:Transport proteins]]
-[[Category:Transmembrane proteins]]
+[[Category:Solute carrier family]]
+{{membrane-protein-stub}}

Latest revision as of 21:44, 26 November 2023

See also[edit]

References[edit]

Further reading[edit]