Anion exchange protein 2: Difference between revisions
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'''Anion exchange protein 2''' (AE2) is a [[membrane transport protein]] that in humans is encoded by the ''SLC4A2'' [[gene]].<ref name="pmid8434259">{{cite journal | author = Tanner MJ | title = Molecular and cellular biology of the erythrocyte anion exchanger (AE1) | journal = Semin Hematol | volume = 30 | issue = 1 | pages = 34–57 | year = 1993 | month = Mar | pmid = 8434259 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6522| accessdate = }}</ref> AE2 is functionally similar to the [[Band 3]] [[chloride|Cl<sup>-</sup>]]/[[bicarbonate|HCO3<sup>-</sup>]] [[Secondary active transport#Antiport|exchange]] protein. |
'''Anion exchange protein 2''' (AE2) is a [[membrane transport protein]] that in humans is encoded by the ''SLC4A2'' [[gene]].<ref name="pmid8434259">{{cite journal | author = Tanner MJ | title = Molecular and cellular biology of the erythrocyte anion exchanger (AE1) | journal = Semin Hematol | volume = 30 | issue = 1 | pages = 34–57 | year = 1993 | month = Mar | pmid = 8434259 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6522| accessdate = }}</ref> AE2 is functionally similar to the [[Band 3]] [[chloride|Cl<sup>-</sup>]]/[[bicarbonate|HCO3<sup>-</sup>]] [[Secondary active transport#Antiport|exchange]] protein. |
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[[Mice#Laboratory mice|Mice]] have been used to explore the function of AE2. AE2 contributes to [[Epithelial polarity#Basolateral membranes|basolateral membrane]] HCO3<sup>-</sup> transport in the [[gastrointestinal tract]].<ref name="pmid20110461">{{cite journal | author = Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE | title = AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon | journal = Am. J. Physiol. Gastrointest. Liver Physiol. | volume = 298 | issue = 4 | pages = G493–503 | year = 2010 | month = April | pmid = 20110461 | pmc = 2853300 | doi = 10.1152/ajpgi.00178.2009 }}</ref> AE3 is required for [[spermiogenesis]] in mice.<ref name="pmid14673081">{{cite journal | author = Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP | title = Anion exchanger 2 is essential for spermiogenesis in mice | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 26 | pages = 15847–52 | year = 2003 | month = December | pmid = 14673081 | pmc = 307656 | doi = 10.1073/pnas.2536127100 }}</ref> AE2 is required for normal [[osteoclast]] function.<ref name="pmid18971331">{{cite journal | author = Wu J, Glimcher LH, Aliprantis AO | title = HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 44 | pages = 16934–9 | year = 2008 | month = November | pmid = 18971331 | pmc = 2579356 | doi = 10.1073/pnas.0808763105 | url = }}</ref><ref name="pmid19164575">{{cite journal | author = Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O | title = Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 106 | issue = 5 | pages = 1638–41 | year = 2009 | month = February | pmid = 19164575 | pmc = 2635809 | doi = 10.1073/pnas.0811682106 }}</ref> The activity of AE2 is sensitive to [[pH]].<ref name="pmid19103596">{{cite journal | author = Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL | title = Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH | journal = J. Biol. Chem. | volume = 284 | issue = 10 | pages = 6126–39 | year = 2009 | month = March | pmid = 19103596 | pmc = 2649077 | doi = 10.1074/jbc.M802051200 }}</ref> |
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[[Mice#Laboratory mice|Mice]] have been used to explore the function of AE2. AE2 contributes to [[Epithelial polarity#Basolateral membranes|basolateral membrane]] HCO3<sup>-</sup> transport in the [[gastrointestinal tract]].<ref>{{Cite pmid|20110461}}</ref> AE3 is required for [[spermiogenesis]] in mice.<ref>{{Cite pmid|14673081}}</ref> AE2 is required for normal [[osteoclast]] function.<ref>{{Cite pmid|18971331}}</ref><ref>{{Cite pmid|19164575}}</ref> The activity of AE2 is sensitive to [[pH]].<ref>{{Cite pmid|19103596}}</ref> |
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AE3 has been suggested as a target for prevention of [[Diabetes mellitus|diabetic vasculopathy]].<ref>{{ |
AE3 has been suggested as a target for prevention of [[Diabetes mellitus|diabetic vasculopathy]].<ref name="pmid20180022">{{cite journal | author = Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M | title = Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway | journal = Apoptosis | volume = 15 | issue = 6 | pages = 693–704 | year = 2010 | month = June | pmid = 20180022 | doi = 10.1007/s10495-010-0477-9 }}</ref> |
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==See also== |
==See also== |
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==Further reading== |
==Further reading== |
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*{{cite journal | author=Gehrig H, Müller W, Appelhans H |title=Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney. |journal=Biochim. Biophys. Acta |volume=1130 |issue= 3 |pages= 326–8 |year= 1992 |pmid= 1562608 |doi= }} |
*{{cite journal | author=Gehrig H, Müller W, Appelhans H |title=Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney. |journal=Biochim. Biophys. Acta |volume=1130 |issue= 3 |pages= 326–8 |year= 1992 |pmid= 1562608 |doi= }} |
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*{{cite journal | author=Korsgren C, Cohen CM |title=Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3. |journal=J. Biol. Chem. |volume=263 |issue= 21 |pages= 10212–8 |year= 1988 |pmid= 2968981 |doi= }} |
*{{cite journal | author=Korsgren C, Cohen CM |title=Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3. |journal=J. Biol. Chem. |volume=263 |issue= 21 |pages= 10212–8 |year= 1988 |pmid= 2968981 |doi= }} |
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*{{cite journal | author=Holappa K, Suokas M, Soininen P, Kellokumpu S |title=Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts. |journal=J. Histochem. Cytochem. |volume=49 |issue= 2 |pages= 259–69 |year= 2001 |pmid= 11156694 |doi= }} |
*{{cite journal | author=Holappa K, Suokas M, Soininen P, Kellokumpu S |title=Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts. |journal=J. Histochem. Cytochem. |volume=49 |issue= 2 |pages= 259–69 |year= 2001 |pmid= 11156694 |doi= }} |
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*{{cite journal | author=Soleimani M, Greeley T, Petrovic S, ''et al.'' |title=Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex. |journal=Am. J. Physiol. Renal Physiol. |volume=280 |issue= 2 |pages= F356–64 |year= 2001 |pmid= 11208611 |doi= }} |
*{{cite journal | author=Soleimani M, Greeley T, Petrovic S, ''et al.'' |title=Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex. |journal=Am. J. Physiol. Renal Physiol. |volume=280 |issue= 2 |pages= F356–64 |year= 2001 |pmid= 11208611 |doi= }} |
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Revision as of 09:30, 25 November 2012
Template:PBB Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.[1][2] AE2 is functionally similar to the Band 3 Cl-/HCO3- exchange protein.
Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3- transport in the gastrointestinal tract.[3] AE3 is required for spermiogenesis in mice.[4] AE2 is required for normal osteoclast function.[5][6] The activity of AE2 is sensitive to pH.[7]
AE3 has been suggested as a target for prevention of diabetic vasculopathy.[8]
See also
References
- ^ Tanner MJ (1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol. 30 (1): 34–57. PMID 8434259.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".
- ^ Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (2010). "AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Wu J, Glimcher LH, Aliprantis AO (2008). "HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (2009). "Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis. 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Further reading
- Gehrig H, Müller W, Appelhans H (1992). "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney". Biochim. Biophys. Acta. 1130 (3): 326–8. PMID 1562608.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Korsgren C, Cohen CM (1988). "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3". J. Biol. Chem. 263 (21): 10212–8. PMID 2968981.
- Demuth DR, Showe LC, Ballantine M; et al. (1986). "Cloning and structural characterization of a human non-erythroid band 3-like protein". EMBO J. 5 (6): 1205–14. PMC 1166929. PMID 3015590.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Palumbo AP, Isobe M, Huebner K; et al. (1986). "Chromosomal localization of a human band 3-like gene to region 7q35----7q36". Am. J. Hum. Genet. 39 (3): 307–16. PMC 1683956. PMID 3020980.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Rybicki AC, Musto S, Schwartz RS (1995). "Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2". Biochem. J. 309. ( Pt 2): 677–81. PMC 1135783. PMID 7626035.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Havenga MJ, Bosman GJ, Appelhans H, De Grip WJ (1995). "Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0". Brain Res. Mol. Brain Res. 25 (1–2): 97–104. doi:10.1016/0169-328X(94)90283-6. PMID 7984058.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Medina JF, Acín A, Prieto J (1997). "Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene". Genomics. 39 (1): 74–85. doi:10.1006/geno.1996.4467. PMID 9027488.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - García C, Montuenga LM, Medina JF, Prieto J (1998). "In situ detection of AE2 anion-exchanger mRNA in the human liver". Cell Tissue Res. 291 (3): 481–8. doi:10.1007/s004410051017. PMID 9477304.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Jöns T, Drenckhahn D (1998). "Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells". Eur. J. Cell Biol. 75 (3): 232–6. PMID 9587054.
- Mobasheri A, Golding S, Pagakis SN; et al. (1999). "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts". Cell Biol. Int. 22 (7–8): 551–62. doi:10.1006/cbir.1998.0299. PMID 10452823.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Hyde K, Harrison D, Hollingsworth MA, Harris A (1999). "Chloride-bicarbonate exchangers in the human fetal pancreas". Biochem. Biophys. Res. Commun. 263 (2): 315–21. doi:10.1006/bbrc.1999.1367. PMID 10491290.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Holappa K, Mustonen M, Parvinen M; et al. (1999). "Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis". Biol. Reprod. 61 (4): 981–6. doi:10.1095/biolreprod61.4.981. PMID 10491633.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Karet FE, Finberg KE, Nayir A; et al. (2000). "Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34". Am. J. Hum. Genet. 65 (6): 1656–65. doi:10.1086/302679. PMC 1288376. PMID 10577919.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Medina JF, Lecanda J, Acín A; et al. (2000). "Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene". Biochem. Biophys. Res. Commun. 267 (1): 228–35. doi:10.1006/bbrc.1999.1951. PMID 10623603.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Vince JW, Reithmeier RA (2000). "Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1". Biochemistry. 39 (18): 5527–33. doi:10.1021/bi992564p. PMID 10820026.
- Holappa K, Suokas M, Soininen P, Kellokumpu S (2001). "Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts". J. Histochem. Cytochem. 49 (2): 259–69. PMID 11156694.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Soleimani M, Greeley T, Petrovic S; et al. (2001). "Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex". Am. J. Physiol. Renal Physiol. 280 (2): F356–64. PMID 11208611.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
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