Y+L amino acid transporter 2: Difference between revisions

SLC7A6
Identifiers
Aliases	SLC7A6, LAT-2, LAT3, y+LAT-2, solute carrier family 7 member 6
External IDs	OMIM: 605641; MGI: 2142598; HomoloGene: 62496; GeneCards: SLC7A6; OMA:SLC7A6 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,301,823 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,925,338 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; gastric mucosa; ; subcutaneous adipose tissue; ; tibialis anterior muscle; ; left ventricle; ; tibial nerve; ; abdominal fat; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; lymph node;
	Top expressed in
	spermatocyte; ; primitive streak; ; neural tube; ; external carotid artery; ; abdominal wall; ; internal carotid artery; ; condyle; ; blastocyst; ; fossa; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	L-amino acid transmembrane transporter activity; antiporter activity; amino acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; basolateral plasma membrane; integral component of plasma membrane; membrane; plasma membrane; intracellular membrane-bounded organelle;
Biological process	cellular amino acid metabolic process; amino acid transmembrane transport; amino acid transport; leukocyte migration; L-alpha-amino acid transmembrane transport; transmembrane transport; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	9057
	330836
	ENSG00000103064
	ENSMUSG00000031904
	Q92536
	Q8BGK6
	NM_001076785; NM_003983
	NM_178798; NM_001357381; NM_001357382
	NP_001070253; NP_003974; NP_001070253.1; NP_003974.3
	NP_848913; NP_001344310; NP_001344311
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 14:32, 11 February 2017

Solute carrier family 7 member 6 also known as cationic amino acid transporter, y+ system or Y+L amino acid transporter 2 is a protein that in humans is encoded by the SLC7A6 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103064 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031904 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".
^ Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F (January 1999). "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". The EMBO Journal. 18 (1): 49–57. doi:10.1093/emboj/18.1.49. PMC 1171101. PMID 9878049.

Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdar A, Tryggvason K, Yan K (July 2009). "Amino acid transporter LAT3 is required for podocyte development and function". Journal of the American Society of Nephrology. 20 (7): 1586–96. doi:10.1681/ASN.2008070809. PMC 2709689. PMID 19443642.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Torrents D, Estévez R, Pineda M, Fernández E, Lloberas J, Shi YB, Zorzano A, Palacín M (December 1998). "Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance". The Journal of Biological Chemistry. 273 (49): 32437–45. doi:10.1074/jbc.273.49.32437. PMID 9829974.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Bröer A, Wagner CA, Lang F, Bröer S (August 2000). "The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine". The Biochemical Journal. 349 Pt 3 (Pt 3): 787–95. PMC 1221206. PMID 10903140.
Xu D, Hemler ME (August 2005). "Metabolic activation-related CD147-CD98 complex". Molecular & Cellular Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103064 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031904 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".

[pmid9878049-6] Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F (January 1999). "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". The EMBO Journal. 18 (1): 49–57. doi:10.1093/emboj/18.1.49. PMC 1171101. PMID 9878049.

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@@ Line 1: / Line 1: @@
 {{Infobox_gene}}
-'''Solute carrier family 7 member 6''' also known as '''cationic amino acid transporter, y+ system''' or '''Y+L amino acid transporter 2''' is a [[protein]] that in humans is encoded by the ''SLC7A6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 7 (cationic amino acid transporter| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9057| accessdate = }}</ref><ref name="pmid9878049">{{cite journal |author1=Pfeiffer R |author2=Rossier G |author3=Spindler B |author4=Meier C |author5=Kühn L |author6=Verrey F | title = Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family | journal = EMBO J. | volume = 18 | issue = 1 | pages = 49–57 |date=January 1999 | pmid = 9878049 | pmc = 1171101 | doi = 10.1093/emboj/18.1.49 | url =  }}</ref>
+'''Solute carrier family 7 member 6''' also known as '''cationic amino acid transporter, y+ system''' or '''Y+L amino acid transporter 2''' is a [[protein]] that in humans is encoded by the ''SLC7A6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 7 (cationic amino acid transporter| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9057| accessdate = }}</ref><ref name="pmid9878049">{{cite journal | vauthors = Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F | title = Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family | journal = The EMBO Journal | volume = 18 | issue = 1 | pages = 49–57 | date = January 1999 | pmid = 9878049 | pmc = 1171101 | doi = 10.1093/emboj/18.1.49 }}</ref>
-==See also==
+== See also ==
 * [[Heterodimeric amino acid transporter]]
-==References==
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-* {{cite journal |author1=Sekine Y |author2=Nishibori Y |author3=Akimoto Y |author4=Kudo A |author5=Ito N |author6=Fukuhara D |author7=Kurayama R |author8=Higashihara E |author9=Babu E |author10=Kanai Y |author11=Asanuma K |author12=Nagata M |author13=Majumdar A |author14=Tryggvason K |author15=Yan K | title = Amino Acid Transporter LAT3 Is Required for Podocyte Development and Function | journal = J. Am. Soc. Nephrol. | volume = 20 | issue = 7 | pages = 1586–96 |date=July 2009 | pmid = 19443642 | pmc = 2709689 | doi = 10.1681/ASN.2008070809 | url =  }}
+* {{cite journal | vauthors = Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdar A, Tryggvason K, Yan K | title = Amino acid transporter LAT3 is required for podocyte development and function | journal = Journal of the American Society of Nephrology | volume = 20 | issue = 7 | pages = 1586–96 | date = July 2009 | pmid = 19443642 | pmc = 2709689 | doi = 10.1681/ASN.2008070809 }}
-* {{cite journal |author1=Suzuki Y |author2=Yamashita R |author3=Shirota M |author4=Sakakibara Y |author5=Chiba J |author6=Mizushima-Sugano J |author7=Nakai K |author8=Sugano S | title = Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 |date=September 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 | url =  }}
+* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = September 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
-* {{cite journal |author1=Torrents D |author2=Estévez R |author3=Pineda M |author4=Fernández E |author5=Lloberas J |author6=Shi YB |author7=Zorzano A |author8=Palacín M | title = Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance | journal = J. Biol. Chem. | volume = 273 | issue = 49 | pages = 32437–45 |date=December 1998 | pmid = 9829974 | doi = 10.1074/jbc.273.49.32437| url =  }}
+* {{cite journal | vauthors = Torrents D, Estévez R, Pineda M, Fernández E, Lloberas J, Shi YB, Zorzano A, Palacín M | title = Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance | journal = The Journal of Biological Chemistry | volume = 273 | issue = 49 | pages = 32437–45 | date = December 1998 | pmid = 9829974 | doi = 10.1074/jbc.273.49.32437 }}
-* {{cite journal |author1=Bröer A |author2=Wagner CA |author3=Lang F |author4=Bröer S | title = The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine | journal = Biochem. J. | volume = 349 Pt 3 | issue = Pt 3| pages = 787–95 |date=August 2000 | pmid = 10903140 | pmc = 1221206 | doi = | url =  }}
+* {{cite journal | vauthors = Bröer A, Wagner CA, Lang F, Bröer S | title = The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine | journal = The Biochemical Journal | volume = 349 Pt 3 | issue = Pt 3 | pages = 787–95 | date = August 2000 | pmid = 10903140 | pmc = 1221206 | doi =  }}
-* {{cite journal |author1=Xu D |author2=Hemler ME | title = Metabolic activation-related CD147-CD98 complex | journal = Mol. Cell Proteomics | volume = 4 | issue = 8 | pages = 1061–71 |date=August 2005 | pmid = 15901826 | pmc = 1351277 | doi = 10.1074/mcp.M400207-MCP200 | url =  }}
+* {{cite journal | vauthors = Xu D, Hemler ME | title = Metabolic activation-related CD147-CD98 complex | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 8 | pages = 1061–71 | date = August 2005 | pmid = 15901826 | pmc = 1351277 | doi = 10.1074/mcp.M400207-MCP200 }}
 {{refend}}
@@ Line 20: / Line 20: @@
 [[Category:Solute carrier family]]
 {{membrane-protein-stub}}